Results 41 to 50 of about 5,527 (160)

Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao, Sinan Ai, Yaoxian Wang, Yuning Liu, Jingwei Zhou, Qingqing Liu, Xu Wang, Danting Li, Xin Li, Lin Wang, Jinyi Hou, Liang Peng, Zhen Wang   +12 more
wiley   +1 more source

Combining ability × environment interaction and genetic analysis for agronomic traits in safflower (Carthamus tinctorius L.): biplot as a tool for diallel data

Acta Agriculturae Slovenica, 2017
Combining ability × environment interaction is considerable to identify the effect of environment on the combining ability and gene action of the traits to select appropriate parents for safflower hybrid production.
Pooran Golkar, Ehsan Shahbazi, Mojtaba Nouraein   +2 more
doaj   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Hypoparathyroidism: an uncommon adverse effect of treatment with durvalumab

Endocrine Oncology, 2023
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies approved for the treatment of numerous cancer types. Toxicities induced by ICIs may affect any organ system and manifest as endocrinopathy.
Alexander Kreze, Matěj Homer, Tereza Barešová, Kristina Klemperová   +3 more
doaj   +1 more source

Using ANIMAL‐SPOT Deep Learning Framework to Identify Call Types in Killer Whales

Marine Mammal Science, Volume 42, Issue 2, April 2026.
ABSTRACT Killer whales use complex vocalizations to maintain social structure and coordinate behavior, yet automated classification of call types remains challenging due to overlapping calls and structural similarity among call types. I evaluated the performance of the deep learning framework ANIMAL‐SPOT for identifying killer whale call types from raw
Olga A. Filatova
wiley   +1 more source

Protein-Bound Uremic Toxin Profiling as a Tool to Optimize Hemodialysis. [PDF]

PLoS ONE, 2016
AIM:We studied various hemodialysis strategies for the removal of protein-bound solutes, which are associated with cardiovascular damage. METHODS:This study included 10 patients on standard (3 x 4 h/week) high-flux hemodialysis.
Sunny Eloot, Daniel Schneditz, Tom Cornelis, Wim Van Biesen, Griet Glorieux, Annemie Dhondt, Jeroen Kooman, Raymond Vanholder   +7 more
doaj   +1 more source

A Novel Topical Emollient Plus for Canine Atopic Dermatitis: A Clinical Trial Assessing Efficacy and User Acceptance

Veterinary Dermatology, Volume 37, Issue 2, Page 293-305, April 2026.
Background: Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While “emollient plus” formulations are widely used in human atopic dermatitis, their role in cAD remains underexplored. Hypothesis/Objectives: To evaluate the clinical efficacy and
Beatriz Fernandes, António Caldeira Mendes, Susana Paula Alves, Vanessa Schmidt, Ana Filipa Bizarro, Marta Pinto, Hugo Pereira, Joana Marto, Ana Mafalda Lourenço   +8 more
wiley   +1 more source

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source

Triazine‐Naphthalimide Cage for the Recognition of Nucleotides and Parallel G‐Quadruplex

ChemistryEurope, Volume 4, Issue 3, March 2026.
A cage‐like receptor is designed by combining a triazine‐based macrocycle with a naphthalimide dye. The modular construction enables the recognition of various sites on the G‐quadruplex, specifically the phosphate residues and guanine quartets. This design approach provides strong and selective binding of parallel G‐quadruplex over double‐stranded DNA ...
Maryam Akhgar, Evgeny A. Kataev
wiley   +1 more source

Formation of Condition‐Dependent Alpha‐Synuclein Fibril Strain in Artificial Cerebrospinal Fluid

Advanced Science, Volume 13, Issue 7, 3 February 2026.
α‐synuclein aggregation in artificial cerebrospinal fluid (aCSF) leads to a distinct conformation with an electron density pocket motif found in aggregates from PD and MSA patients. Such fibrils has low stability outside the reaction conditions, hinting about the influence of cerebrospinal fluid components not only on the formation, but also on the ...
Rūta Sniečkutė, Darius Šulskis, Arūnė Jocytė, Urtė Venclovaitė, Rimgailė Tamulytė, Mantas Žiaunys, Vytautas Smirnovas, Andrius Sakalauskas   +7 more
wiley   +1 more source