Results 41 to 50 of about 18,031 (200)
Современная ревматология, 2022 Systemic lupus erythematosus (SLE) with juvenile onset (jSLE) is a complex autoimmune disease involving many organs and systems. The single nucleotide polymorphism rs7574865 of the STAT4 (signal switch and transcription activator 4) gene is associated ...
M. Yu. Krylov +4 more
doaj +1 more source
Early-Onset Autoimmune Disease as a Manifestation of Primary Immunodeficiency [PDF]
, 2015 Autoimmune disorders (AID) have been increasingly observed in association with primary immunodeficiencies (PIDs). Here, we discuss the interface between PID and AID, focusing on autoimmune manifestations early in life, which can be diagnostic clues for ...
Carneiro-Sampaio, Magda +1 more
core +2 more sources
Indian Journal of Rheumatology, 2021 Background: Disease activity in systemic lupus erythematosus (SLE) is associated with organ damage, outcome worsening, comorbidities, and mortalities in the patients.
Zahrah Hikmah +2 more
doaj +1 more source
Use of single photon emission computed tomography and magnetic resonance to evaluate central nervous system involvement in patients with juvenile systemic lupus erythematosus [PDF]
, 2002 The objective of the present study was to identify the single photon emission computed tomography (SPECT) and magnetic resonance (MR) findings in juvenile systemic lupus erythematosus (JSLE) patients with CNS involvement and to try to correlate them with
Alonso, Gilberto +7 more
core +2 more sources
The role of neutrophil apoptosis in juvenile‐onset systemic lupus erythematosus [PDF]
Arthritis & Rheumatism, 2009 AbstractObjectiveAccumulation of apoptotic cells may lead to the development of systemic lupus erythematosus (SLE) through a breakdown in immune tolerance. Altered neutrophil apoptosis may contribute to nuclear autoantigen exposure, ultimately leading to autoantibody generation.
Angela, Midgley +4 more
openaire +2 more sources
Revista Brasileira de Reumatologia, 2016 Objective To determine whether there is an association between the profile of cognitive dysfunction and academic outcomes in patients with juvenile systemic lupus erythematosus (JSLE).
Renan Bazuco Frittoli +5 more
doaj +1 more source
International validation of a urinary biomarker panel for identification of active lupus nephritis in children. [PDF]
, 2016 Conventional markers of juvenile-onset systemic lupus erythematosus (JSLE) disease activity fail to adequately identify lupus nephritis (LN). While individual novel urine biomarkers are good at detecting LN flares, biomarker panels may improve diagnostic
Beresford, MW +15 more
core +2 more sources
Pediatric Rheumatology Online Journal, 2018 Tocilizumab, an anti-interleukin-6 (IL-6) agent, is indicated as a treatment for several autoimmune or inflammatory diseases, including rheumatoid arthritis and juvenile idiopathic arthritis (JIA). IL-6 plays roles in both immune system dysregulation and
Ju-Yang Jung +3 more
doaj +1 more source
The presence of high mobility group box-1 and soluble receptor for advanced glycation end-products in juvenile idiopathic arthritis and juvenile systemic lupus erythematosus [PDF]
, 2014 BACKGROUND: The involvement of high mobility group box-1 (HMGB1) in various inflammatory and autoimmune diseases has been documented but clinical trials on the contribution of this pro-inflammatory alarmin in children with juvenile idiopathic ...
Bobek, Dubravka +4 more
core +1 more source
Study of early atherosclerosis in juvenile-onset systemic lupus erythematosus patients
Egyptian Rheumatology and Rehabilitation, 2017 Objective The aim of this study was to investigate early atherosclerotic changes in juvenile-onset systemic lupus erythematosus (jSLE) patients and its relation with disease activity.
Emtethal A Said Ahmed +4 more
doaj +1 more source