Gene Expression Pattern of Peyer’s Patch Lymphocytes Exposed to Kagocel Suggests Pattern-Recognition Receptors Mediate Its Action [PDF]
Frontiers in Pharmacology, 2021 Kagocel is a synthetic carboxymethylcellulose derivative copolymerized with gossypol. Clinical data evidence its safety and efficiency for the treatment of flu and other viral infections via enhancement of interferon production. The gut-associated lymphoid tissue seems a likely site of kagocel action.
Alexander A. Andreev-Andrievskiy +11 more
openaire +4 more sources
The effect of Kagocel® on gene expression of Toll-like receptors of innate immunity in THP-1 human monocytes with different levels of differentiation [PDF]
Biological Products. Prevention, Diagnosis, Treatment, 2021 Kagocel® is used in Russia for the treatment of viral infections. In terms of its chemical structure, Kagocel® active ingredient is a copolymer of gossypol polyphenol and carboxymethylcellulose. The study investigated antiviral and cytokine-inducing activity of Kagocel®, as well as its toxic effects.
T. M. Sokolova, V. V. Poloskov
core +8 more sources
The potential roles of gossypol as anticancer agent: advances and future directions [PDF]
Chin Med, 2023 Gossypol, a polyphenolic aldehyde derived from cottonseed plants, has seen a transformation in its pharmaceutical application from a male contraceptive to a candidate for cancer therapy.
Calina, Daniela +7 more
core +3 more sources
Antiviral strategies against influenza virus: an update on approved and innovative therapeutic approaches [PDF]
Cell Mol Life SciInfluenza viruses still represent a great concern for Public Health by causing yearly seasonal epidemics and occasionally worldwide pandemics. Moreover, spillover events at the animal-human interface are becoming more frequent nowadays, also involving ...
Bonomini A., Loregian A., Mercorelli B.
core +2 more sources
Antiviral Activity of Kagocel® on the Model of Experimental Lethal Influenza Infection
Antibiotics and Chemotherapy, 2020 Despite the obvious advances in vaccination and therapy, influenza remains a poorly controlled infection with high morbidity and mortality. This study examined the antiviral activity of interferon inducer Kagocel on a mouse model of lethal influenza pneumonia.
V. V. Zarubaev +4 more
openaire +4 more sources
Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part II: Future compounds against influenza virus [PDF]
J Prev Med Hyg, 2014 In the first part of this overview, we described the life cycle of the influenza virus and the pharmacological action of the currently available drugs.
Amicizia, Daniela +4 more
core +3 more sources
Safety of the Russian antiviral drug Kagocel
Terapevticheskii arkhiv, 2017 The review gives summarized information on the preclinical data and clinical trials evaluating the safety of the antiviral drug Kagocel. It notes that the manufacturer of the drug pay special attention to the control of its impurity content. There is information on the development and validation of highly sensitive and specific high-performance liquid ...
T G Borovskaya
openaire +4 more sources
ANTIVIRAL EFFECT OF «KAGOCEL» SUBSTANCE IN VITRO ON INFLUENZA VIRUSES H1N1, H1N1PDM09 AND H3N2
Problems of Virology, 2019 Introduction. Active circulation of pandemic influenza and new variants of influenza H3N2 strains requires monitoring of antiviral efficacy of drugs permitted for influenza therapy in the Russian Federation. Purpose. Assessment of antiviral efficacy of «Kagocel» substance against influenza viruses H1N1, H1N1pdm09 and H3N2 in vitro. Material and methods.
I. T. Fediakina +4 more
openaire +5 more sources
Towards Automatic Evaluation of Health-Related CQA Data [PDF]
, 2014 The paper reports on evaluation of Russian community question answering (CQA) data in health domain. About 1,500 question-answer pairs were manually evaluated by medical professionals, in addition automatic evaluation based on reference disease-medicine ...
Beloborodov, A. +4 more
core +6 more sources
ПРОТИВОВИРУСНАЯ ТЕРАПИЯ ОРВИ И ГРИППА У ДЕТЕЙ В СТАЦИОНАРНЫХ УСЛОВИЯХ [PDF]
, 2018 Objective: to study the efficacy and safety of antiviral therapy for influenza and acute respiratory viral infection with Kagocel in children in a hospital.
A. Levina S. +7 more
core +4 more sources