Results 81 to 90 of about 1,185,148 (303)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Ukraine, ideology, and arms: Coming to terms with just war theory [PDF]
Filozofija i DruštvoThe Russian invasion of Ukraine has challenged the ideals of peace that I and many other left-wing critical intellectuals hold dear. By the end of the 18th century, Immanuel Kant argued that the realist law of peoples and the idea of just war ...
Sørensen Asger
doaj +1 more source
The Historical Contingencies of Conflict Resolution [PDF]
, 2013 This article reviews the historical contingency of theory and practice in conflict engagement. World War II and the Cold War produced adversarial, distributive, competitive, and scarce resources conceptions of negotiation and conflict resolution, as ...
Menkel-Meadow, Carrie
core +2 more sources
Die Lehre vom gerechten Krieg - obsolet oder unverzichtbar? [PDF]
, 2005 Friedensforscherinnen und -forscher, sofern sie sich überhaupt für normative Fragen interessieren, begegnen der Lehre vom gerechten Krieg gewöhnlich mit Ablehnung.
Mayer, Peter
core +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Peacekeeping & Jus Post Bellum: Towards a Concept of Rules in Post-Conflict Situations [PDF]
Central European Journal of International & Security Studies, 2011 This article argues that post-conflict peacekeeping should be seen as highly valuable for further developing jus post bellum, since the UN is the main actor in contemporary post-conflict situations.
Ivar Scheers
doaj
Prefaces and Postscripts: Walzer’s \u3cem\u3eJust and Unjust Wars\u3c/em\u3e at Age 40 [PDF]
, 2017 This paper was written as a keynote address for a conference on Michael Walzer’s Just and Unjust War on the 40th anniversary of its publication. It discusses the significance of the book, and examines the updating prefaces Walzer wrote to the five ...
Luban, David
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source