Results 51 to 60 of about 83,768 (184)

“Ectopic” theta oscillations and interictal activity during slow-wave state in the R6/1 mouse model of Huntington's disease

Neurobiology of Disease, 2012
The pathophysiology of Huntington's disease (HD) is primarily associated with striatal degeneration and a number of behavioral symptoms such as involuntary movements, cognitive decline, psychiatric disorders, and in the most juvenile-onset cases with ...
Michele Pignatelli, Fanny Lebreton, Yoon H. Cho, Xavier Leinekugel   +3 more
doaj   +1 more source

Nutritional management of individuals with Huntington’s disease: nutritional guidelines [PDF]

, 2012
The delivery of good nutritional care is a fundamental element of the management of individuals with Huntington’s disease and all patients with Huntington’s disease will, at some time, need dietary intervention because of the sequela of the disease; yet ...
Brotherton, Ailsa M, Campos, Lillian, Rae, Daniela, Rowell, Arleen, Simpson, Sheila A, Zoia, Vanessa   +5 more
core   +1 more source

Clinical trial perspective for adult and juvenile Huntington's disease using genetically-engineered mesenchymal stem cells

Neural Regeneration Research, 2016
Progress to date from our group and others indicate that using genetically-engineered mesenchymal stem cells (MSC) to secrete brain-derived neurotrophic factor (BDNF) supports our plan to submit an Investigational New Drug application to the Food and ...
P. Deng, A. Torrest, K. Pollock, H. Dahlenburg, G. Annett, J. Nolta, K. Fink   +6 more
semanticscholar   +1 more source

STIM2 Mediates Excessive Store-Operated Calcium Entry in Patient-Specific iPSC-Derived Neurons Modeling a Juvenile Form of Huntington's Disease

Frontiers in Cell and Developmental Biology, 2021
Huntington's disease (HD) is a severe autosomal-dominant neurodegenerative disorder caused by a mutation within a gene, encoding huntingtin protein. Here we have used the induced pluripotent stem cell technology to produce patient-specific terminally ...
Vladimir A. Vigont, Dmitriy A. Grekhnev, Olga S. Lebedeva, Olga S. Lebedeva, Konstantin O. Gusev, Egor A. Volovikov, Anton Yu. Skopin, Alexandra N. Bogomazova, Alexandra N. Bogomazova, Lilia D. Shuvalova, Olga A. Zubkova, Ekaterina A. Khomyakova, Lyubov N. Glushankova, Sergey A. Klyushnikov, Sergey N. Illarioshkin, Maria A. Lagarkova, Maria A. Lagarkova, Elena V. Kaznacheyeva   +17 more
doaj   +1 more source

Identification of neurodevelopmental organization of the cell populations of juvenile Huntington’s disease using dorso-ventral HD organoids and HD mouse embryos

bioRxiv
Huntington’s disease (HD) is a polyglutamine neurodegenerative disease involving pathogenesis within the striatum and cerebral cortex and a neurodevelopmental component, particularly in juvenile HD form (JOHD).
Karolina Świtońska-Kurkowska, Jakub Kubiś, Joanna Delimata-Raczek, Bart Krist, Magdalena Surdyka, Żaneta Kalinowska-Pośka, Piotr Piasecki, Luiza Handschuh, Jan Podkowinski, Magdalena Rakoczy, Anna Samelak-Czajka, Michael Hayden, Nicholas S Caron, Maciej Figiel   +13 more
semanticscholar   +1 more source

A survey-based study identifies common but unrecognized symptoms in a large series of juvenile Huntington's disease.

Neurodegenerative Disease Management, 2017
AIM The symptoms of Huntington's disease are well known, yet the symptoms of juvenile Huntington's disease (JHD) are less established due to its rarity.
A. Moser, E. Epping, P. Espe-Pfeifer, Erin Martin, L. Zhorne, K. Mathews, M. Nance, Denise Hudgell, O. Quarrell, P. Nopoulos   +9 more
semanticscholar   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Generation of the induced pluripotent stem cell line CSSi006-A (3681) from a patient affected by advanced-stage Juvenile Onset Huntington's Disease

Stem Cell Research, 2018
Juvenile Onset Huntington's Disease (JOHD) is a rare variant of HD withage of onset ≤20 years, accounting for 3–10% of all HD patients. The rarity occurrence of JOHD cases, who severely progress towards mental and physical disability with atypical ...
Giovannina Rotundo, Eris Bidollari, Daniela Ferrari, Iolanda Spasari, Laura Bernardini, Federica Consoli, Alessandro De Luca, Iolanda Santimone, Giuseppe Lamorte, Simone Migliore, Ferdinando Squitieri, Angelo Luigi Vescovi, Jessica Rosati   +12 more
doaj   +1 more source

Radiotherapy Side Effects: Comprehensive Proteomic Study Unraveled Neural Stem Cell Degenerative Differentiation upon Ionizing Radiation

Biomolecules, 2022
Cranial radiation therapy is one of the most effective treatments for childhood brain cancers. Despite the ameliorated survival rate of juvenile patients, radiation exposure-induced brain neurogenic region injury could markedly impair patients’ cognitive
Dong Liang, Meng Ning, Hang Xie, Xiaoyan He, Peigen Ren, Xiaohua Lei, Xuepei Zhang   +6 more
doaj   +1 more source

Psychogenic non-epileptic seizures in early Huntington's disease [PDF]

, 2016
Huntington's disease (HD) is a neurodegenerative condition characterised by motor dysfunction with involuntary movements and loss of voluntary control, cognitive deterioration and psychiatric problems.
Rodrigues, FB, Wild, EJ
core   +1 more source