Results 131 to 140 of about 79,611 (233)
HSCB, a co-chaperone in mitochondrial iron-sulfur cluster biogenesis, is a novel candidate gene for congenital sideroblastic anemia [PDF]
, 2017 Congenital sideroblastic anemias (CSA) are inherited diseases resulting from defects in heme biosynthesis, mitochondrial iron-sulfur cluster (ISC) assembly, or mitochondrial translation.
Crispin, Andrew
core
MedComm, Volume 7, Issue 4, April 2026.CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley +1 more source
Efecto citotóxico de Physalis peruviana (capulí) en cáncer de colon y leucemia mieloide crónica
Anales de la Facultad de Medicina, 2006 Objetivo: Determinar la actividad citotóxica de Physalis peruviana en las líneas colo-205 (cáncer de colon) y K562 (leucemia mieloide crónica). Diseño: Estudio experimental.
David Zavala +4 more
doaj
MedComm, Volume 7, Issue 4, April 2026.Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao +6 more
wiley +1 more source
MPRAnalyze: statistical framework for massively parallel reporter assays. [PDF]
, 2019 Massively parallel reporter assays (MPRAs) can measure the regulatory function of thousands of DNA sequences in a single experiment. Despite growing popularity, MPRA studies are limited by a lack of a unified framework for analyzing the resulting data ...
Ahituv, Nadav +5 more
core
Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases
MedComm, Volume 7, Issue 4, April 2026.Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang +3 more
wiley +1 more source
ChemistryOpen, Volume 15, Issue 4, April 2026.Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel +5 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2018 目的研究姜黄素诱导自噬对K562细胞增殖的影响。方法采用1、5、10、20和40μM/L姜黄素及自噬抑制剂3-MA作用于K562细胞24h,采用MTT实验观察K562细胞增殖变化情况,随后采用Western-blot检测自噬标志蛋白LC3-II/LC3-I变化水平;同时Western blot分析p53,p21和p27表达变化。结果姜黄素能以时间、剂量依赖性方式抑制K562细胞增殖,与3-MA对照组相比,LC3-II/LC3-I比值显著上升,姜黄素诱导K562细胞周期停滞,上调p53 ...
于波海, 于鑫, 王鑫, 滕旭
doaj
RNA 干扰 mPGES-1 基因对 K562/A 细胞增殖及凋亡的影响
Zhongshan Daxue xuebao. Yixue kexue ban, 2020 【目的】探讨RNA干扰膜结合型前列腺素E2合酶1（mPGES-1）对阿霉素耐药的人红白血病细胞株K562/A细胞增殖、凋亡及耐药性的影响及其可能的机制。【方法】通过RNA干扰技术抑制K562/A细胞中mPGES-1表达。分组：①未处理组（K562/A），②干扰后的阴性对照组（K562/A-NC），③干扰组（K562/A-KD），④干扰后加入外源性PGE2组（K562/A-KD+PGE2）；CCK-8法检测细胞活力；流式细胞术检测细胞凋亡；ELISA法检测PGE2浓度；Western blot检测蛋白水平。
邱梦 +7 more
doaj
ChemistryOpen, Volume 15, Issue 4, April 2026.The new 2‐benzoylpyridine 4‐(bicyclo[2.2.1]hept‐2‐yl)thiosemicarbazone (HL) and its copper(II), nickel(II), cobalt(III), and iron(III) coordination compounds [Cu(L)Cl] (1), [Cu(L)NO3] (2), {[Cu(L)(Cl2CHCOO)]}n (3), [Ni(HL)2](NO3)2 (4), [Fe(L)2]NO3 (5), [Co(L)2]NO3 (6) were obtained.
Ianina Graur +6 more
wiley +1 more source