Results 141 to 150 of about 79,611 (233)
HematologyBackground Imatinib (IM) is the primary treatment for patients with chronic-phase CML (CML-CP). However, an increasing number of CML-CP patients have developed resistance to IM.
Yaqin Jiang +8 more
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Solamargine induces acute myeloid leukemia differentiation through TLR8 activation
VIEW, Volume 7, Issue 2, April 2026.SM, a steroidal alkaloid from Solanum nigrum L. has shown anticancer effect on various kinds of human cancer cells, yet its effect on leukemia cells remains unclear. This study examines antileukemic activities of SM in AML cells. Results indicate SM inhibits growth and promotes apoptosis of AML cells.
Qiaoyan Han +11 more
wiley +1 more source
外源性SHIP基因表达抑制生长因子介导的 K562细胞增殖及Akt磷酸化
Zhongshan Daxue xuebao. Yixue kexue ban, 2009 【目的】 探讨SHIP基因对IL-3诱导K562细胞系增殖的抑制作用,阐明SHIP对K562细胞作用的机制65377;【方法】 将慢病毒质粒pReceiver-Lv31-FIV和pReceiver-Lv31-SHIP转染K562细胞;转染细胞与IL-3共培养,Western blot法检测K562细胞Akt磷酸化;观察转染野生型SHIP基因对K562细胞增殖的影响;末端脱氧核苷酸转移酶介导的dUTP缺失末端标记(TUNEL)法检测细胞凋亡65377;【结果】 重组慢病毒载体pReceiver-Lv31 ...
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Roles of TIF1β in Leukemic Stem Cell Through SETDB1‐Dependent and Independent Mechanisms
Cancer Science, Volume 117, Issue 4, Page 896-903, April 2026.In leukemic stem cell, BCR::ABL cooperates with TIF1β to open chromatin at oncogenes and close chromatin at differentiation regulators, driving leukemic reprogramming. In TIF1β‐deficient stem cell, the loss of TIF1β inverts this balance, showing closed chromatin at oncogenes and open chromatin at differentiation regulators.
Mariko Morii, Sho Kubota, Goro Sashida
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反义 BCR/ABL 寡核苷酸体外抑制 K562 细胞的研究
Zhongshan Daxue xuebao. Yixue kexue ban, 1999 目的: 探讨反义 BCR 和 ABL 融合基因( BCR/ABL 融合基因)寡核苷酸体外抑制 K562 细胞的作用及机制。方 法: 采用 K562细胞培养,观察反义 BCR/ABL 寡核苷酸体外对 K562 细胞数、台盼蓝拒染率及克隆形成等的影响。结果: 经反 义 BCR/ABL 寡核苷酸 b3a2(AS-b3a2)处理后培养 8 d的 K562克隆抑制率达60. 69%,液体培养中细胞数从 24 h 开始较对照 组减少,细胞存活率从 8 h 开始即较对照组明显下降, BCR/ABL 寡核苷酸 b2a2(
戴木水 戴丽君 洪文德 罗绍凯 彭爱华 王顺清
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Cell Proliferation, Volume 59, Issue 4, April 2026.Advancements in the generation of human pluripotent stem cell‐derived natural killer (PSC‐NK) cells have attracted considerable attention within the biomedical research community, offering a promising off‐the‐shelf technique for universal immune therapy.
Qianwen Chen +5 more
wiley +1 more source
Cancer Management and Research, 2018 Lan Zhang, Weihua Zhang Department of Haematology, First Hospital of Shanxi Medical University, Taiyuan 030001, China Background: NUDT21 is a mammalian precursor mRNA(pre-mRNA) 3’ end processing factor and plays an important role in the selection ...
Zhang L, Zhang WH
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Roles of extracellular vesicles in the pathogenesis of chronic myeloid leukemia. [PDF]
J Physiol BiochemHrdinova T, Kupcova Skalnikova H.
europepmc +1 more source