Results 61 to 70 of about 346,856 (231)

Erythematous scaling lesions of the face, dorsal fingers, elbows, and knees together with symmetrical muscle weakness in a child

Clinical Case Reports, 2019
Juvenile dermatomyositis shows characteristic skin lesions. However, this does not rule out co‐occurring other autoimmune diseases, which may be more prominent regarding skin manifestations.
Aleksander Markovic, Volker Schuster, Jan‐Christoph Simon, Manfred Kunz   +3 more
doaj   +1 more source

Current evidence for janus kinase inhibitors in adult and juvenile dermatomyositis and key comparisons. [PDF]

Expert Opin Pharmacother
Introduction Adult dermatomyositis (DM) and juvenile dermatomyositis (JDM) are rare autoimmune diseases with characteristic skin rashes, weakness, and other systemic features. Upregulated interferon signaling has been consistently described in both adult
Wallwork RS, Paik JJ, Kim H.
europepmc   +2 more sources

Plasma exosomes from children with juvenile dermatomyositis are taken up by human aortic endothelial cells and are associated with altered gene expression in those cells [PDF]

, 2019
BACKGROUND: The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and under-investigated. We have hypothesized that plasma exosomes,
Chen, Yanmin, Holmes, Lucy, Hu, Zihua, Jarvis, James N., Jiang, Kaiyu, Karasawa, Rie, O’Neil, Kathleen M.   +6 more
core   +1 more source

Juvenile amyopathic dermatomyositis

Dermatology Online Journal, 2005
A 3-year-old girl presented with a 6-month history of multiple, light-pink, flat-topped papules over the dorsal aspects of the metacarpophalangeal and interphalangeal joints of the hands and feet. Nailfold telangiectases, ragged cuticles, and a heliotrope color of the upper eyelids were also evident, but there was no clinical evidence of muscle ...
Henning, J Scott, Witkiewicz, Agnieszka, Schaffer, Julie V, Orlow, Seth J   +3 more
openaire   +4 more sources

Respiratory symptoms as initial manifestations of interstitial lung disease in clinically amyopathic juvenile dermatomyositis: a case report with literature review

BMC Pediatrics, 2021
Background Clinically amyopathic juvenile dermatomyositis (CAJDM) is a clinical subgroup of juvenile dermatomyositis (JDM), characterized by JDM rashes with little or no clinically evident muscle weakness.
Jingyi Xia, Gaoli Jiang, Tingting Jin, Quanli Shen, Yangyang Ma, Libo Wang, Liling Qian   +6 more
doaj   +1 more source

Assessment of the trophological status of children with rheumatic diseases

Zdorovʹe Rebenka, 2021
Background. Analyzing modern medical literature, it can be noted that in pediatric rheumatology, insufficient attention is paid to assessing the trophological status of sick children.
L.I. Omelchenko, O.M. Mukvich, E.A. Belskaya, I.V. Dudka, T.A. Ludvik   +4 more
doaj   +1 more source

A recipe for myositis : nuclear factor κB and nuclear factor of activated T-cells transcription factor pathways spiced up by cytokines [PDF]

, 2017
Nuclear factor κB (NF-κB) is a well-known pro-inflammatory transcription factor that regulates the expression of the tissue’s immune-active components, which include cytokines, chemokines and adhesion molecules.
De Paepe, Boel
core   +3 more sources

Juvenile Dermatomyositis: Updates in Pathogenesis and Biomarkers, Current Treatment, and Emerging Targeted Therapies

Pediatric Drugs
Juvenile dermatomyositis is a rare systemic inflammatory autoimmune disease involving muscle, skin, and vessels. Most patients do not fully respond to initial therapy, instead having a chronic refractory or polycyclic disease course.
Hanna Kim
semanticscholar   +1 more source

Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection

Journal of Clinical Immunology, 2021
Dear Editor, SARS-CoV-2 infection drives a marked inflammation and has been described to precede the appearance in rare occasion of various autoimmune and inflammatory diseases including clinical, radiological, muscle biopsy, and serological features ...
M. Rodero, S. Pelleau, A. Welfringer-Morin, D. Duffy, I. Melki, B. Bader-Meunier, V. Bondet, C. Gitiaux, J. Bonigen, Antoine Fayand, Laurence Courdavault Vagh Weinmann, E. Mahé, J. Charuel, M. Alyanakian, J. Herbeuval, M. White   +15 more
semanticscholar   +1 more source

Comparison between treatment naive juvenile and adult dermatomyositis muscle biopsies: difference of inflammatory cells phenotyping

Advances in Rheumatology, 2018
Background Different inflammatory cells (i.e., CD4, CD8, CD20 and CD68) are involved in pathogenesis of DM muscle. In this context, the aim of this study was to assess and compare these inflammatory cell phenotyping in muscle samples of treatment naive ...
Samuel Katsuyuki Shinjo, Adriana Maluf Elias Sallum, Sueli Mieko Oba-Shinjo, Marilda Guimarães Silva, Clovis Artur Silva, Suely Kazue Nagahashi Marie   +5 more
doaj   +1 more source