Results 11 to 20 of about 40 (38)

Systematic Review on the Role of Microfluidic Platforms in Advancing Scalable and Precise Microbial Bioprocessing

Engineering in Life Sciences
Microbial bioprocessing is a key technology for the production of a wide range of biomolecules, including proteins, enzymes, antibiotics, and other bioactive compounds.
Alperen Alpural, Ilgin Kimiz‐Gebologlu, Mayur Parekh, Esra Imamoglu, Zulfiqur Ali, Ozlem Yesil‐Celiktas   +5 more
doaj   +2 more sources

Can Metagenomic Analyses Be Used Effectively in Safe Food Production? [PDF]

Food Sci Nutr
This graphical abstract illustrates the metagenomic workflow applied in food safety. It outlines the process from microbial detection in food matrices to genome‐level identification via next‐generation sequencing (NGS). The visualization emphasizes the integration of modern sequencing technologies to assess foodborne pathogens and microbial communities
Delikanli-Kiyak B, Yilmaz I, Guldas M.
europepmc   +2 more sources

Exosome Secretion Drives Chemo‐Resistance of Temozolomide in Glioblastoma

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
ABSTRACT Temozolomide (TMZ) is a first‐line chemotherapeutic agent for the treatment of glioblastoma (GBM), while a majority of patients do not effectively respond to TMZ owing to the multiple resistance mechanisms. In this study, we found that TMZ treatment substantially increased the exosome secretion from GBM cell line.
Wenpei Li, Shaoping Jiang, Kun Liu, Zhi Li, Jun Yang, Weimin Liu, Yuanyu Huang, Minghui Yang, Shuai Guo, Shaobo Ruan   +9 more
wiley   +1 more source

Exosomal Oleic Acid Promotes Lymphangiogenesis and Nodal Metastasis in Cervical Cancer via the AKT/mTOR Pathway

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Cervical cancer exosomes deliver SCD‐dependent oleic acid to LECs, activating AKT/mTOR to drive VEGF‐independent lymphangiogenesis and nodal metastasis, identifying exosomal OA as a therapeutic target. ABSTRACT Cervical cancer (CC) exhibits a pronounced tropism for regional lymphatic dissemination, a process driven by tumor‐associated lymphangiogenesis.
Jinqiu Li, Xiaojing Huang, Guzhalinuer Abulizi, Ayshamgul Hasim   +3 more
wiley   +1 more source

RVG‐Modified BMSCs‐Derived Small Extracellular Vesicles Loaded With miR‐21 Alleviate Neuronal Injury Resulted From Excessive Autophagy via Targeting PTEN/Akt/mTOR Pathway After Cerebral Ischaemia

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
Bioengineered brain targeting RVG‐modified BMSCs‐derived small extracellular vesicles loaded with miR‐21 alleviate excessive autophagic neuronal injury after cerebral ischaemia via PTEN/Akt/mTOR pathway. ABSTRACT Ischaemic stroke (IS) leads to tragic disability and high adult mortality, while there are limited therapeutic measures for it.
Yiyang Li, Jiacheng Hu, Jinfen Chen, Manfei Zhou, Mingchun Liao, Yayue Yang, Jiahao Zhou, Yan Han, Bin Wang, Yonghua Zhao   +9 more
wiley   +1 more source

From Mesenchymal Stromal Cells to Extracellular Vesicles: Scalable Strategies for Ovarian Stroma Regeneration

Molecular Reproduction and Development, Volume 93, Issue 5, May 2026.
ABSTRACT Ovarian aging is characterized by the reduction of the follicular pool and a progressive loss in oocyte quality. Although these changes have initially been attributed to oocyte alterations, increasing evidence indicates that stromal deterioration plays a central role in this process.
Stefhani Martins Barcelos, Amandda Évelin Silva‐Carvalho, Felipe Perecin, Juliana Lott Carvalho   +3 more
wiley   +1 more source

Hydrogel Embedding of Mesenchymal Stem Cells Supports Extracellular Vesicle Production

Biotechnology and Bioengineering, Volume 123, Issue 4, Page 939-949, April 2026.
This study investigates the effects of 3D culture conditions on extracellular vesicle (EV) production by mesenchymal stem cells (MSCs) in a gelatin‐based hydrogel matrix (GelMA). The EVs from both conditions were found to have similar morphological, molecular, and functional properties, but 3D cultures produced more total EVs per volume.
Rachel K. Moen, Gabriella Faircloth, Nicole T. Marguerite, Mariachiara Conti, Ethan S. Lippmann, Jamey D. Young   +5 more
wiley   +1 more source

NK‐Cell‐Derived Extracellular Vesicles Engineered to Carry Senolytics Eliminate Chemotherapy‐Induced Senescent Osteosarcoma Cells

Journal of Extracellular Vesicles, Volume 14, Issue 7, July 2025.
ABSTRACT Osteosarcoma (OS) is a type of bone tumour characterized by high risk of metastatic progression and recurrence after therapy. Traditional tumour treatment methods such as radiotherapy and chemotherapy can lead to the accumulation of senescent cells in tumours.
Xianlin Yue, Jie Cui, Shifeng Ren, Yajun Zhang, Ying Li, Hongjuan Cui, Johnny Huard, Paul D. Robbins, Xiaodong Mu   +8 more
wiley   +1 more source

Engineered Extracellular Vesicles in Arthritic Diseases: Therapeutic Applications & Challenges

WIREs Nanomedicine and Nanobiotechnology, Volume 17, Issue 4, July/August 2025.
The current approach to utilize engineered EVs derived from different sources for treating OA knee joints shows their therapeutic effect after treatment. This figure was created with BioRender.com, accessed on September 10th, 2024. ABSTRACT Arthritic diseases are a significant global health challenge, highlighting the urgent need for innovative ...
Seif Ehab, Ola A. Gaser, Atif Abdulwahab A. Oyouni, Nader Kameli, Faisal Alzahrani, Ahmed Abdal Dayem   +5 more
wiley   +1 more source

Methods and Challenges in Purifying Drug‐Loaded Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.
ABSTRACT Extracellular vesicles (EV) have emerged as promising nanocarriers for drug delivery. However, the efficient loading of therapeutic molecules into EV and the subsequent purification of drug‐loaded EV from unloaded drugs remain significant challenges. This review explores the most used methods for EV purification, meaning the separation of drug‐
Marie Auquière, Giulio G. Muccioli, Anne des Rieux   +2 more
wiley   +1 more source