Background: The diagnosis of systemic lupus erythematosus (SLE) in children is challenging. The heterogeneous manifestations and disease impact on the child’s growth highlight the importance of timely diagnosis and management.
Rasha E. Gheith +5 more
doaj +1 more source
Background. Neuropsychiatric lupus (NPSLE) serves as a marker of severe disease in children with juvenile onset systemic lupus erythematosus (JSLE). This study aims to characterise the clinical and imaging features at diagnosis; and outcomes after
Sern Chin Lim +4 more
doaj +1 more source
An Unprecedented Triad: Simultaneous Acute Pancreatitis, Axonal Polyneuropathy, and Type 1 Diabetes Mellitus in a Catastrophic Juvenile Lupus Flare [PDF]
ABSTRACT A 14‐year‐old female with juvenile systemic lupus erythematosus (jSLE) presented with a life‐threatening and previously unreported triad: the simultaneous onset of acute pancreatitis, severe axonal polyneuropathy, and autoimmune Type 1 Diabetes (T1D).
Hashmi L +11 more
europepmc +2 more sources
Glyco-biomarkers: Potential determinants of cellular physiology and pathology [PDF]
Once dismissed as just the icing on the cake, sugar molecules are emerging as vital components in life’s intricate machinery. Our understanding of their function within the context of the proteins and lipids to which they are attached has matured rapidly,
Alavi, A, Axford, JS
core +2 more sources
Inadequate dietary intake of children and adolescents with juvenile idiopathic arthritis and systemic lupus erythematosus [PDF]
OBJECTIVES: To evaluate the dietary intake of children and adolescents with juvenile idiopathic arthritis (JIA) and juvenile systemic lupus erythematosus (JSLE) using a 24-hour diet recall and relating it to the patients clinical and anthropometric ...
Caetano, Michelle Caetano +6 more
core +3 more sources
Bone mineral density in juvenile onset Systemic lupus erythematosus
To compare bone mineral density in patients with juvenile-onset Systemic lupus erythematosus and healthy controls.Serial bone mineral density measurements in 27 patients with juvenile-onset systemic lupus were compared to 97 healthy age-matched controls.All patients with juvenile-onset had low bone mineral density scores at initial assessment that ...
R, Abdwani +4 more
openaire +2 more sources
Tocilizumab, an anti-interleukin-6 (IL-6) agent, is indicated as a treatment for several autoimmune or inflammatory diseases, including rheumatoid arthritis and juvenile idiopathic arthritis (JIA). IL-6 plays roles in both immune system dysregulation and
Ju-Yang Jung +3 more
doaj +1 more source
The role of apoptosis proteins and complement components in the etiopathogenesis of systemic lupus erythematosus [PDF]
Systemic lupus erythematosus is a prototypical autoimmune disease characterized by the deregulation of T and B cells, tissue infiltration by mononuclear cells, tissue damage and the production of autoantibodies.
KISS, Maria Helena Bittencourt +1 more
core +5 more sources
A discrete cluster of urinary biomarkers discriminates between active systemic lupus erythematosus patients with and without glomerulonephritis. [PDF]
BackgroundManagement of lupus nephritis (LN) would be greatly aided by the discovery of biomarkers that accurately reflect changes in disease activity.
Avila-Casado, Carmen +10 more
core +3 more sources
Rhupus arthropathy as the presenting manifestation in Juvenile SLE: a case report [PDF]
An 8.5-year-old girl was referred with swelling of both knees lasting for two years. ANA was found as negative. She was diagnosed as oligoarticular JIA. After two years of follow-up, thrombocytopenia was detected during routine screening.
Ayse Arlı, Erbil Unsal, Hakkı Akman
core +3 more sources

