Results 91 to 100 of about 41,602 (189)
Tidsskrift for ProfessionsstudierTo become the principal of a high school has traditionally been something highly honorable. An appointment filled with pride, significance, and, like so much else in high school, professionalism.
Lars Frode Frederiksen +1 more
doaj
Ecology, Volume 107, Issue 2, February 2026.Abstract Ocean warming is driving species range extensions into cooler regions. The direct physiological influence of warming on species performance can accelerate such extensions into novel ecosystems; however, indirect effects of invader–resident interactions in cooler regions may counter these positive effects.
Angus Mitchell +7 more
wiley +1 more source
Adoption of artificial intelligence in healthcare: A strategic transformation framework
Hong Kong Journal of Emergency Medicine, Volume 33, Issue 1, February 2026.Abstract Background Artificial intelligence (AI) holds significant promise for transforming healthcare delivery, yet many AI initiatives fail to progress beyond pilot stages or achieve sustained system‐wide impact. These failures are rarely due to technical limitations alone, but instead reflect deeper challenges related to organisational readiness ...
Mattias Wei Ren Kon +2 more
wiley +1 more source
Наука. Инновации. ТехнологииThe article analyzes the efficiency of E-KON system in the design and development process of the Shurtan gas condensate field. The study is conducted within the framework of the strategic program Digital Uzbekistan-2030 and aims to demonstrate the ...
B. Kh. Bekov, O. A. Khujaev
doaj +1 more source
A Tutorial on the Development of a Physiologically Inspired PKRO Model for Monoclonal Antibodies
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.ABSTRACT Modeling and simulations are indispensable tools to describe pharmacokinetics (PK) and pharmacodynamics to support monoclonal antibody (mAb) development. The linear PK of mAbs is commonly described by a 2‐compartment PK model, while the nonlinear PK often observed at low doses is described by target mediated drug disposition (TMDD) models ...
Georgi I. Kapitanov +5 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.ABSTRACT Cachexia is a metabolic condition that accelerates the clearance of monoclonal antibodies in cancer patients and is a known mechanism causing time‐dependent clearance. Successful anticancer treatment often ameliorates symptoms of cachexia, reducing the drug clearance over time especially in patients who respond. Serum albumin level is a common
Jeffrey R. Proctor, Harvey Wong
wiley +1 more source
Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.Pharmacophore‐based virtual screening and molecular dynamics identified pentagalloylglucose and tannic acid as potent, non‐toxic neprilysin inhibitors. These natural compounds demonstrated strong binding affinity and stable interactions with the catalytic Zn2+ site, offering promising leads for cardiovascular drug development. ABSTRACT Neprilysin (NEP),
Chung‐Ting Kuo +4 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 3, Page 709-728, February 2026.CLEC18A is a previously poorly characterized C‐type lectin. We mapped the expression of CLEC18A to the proximal tubule of the kidney and found CLEC18A to interact with sulfated glycosaminoglycans on proteoglycans. Furthermore, we found that CLEC18A plays an important role in hindering the progression of clear cell renal cell carcinomas in humans and in
Gustav Jonsson +10 more
wiley +1 more source