A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo [PDF]
, 2011 Mutations in WNK1 and WNK4 kinase genes have been shown to cause a human hereditary hypertensive disease, pseudohypoaldosteronism type II (PHAII). We previously discovered that WNK kinases phosphorylate and activate OSR1/SPAK kinases that regulate renal ...
Alessi, Dario R. +7 more
core +3 more sources
Computation of Pump-Leak Flux Balance in Animal Cells
Cellular Physiology and Biochemistry, 2014 Background/Aims: Many vital processes in animal cells depend on monovalent ion transport across the plasma membrane via specific pathways. Their operation is described by a set of nonlinear and transcendental equations that cannot be solved analytically.
Igor A. Vereninov +4 more
doaj +1 more source
Sublethal salinity stress contributes to habitat limitation in an endangered estuarine fish. [PDF]
, 2016 As global change alters multiple environmental conditions, predicting species' responses can be challenging without understanding how each environmental factor influences organismal performance.
Connon, Richard E +6 more
core +1 more source
Phosphonopeptides Revisited, in an Era of Increasing Antimicrobial Resistance [PDF]
, 2020 Given the increase in resistance to antibacterial agents, there is an urgent need for the development of new agents with novel modes of action. As an interim solution, it is also prudent to reinvestigate old or abandoned antibacterial compounds to assess
Anderson, Rosaleen +8 more
core +2 more sources
Sex and species differences in epithelial transport in rat and mouse kidneys: Modeling and analysis
Frontiers in Physiology, 2022 The goal of this study was to investigate the functional implications of sex and species differences in the pattern of transporters along nephrons in the rat and mouse kidney, as reported by Veiras et al. (J Am Soc Nephrol 28: 3504–3517, 2017). To do so,
Melissa Maria Stadt +4 more
doaj +1 more source
Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures [PDF]
, 2014 Seizures are a common manifestation of acute neurologic insults in neonates and are often resistant to the standard antiepileptic drugs that are efficacious in children and adults.
Delpire E +7 more
core +1 more source
Coordinate modulation of Na-K-2Cl cotransport and K-Cl cotransport by cell volume and chloride [PDF]
American Journal of Physiology-Cell Physiology, 2002 Na-K-2Cl cotransporter (NKCC) and K-Cl cotransporter (KCC) play key roles in cell volume regulation and epithelial Cl− transport. Reductions in either cell volume or cytosolic Cl− concentration ([Cl−]i) stimulate a corrective uptake of KCl and water via NKCC, whereas cell swelling triggers KCl loss via KCC.
Christian, Lytle, Thomas, McManus
openaire +2 more sources
The logic of ionic homeostasis: Cations are for voltage, but not for volume. [PDF]
PLoS Computational Biology, 2019 Neuronal activity is associated with transmembrane ionic redistribution, which can lead to an osmotic imbalance. Accordingly, activity-dependent changes of the membrane potential are sometimes accompanied by changes in intracellular and/or extracellular ...
Andrey V Dmitriev +2 more
doaj +1 more source
Sodium chloride transport of normal and dietary enlarged rat cecum in vitro [PDF]
, 1998 Sodium chloride transport across isolated cecum mucosa was investigated in normal rats and rats with adaptive cecum growth induced by dietary polyethylene glycol (PEG). The normal cecum absorbed CI in excess of Na with a small short-circuit current (Isc).
Loeschke, Klaus +2 more
core +1 more source
Frontiers in Molecular Neuroscience, 2021 The activation of chloride (Cl−)permeable gamma (γ)-aminobutyric acid type A(GABAA) receptors induces synaptic inhibition in mature and excitation in immature neurons. This developmental “switch” in GABA function controlled by its polarity depends on the
Wee Meng Lim +9 more
doaj +1 more source