Results 21 to 30 of about 115 (79)

Orijini farklı kırmızılardan elde edilen laktik asit bakterileri ile mayaların tanımlanması ve keçi sütünden kımız üretimi. [PDF]

, 2015
Kırgızistan, Türkmenistan, Moğolistan, Tataristan, Rusya ve Türkiye'den temin edilen toplamda 32 adet kımız örneklerinden laktik asit bakterileri ve mayalar izole edilmiştir.
Akpınar, Aslı
core  

Large-Scale Production and Therapeutic Evaluation of Exosomes for Cancer Treatment

Thoracic Research and Practice
INTRODUCTION: Lung cancer remains one of the most prevalent and deadly malignancies worldwide, representing a major global health challenge. According to the latest global cancer statistics, lung cancer accounts for approximately 11.6% of all new cancer ...
Ilgin Kimiz-Gebologlu, Suphi S. Oncel
doaj   +1 more source

Exosomal Oleic Acid Promotes Lymphangiogenesis and Nodal Metastasis in Cervical Cancer via the AKT/mTOR Pathway

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Cervical cancer exosomes deliver SCD‐dependent oleic acid to LECs, activating AKT/mTOR to drive VEGF‐independent lymphangiogenesis and nodal metastasis, identifying exosomal OA as a therapeutic target. ABSTRACT Cervical cancer (CC) exhibits a pronounced tropism for regional lymphatic dissemination, a process driven by tumor‐associated lymphangiogenesis.
Jinqiu Li, Xiaojing Huang, Guzhalinuer Abulizi, Ayshamgul Hasim   +3 more
wiley   +1 more source

RVG‐Modified BMSCs‐Derived Small Extracellular Vesicles Loaded With miR‐21 Alleviate Neuronal Injury Resulted From Excessive Autophagy via Targeting PTEN/Akt/mTOR Pathway After Cerebral Ischaemia

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
Bioengineered brain targeting RVG‐modified BMSCs‐derived small extracellular vesicles loaded with miR‐21 alleviate excessive autophagic neuronal injury after cerebral ischaemia via PTEN/Akt/mTOR pathway. ABSTRACT Ischaemic stroke (IS) leads to tragic disability and high adult mortality, while there are limited therapeutic measures for it.
Yiyang Li, Jiacheng Hu, Jinfen Chen, Manfei Zhou, Mingchun Liao, Yayue Yang, Jiahao Zhou, Yan Han, Bin Wang, Yonghua Zhao   +9 more
wiley   +1 more source

Nanoparticle-Based Therapeutic Strategies in Respiratory Diseases: Current Approaches and Future Perspectives

Thoracic Research and Practice
INTRODUCTION: Respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis, and acute respiratory distress syndrome (ARDS) remain major global health challenges, causing significant morbidity and mortality ...
Ozge Cinar, Ilgin Kimiz-Gebologlu, Suphi S. Oncel   +2 more
doaj   +1 more source

From Mesenchymal Stromal Cells to Extracellular Vesicles: Scalable Strategies for Ovarian Stroma Regeneration

Molecular Reproduction and Development, Volume 93, Issue 5, May 2026.
ABSTRACT Ovarian aging is characterized by the reduction of the follicular pool and a progressive loss in oocyte quality. Although these changes have initially been attributed to oocyte alterations, increasing evidence indicates that stromal deterioration plays a central role in this process.
Stefhani Martins Barcelos, Amandda Évelin Silva‐Carvalho, Felipe Perecin, Juliana Lott Carvalho   +3 more
wiley   +1 more source

Hydrogel Embedding of Mesenchymal Stem Cells Supports Extracellular Vesicle Production

Biotechnology and Bioengineering, Volume 123, Issue 4, Page 939-949, April 2026.
This study investigates the effects of 3D culture conditions on extracellular vesicle (EV) production by mesenchymal stem cells (MSCs) in a gelatin‐based hydrogel matrix (GelMA). The EVs from both conditions were found to have similar morphological, molecular, and functional properties, but 3D cultures produced more total EVs per volume.
Rachel K. Moen, Gabriella Faircloth, Nicole T. Marguerite, Mariachiara Conti, Ethan S. Lippmann, Jamey D. Young   +5 more
wiley   +1 more source

MSC-Exosomes as Novel Therapeutics in Asthma and Allergic Airway Inflammation

Thoracic Research and Practice
INTRODUCTION: Allergic respiratory diseases, including asthma and allergic rhinitis, are chronic inflammatory diseases that affect millions of people worldwide and constitute a significant health problem.1 These diseases are characterized by airway ...
Sevval Kurt, Ilgin Kimiz-Gebologlu, Suphi S. Oncel   +2 more
doaj   +1 more source

Terapötik amaçlı kullanılan eksozomların kontrollü biyoreaktör ortamında üretilmesinin ve izolasyonunun optimizasyonu [PDF]

, 2023
Mühendislik Fakültesi, Biyomühendislik A.B.D. Araştırma ProjesiAraştırma Projesi elektronik ortamda bulunmaktadır.Nanopartiküler taşıyıcı sistemler, taşıdıkları ilacı ya da antijenik materyali serumdaki enzimlerden koruyan, ideal olarak 10-100 nm ...
Öncel, Suphi Ş.
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Microalgae-derived biomolecule and nanoparticle conjugates: Emerging therapeutic platforms for cancer treatment

OpenNano
Nanoparticle-based drug delivery systems have the potential to provide a promising platform for overcoming the limitations of therapeutics in cancer treatment, thanks to advantages such as controlled release, tumor targeting, and reduced systemic ...
Ozge Cinar, Ilgin Kimiz-Gebologlu, Sevval Kurt, Suphi S. Oncel   +3 more
doaj   +1 more source