Results 1 to 10 of about 54,427 (263)

Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE)

Molecular and Cellular Pediatrics, 2023
Systemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Approximately 15–20% of SLE patients develop the disease during childhood or adolescence (juvenile-onset SLE/jSLE).
Valentina Natoli, Amandine Charras, Gabriele Hahn, Christian M. Hedrich   +3 more
doaj   +4 more sources

Cutaneous manifestations of juvenile onset lupus erythematosus: A clinical study

Indian Journal of Paediatric Dermatology, 2018
Introduction: Juvenile-onset systemic lupus erythematosus (SLE) is one of the most common systemic autoimmune connective tissue disorders in children.
Vinitha Panicker, Anil Mathew, Gopikrishnan Anjaneyan, Soumya Jagadeesan, S. Lekshmi, Jacob Thomas   +5 more
doaj   +3 more sources

OA21 Juvenile onset systemic lupus erythematosus: a pair of siblings [PDF]

Rheumatol Adv Pract
We present the cases of two siblings both of whom were born in Goa to non-consanguineous parents with juvenile onset systemic lupus erythematosus (jSLE) with differing clinical and laboratory features. Patient 1: Presented acutely in 2022 at
Rosemary Waller, Inga Turtsevich
europepmc   +3 more sources

cAMP Response Element Modulator α Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus. [PDF]

J Immunol, 2019
Key Points CREMα induces DUSP4 phosphatase expression in CD4+ T cells. DUSP4 promotes IL-17A and reduces IL-2 production by effector T cells. The CREMα/DUSP4 axis is involved in the pathophysiology of SLE.
Hofmann SR, Mäbert K, Kapplusch F, Russ S, Northey S, Beresford MW, Tsokos GC, Hedrich CM.   +7 more
europepmc   +2 more sources

Effectiveness of Belimumab for Glucocorticoid Discontinuation in Juvenile-Onset Lupus Nephritis. [PDF]

Indian J Nephrol
Lupus nephritis (LN) is an important complication of systemic lupus erythematosus, for which glucocorticoids (GCs) are the primary treatment. Due to the side effects associated with GCs, their long-term use should ideally be tapered and discontinued.
Kise T, Uehara M.
europepmc   +2 more sources

Case Report: Novel UNC93B1 variant causes rheumatoid arthritis and interstitial pneumonia [PDF]

Frontiers in Immunology
BackgroundUNC93B1 is a transmembrane protein essential for regulating toll-like receptors (TLRs). Pathogenic variants in human UNC93B1 have recently been described in a limited number of patients with childhood systemic lupus erythematosus and chilblain ...
Tingyan He, Junbin Ou, Lijuan Huang, Xinyi Zhou, Linlin Wang, Xiaolin Li, Jun Yang   +6 more
doaj   +2 more sources

Juvenile-onset Systemic Lupus Erythematosus: Recent Advances in Pathogenesis and Treatment. [PDF]

Curr Rheumatol Rep
This review summarizes recent advances in understanding the pathogenesis and therapeutic landscape of juvenile-onset systemic lupus erythematosus (jSLE), with a focus on how emerging genetic and immunologic insights inform patient stratification ...
Natoli V, Charras A, Smith EM, Hedrich CM.   +3 more
europepmc   +2 more sources

CAR-T cell therapy for juvenile-onset autoimmune diseases: a promising future? [PDF]

Arthritis Research & Therapy
Chimeric antigen receptor (CAR) T-cell therapy targeting B cells has shown promising results, including drug-free remission, in adult-onset autoimmune diseases.
Maurine Jouret, Sebastien Viel, Benjamin Fournier, Sarah Benezech, Jérome Avouac, Marc Scherlinger, Alexandre Belot, for the C3I consortium   +7 more
doaj   +2 more sources

Severe Juvenile-Onset Systemic Lupus Erythematosus: A Case Series-Based Review and Update

Children, 2023
Juvenile-onset systemic lupus erythematosus (jSLE) is a multisystemic disease diagnosed in young patients based on the clinical criteria of the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR).
Sergi Huerta-Calpe, Ignacio Del Castillo-Velilla, Aida Felipe-Villalobos, Iolanda Jordan, Lluïsa Hernández-Platero   +4 more
doaj   +2 more sources

Across ancestries, HLA-B∗08:01∼DRB1∗03:01 (DR3) and HLA-DQA∗01:02 (DR2) increase the risk to develop juvenile-onset systemic lupus erythematosus through low complement C4 levels

Journal of Translational Autoimmunity
Objective: Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease with a strong genetic component. Genetic burden is higher in children when compared to patients with adult-onset SLE, contributing to earlier disease expression ...
Yves Renaudineau, Amandine Charras, Valentina Natoli, Nicolas Congy-Jolivet, Sam Haldenby, Xuan Liu, Yongxiang Fang, Eve MD. Smith, Michael W. Beresford, Christian M. Hedrich, Carla Roberts, Eslam Al-Abadi, Kate Armon, Kathryn Bailey, Coziana Ciurtin, Janet Gardner-Medwin, Kirsty Haslam, Daniel P. Hawley, Alice Leahy, Valentina Leone, Flora McErlane, Gita Modgil, Clarissa Pilkington, Athimalaipet V. Ramanan, Satyapal Rangaraj, Phil Riley, Arani Sridhar   +26 more
doaj   +2 more sources