Results 121 to 130 of about 79,611 (233)

Grandisin induces apoptosis in leukemic K562 cells

Brazilian Journal of Pharmaceutical Sciences, 2017
In this study, the potential antileukemic activity of grandisin, a lignan extracted from Piper solmsianum, was evaluated against the leukemic line K562.
Alane Pereira Cortez, Elizabeth Gomes Paulino Menezes, Polyana Lopes Benfica, Alexandre Pereira dos Santos, Larissa Moreira Cleres, Higor de Oliveira Ribeiro, Eliana Martins Lima, Massuo Jorge Kato, Marize Campos Valadares   +8 more
doaj   +1 more source

Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

Advanced Science, Volume 13, Issue 24, 27 April 2026.
Chronic myeloid leukemia blast phase (CML‐BP) poses a severe therapeutic challenge. This study reveals that the super‐enhancer‐driven transcription factors SOX4 and SMAD3 form a cooperative axis critical for disease progression. They co‐activate the oncogenic kinase AXL and promote phospholipid remodeling via LPCAT1 to facilitate its signaling ...
Enzhe Lou, Peilong Lai, Guanjie Peng, Bo Lu, Lizhen Jiang, Xinyue Li, Jinghong Chen, Ladi Mo, Qiong Mao, Haichuan Zhang, Jinxin Fang, Yi Meng, Aochu Liu, Yingyin Gao, Andong Huang, Wenhui Lin, Shiwen Hu, Zerong Guan, Xiaolan Ye, Zhenguo Liu, Liling Jiang, Yueyuan Zheng, Xianping Shi   +22 more
wiley   +1 more source

The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells. [PDF]

, 2020
Background:Evasion from programmed cell death is a hallmark of cancer and can be achieved in cancer cells by overexpression of inhibitor of apoptosis proteins (IAPs).
Craver, Brianna M, Fleischman, Angela G, Huynh, Christy, Morse, Sarah J, Nguyen, Hellen, Nguyen, Jenny, Nguyen, Thanh Kim   +6 more
core  

NanoLoop: A Deep Learning Framework Leveraging Nanopore Sequencing for Chromatin Loop Prediction

Advanced Science, Volume 13, Issue 24, 27 April 2026.
Chromatin loops are central to gene regulation and 3D genome organization. Leveraging Nanopore sequencing's ability to jointly capture DNA sequence and methylation, we present NanoLoop, the first framework for genome‐wide chromatin loop prediction using Nanopore data.
Wenjie Huang, Li Tang, Matthew C. Hill, Yonghao Zhang, Jun Xie, Min Li   +5 more
wiley   +1 more source

Effect of interaction of magnetic nanoparticles of Fe3O4 and artesunate on apoptosis of K562 cells

International Journal of Nanomedicine, 2011
Ying Wang1, Yuxiang Han1, Yingying Yang1, Jingci Yang1, Xiaonan Guo1, Jingnan Zhang1, Ling Pan1, Guohua Xia2, Baoan Chen21Department of Hematology, the 2nd Hospital of Hebei Medical University, People’s Republic of China; 2Department of ...
Wang Y, Han Y, Yang Y, Yang J, Guo X, Zhang J, Pan L, Xia G, Chen B   +8 more
doaj  

Epidemiology and Recurrence of Sigmoid Volvulus: Analysis of Health Insurance Claims Data in Japan

DEN Open, Volume 6, Issue 1, April 2026.
• An annual incidence rate of sigmoid volvulus (SV) was 0.0159% (15.9/100,000). • SV incidence was significantly associated with men, constipation, and high grades of disability in the multivariable analysis. • After endoscopic reduction, the cumulative recurrence rate within 2 years was 35.6%. ABSTRACT Objectives Sigmoid volvulus (SV) is rare in Japan,
Masaaki Yamada, Michikazu Sekine, Haruka Fujinami, Yuchi Motofuji, Eiji Shinno   +4 more
wiley   +1 more source

Manufacturing and clinical applications of non‐CAR‐T immune effector cells

Transfusion, EarlyView.
Thane Kubik, Theodros Mamo, David H. McKenna   +2 more
wiley   +1 more source

Beyond miRNA Cargo Profiles: Anti‐Inflammatory Roles of Extracellular Vesicle‐Enriched miRNAs Derived From Human Intervertebral Disc Cells Unveiled by Functional Testing

Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.
ABSTRACT Intervertebral disc (IVD) degeneration is a leading cause of chronic low back pain and a major contributor to global disability. Understanding the molecular mechanisms underlying this condition is essential for developing targeted therapies. Among these mechanisms, microRNAs (miRNAs) have emerged as critical post‐transcriptional regulators of ...
Li Li, Aiwei Sun, Saber Ghazizadeh, Hadil Al‐Jallad, Kirby Upshaw, Saleh Alfaisali, Jean Ouellet, Peter Jarzem, Hosni Cherif, Lisbet Haglund   +9 more
wiley   +1 more source

Anti-proliferative and apoptotic effects of Lovastatin on K562 Erthromyloidy cancer cell line

مجله دانشگاه علوم پزشکی گرگان, 2017
Background and Objective: Lovastatin is a HMG-CoA reductase inhibitor and used for the treatment of hypercholesterolemia. Inhibition of HMG-CoA reductase results in inhibiting the activity of the Ras proto-oncogene that has mutations in most cancers ...
M Vaezi, M Mohammadzadeh, Y Pazhang
doaj  

Porphyromonas gingivalis Suppresses Interferon‐Gamma Signaling in Macrophages Through a Contact‐Dependent, Gingipain‐Mediated Mechanism

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
This study reveals that Porphyromonas gingivalis suppresses IFN‐γ signaling by downregulating STAT1 in macrophages. Gingipain protease activity and the Type IX Secretion System are essential for this immune evasion mechanism. These findings identify a novel bacterial strategy for host immune suppression and suggest new therapeutic targets for P ...
Shotaro Abe, Jun Ohshima, Masayoshi Morita, Nobutake Tanaka, Mikako Hayashi   +4 more
wiley   +1 more source