Results 91 to 100 of about 18,031 (200)

Unmet Needs in the Pathogenesis and Treatment of Systemic Lupus Erythematosus [PDF]

, 2017
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease with a prevalence of approximately 1 in 1000. Over the last 30 years, advances in treatment such as use of corticosteroids and immunosuppressants have improved life expectancy and ...
Bakshi, J, Rahman, A, Segura, BT, Wincup, C   +3 more
core   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, Volume 13, Issue 8, 9 February 2026.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Quality of life in patients with juvenile-onset systemic lupus erythematosus

Journal of V. N. Karazin Kharkiv National University: Series Medicine
Background. Childhood-onset systemic lupus erythematosus (cSLE) is a rare, multisystem, and potentially life-threatening autoimmune disease with significant comorbidities and the development of a chronic, debilitating condition for the patient.
L.F. Bohmat, N.S. Shevchenko, I.M. Bessonova, T.O. Holovko   +3 more
doaj   +1 more source

Geographical Clustering of Juvenile Onset Systemic Lupus Erythematosus within the Sultanate of Oman

Oman Medical Journal, 2013
Objective: While SLE is found worldwide, there is diversity in clinical presentation of the disease according to geographical variations. The aim of this study is to describe geographical distributions of childhood onset SLE within Oman to identify ...
Ibrahim Al-Zakwani, Sharef Waadallah Sharef, Safiya Al-Abrawi, Reem Abdwani   +3 more
doaj   +1 more source

Clinical Features, Management, and Outcomes of Neuropsychiatric Lupus in Saudi Children, a Multicentric Study

Annals of Rheumatology and Autoimmunity
Introduction: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder that affects several systems, including the neurological system. At some time over the course of their illness, around one-third of all children with SLE will exhibit ...
Mohammed Nashawi, Rahaf Shigdar, Hashim Shigdar, Reima Bakry, Abdulaziz Almutairi, Faris Althubaiti, Lujain Akbar, Emtenan Basahl   +7 more
doaj   +1 more source

Mucocutaneous manifestations in juvenile-onset systemic lupus erythematosus: a review of literature. [PDF]

Pediatr Rheumatol Online J, 2015
Patients diagnosed with juvenile-onset systemic lupus erythematosus (JSLE) often have skin and oral lesions as part of their presentation. These mucocutaneous lesions, as defined by the American College of Rheumatology (ACR) in 1997, include malar rash, discoid rash, photosensitivity and oral ulcers. It is therefore essential to recognize mucocutaneous
Chiewchengchol D, Murphy R, Edwards SW, Beresford MW.   +3 more
europepmc   +4 more sources

“You can't do this, you've arthritis":Exploring the experiences of education and employment of young people with arthritis [PDF]

, 2018
Introduction: Vocational development is an integral component of adolescence with several key educational transitions occurring during this stage of life.
Farre, Albert, McDonagh, Janet E., McNiven, Abigail, Ryan, Sara, Ziebland, Sue   +4 more
core   +2 more sources

IKAROS Associated Immunodeficiency and Thrombotic Thrombocytopenic Purpura

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Pathogenic variants in IKZF1 (IKAROS) are linked to immunodeficiency, malignancy, and immune dysregulation. We describe a family with a rare IKZF1 variant presenting with humoral immunodeficiency and thrombotic thrombocytopenic purpura (TTP). A non‐consanguineous family was clinically monitored; clinical, immunological, and genetic data (exome
Ilia Spivak, Daniella Magen, Karin Weiss, Tamar Paperna, Suhair Hanna, Amos Etzioni, Adi Miller‐Barmak, Yonatan Butbul Aviel   +7 more
wiley   +1 more source

The diagnosis and management of the haematologic manifestations of lupus [PDF]

, 2016
Haematological manifestations in systemic lupus erythematosus (SLE) are frequently observed. They are diverse and range from mild to severe.
Castro, SG, Isenberg, DA, Velo-García, A   +2 more
core   +1 more source