Results 51 to 60 of about 354,242 (265)
eLife, 2018 Fast synaptic inhibition in the nervous system depends on the transmembrane flux of Cl- ions based on the neuronal Cl- driving force. Established theories regarding the determinants of Cl- driving force have recently been questioned.
Kira M Düsterwald +5 more
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Modeling glial contributions to seizures and epileptogenesis: cation-chloride cotransporters in Drosophila melanogaster. [PDF]
PLoS ONE, 2014 Flies carrying a kcc loss-of-function mutation are more seizure-susceptible than wild-type flies. The kcc gene is the highly conserved Drosophila melanogaster ortholog of K+/Cl- cotransporter genes thought to be expressed in all animal cell types.
Zeid M Rusan +2 more
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Barlowite as a canted antiferromagnet: theory and experiment [PDF]
Phys. Rev. B 92, 094417 (2015), 2014 We investigate the structural, electronic and magnetic properties of the newly synthesized mineral barlowite Cu4(OH)6FBr which contains Cu2+ ions in a perfect kagome arrangement. In contrast to the spin-liquid candidate herbertsmithite ZnCu3(OH)6Cl2, kagome layers in barlowite are perfectly aligned due to the different bonding environments adopted by F-
arxiv +1 more source
The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies
Journal of Pharmaceutical Analysis, 2023 The solute carrier family 12 (SLC12) of cation-chloride cotransporters (CCCs) comprises potassium chloride cotransporters (KCCs, e.g. KCC1, KCC2, KCC3, and KCC4)-mediated Cl− extrusion, and sodium potassium chloride cotransporters (N[K]CCs, NKCC1, NKCC2,
Shiyao Zhang +15 more
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PLoS ONE, 2017 Cation Chloride Cotransporters (CCCs) comprise secondary active membrane proteins mainly mediating the symport of cations (Na+, K+) coupled with chloride (Cl-). They are divided into K+-Cl- outward transporters (KCCs), the Na+-K+-Cl- (NKCCs) and Na+-Cl- (
Anna-Maria Hartmann +3 more
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Sex and species differences in epithelial transport in rat and mouse kidneys: Modeling and analysis
Frontiers in Physiology, 2022 The goal of this study was to investigate the functional implications of sex and species differences in the pattern of transporters along nephrons in the rat and mouse kidney, as reported by Veiras et al. (J Am Soc Nephrol 28: 3504–3517, 2017). To do so,
Melissa Maria Stadt +4 more
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Ab initio molecular dynamics calculations of ion hydration free energies [PDF]
Journal of Chemical Physics 130 (20), 204507 (2009), 2009 We apply ab initio molecular dynamics (AIMD) methods in conjunction with the thermodynamic integration or "lambda-path" technique to compute the intrinsic hydration free energies of Li+, Cl-, and Ag+ ions. Using the Perdew-Burke-Ernzerhof functional, adapting methods developed for classical force field applications, and with consistent assumptions ...
arxiv +1 more source
Role of the cation-chloride-cotransporters in the circadian system
Asian Journal of Pharmaceutical Sciences, 2021 The circadian system plays an immense role in controlling physiological processes in our body. The suprachiasmatic nucleus (SCN) supervises this system, regulating and harmonising the circadian rhythms in our body.
Shihan Salihu +5 more
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Computation of Pump-Leak Flux Balance in Animal Cells
Cellular Physiology and Biochemistry, 2014 Background/Aims: Many vital processes in animal cells depend on monovalent ion transport across the plasma membrane via specific pathways. Their operation is described by a set of nonlinear and transcendental equations that cannot be solved analytically.
Igor A. Vereninov +4 more
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The logic of ionic homeostasis: Cations are for voltage, but not for volume. [PDF]
PLoS Computational Biology, 2019 Neuronal activity is associated with transmembrane ionic redistribution, which can lead to an osmotic imbalance. Accordingly, activity-dependent changes of the membrane potential are sometimes accompanied by changes in intracellular and/or extracellular ...
Andrey V Dmitriev +2 more
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