Results 1 to 10 of about 43,474 (209)

Jurkat T-cell lines exhibit marked genomic instability affecting karyotype, mutational profile, gene expression, immunophenotype and function [PDF]

Scientific Reports
The Jurkat cell line, derived from a case of T-cell lymphoblastic leukaemia, is widely employed as a model T-cell for biomedical research, including for the preclinical characterisation of cellular therapies such as chimeric antigen receptor T-cells ...
Andrew Wilson, Nathaniel Dasyam, Felix O’Hagan, Dianna Farrell, Claire Turner, Anne Jay, Alfonso Schmidt, Rachel Beddow, Tina Lillis, Tom Chin, Rachel Perret, Michelle McCulley, Robert Weinkove   +12 more
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Intercellular mechanical communication drives the directional migration of Jurkat T immune cells [PDF]

Mechanobiology in Medicine
Although the mechanisms by which chemokines regulate immune responses have been extensively elucidated, the contributions of biophysical mechanical cues to the modulation of immune cell migratory behaviors remain largely unexplored.
Hongjie Liu, Qingyu Zhang, Jia Guo, Linyan Chen, Bo Li, Mingxing Ouyang, Linhong Deng   +6 more
doaj   +2 more sources

RNA-Seq analysis of early transcriptional responses to activation in the leukaemic Jurkat E6.1 T cell line [version 2; peer review: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2021
Background: The leukaemia-derived Jurkat E6.1 cell line has been used as a model T cell in the study of many aspects of T cell biology, most notably activation in response to T cell receptor (TCR) engagement.
Suet Ling Felce, Michael L. Dustin, Gillian Farnie, James H. Felce   +3 more
doaj   +1 more source

Significance of nutrient media choice for the long-term cultures of leukemic T-lymphoblasts

Медицинская иммунология, 2021
Correct choice of nutrient media for culturing different types of cells in various applications is one of the most important aspects of modern biotechnology, since chemical composition of the culture media largely contains the necessary metabolites to ...
L. S. Litvinova, K. A. Yurova, V. V. Shchupletsova, N. D. Gazatova, O. G. Khaziakhmatova, V. V. Malashchenko, E. O. Shunkin, N. M. Todosenko, E. S. Melashchenko, M. Yu. Khlusova, I. А. Khlusov   +10 more
doaj   +1 more source

Protective effects of pentoxifylline on T-cell viability under inflammatory conditions

European Journal of Inflammation, 2022
Introduction: Pentoxifylline (PTX) reduces the levels of pro-inflammatory cytokines; however, its effects on immune system is not well understood. The aim of this study was to investigate the effect of PTX on T cells under inflammatory conditions in co ...
Sung-Joon Park, Sung-Hyuk Choi, Young-Duck Cho, Jung-Youn Kim, Han-Jin Cho, Kyung-Hwan Kim, Won-Young Kim   +6 more
doaj   +1 more source

CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis

Frontiers in Pharmacology, 2023
Introduction: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy of the lymphoid progenitor cells, contributing to ∼ 20% of the total ALL cases, with a higher prevalence in adults than children.
Muhammad Jamal, Yufei Lei, Hengjing He, Xingruo Zeng, Hina Iqbal Bangash, Di Xiao, Liang Shao, Fuling Zhou, Quiping Zhang, Quiping Zhang   +9 more
doaj   +1 more source

CD63⁺ and MHC Class I⁺ Subsets of Extracellular Vesicles Produced by Wild-Type and CD47-Deficient Jurkat T Cells Have Divergent Functional Effects on Endothelial Cell Gene Expression

Biomedicines, 2021
T cells and endothelial cells engage in bidirectional communication that regulates angiogenesis and T cell transmigration. Extracellular vesicles (EVs) mediate intercellular communication by the transfer of bioactive molecules including RNAs.
Sukhbir Kaur, Abdel G. Elkahloun, Jennifer D. Petersen, Anush Arakelyan, Ferenc Livak, Satya P. Singh, Leonid Margolis, Joshua Zimmerberg, David D. Roberts   +8 more
doaj   +1 more source

Limited T-Cell-Stimulating Effect of Cytochalasin-B-Induced Membrane Vesicles Isolated from Artificial Antigen-Presenting Cells

Vaccines, 2022
Artificial antigen-presenting cells (aAPCs) that stably express particular HLA and co-stimulatory molecules by gene transfer have been developed to effectively stimulate T cells. To investigate whether cytochalsin-B-induced membrane vesicles derived from
Yeongwon Kim, Sueon Kim, Cheol-Hwa Hong, You-Seok Hyun, In-Cheol Baek, Tai-Gyu Kim   +5 more
doaj   +1 more source

Calcium enhances polyplex-mediated transfection efficiency of plasmid DNA in Jurkat cells

Drug Delivery, 2020
Jurkat, an immortalized cell line derived from human leukemic T lymphocytes, has been employed as an excellent surrogate model of human primary T-cells for the advancement of T-cell biology and their applications in medicine.
V. S. S. Abhinav Ayyadevara, Kyung-Ho Roh   +1 more
doaj   +1 more source

A genome-wide survey of mutations in the Jurkat cell line

BMC Genomics, 2018
Background The Jurkat cell line has an extensive history as a model of T cell signaling. But at the turn of the 21st century, some expression irregularities were observed, raising doubts about how closely the cell line paralleled normal human T cells ...
Louis Gioia, Azeem Siddique, Steven R. Head, Daniel R. Salomon, Andrew I. Su   +4 more
doaj   +1 more source