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Antiviral therapy for influenza in high-risk outpatients: a multicenter observational study of routine clinical practice in Russia. [PDF]
Tokin I +9 more
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Rarely listed essential medicines in 158 national lists. [PDF]
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Evaluation of Kagocel Genotoxicity
Bulletin of Experimental Biology and Medicine, 2019Antiviral drug Kagocel in concentrations of 0.0008, 0.004, 0.02, 0.1, 0.5, and 2.5 mg/ml with or without metabolic activation does not induce gene mutations in S. typhimurium strains ТА98, ТА100, ТА1535, and ТА1537 and in a combination of E. coli strains pKM101 and uvrA.
A K, Zhanataev +7 more
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Medical alphabet, 2020
Introduction. Cytokines regulate intercellular and intersystem interactions and are involved in the development and prevention of various pathologies. Purposes of work were a comparative assessment of the dynamics of the levels of pro- and anti-inflammatory blood cytokines (TNF-α and IL‑10) in patients with community-acquired viral-bacterial pneumonia (
A. F. Popov +5 more
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Introduction. Cytokines regulate intercellular and intersystem interactions and are involved in the development and prevention of various pathologies. Purposes of work were a comparative assessment of the dynamics of the levels of pro- and anti-inflammatory blood cytokines (TNF-α and IL‑10) in patients with community-acquired viral-bacterial pneumonia (
A. F. Popov +5 more
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Experimental Assessment of the Effect of Kagocel on Reproductive Function in Pubertal Male Rats
Bulletin of Experimental Biology and Medicine, 2017We studied possible toxic effects of antiviral drug Kagocel on reproductive function in pubertal male rats. The drug was administered in therapeutic and 10-fold higher doses throughout the spermatogenesis cycle (48 days). Kagocel did not reduce mating and fertilizing capacities, did not suppress spermatogenesis, and had no toxic effects on the ...
T G, Borovskaya +4 more
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Eksperimental'naia i klinicheskaia farmakologiia, 2013
Fixed erythema--a kind of clinical and histopathologic reaction, fixed drug eruption. The purpose of the study--the study of characteristics of the cytokine profile in patients with erythema and the dynamics of the basal levels of proinflammatory and antiinflammatory cytokines during immunotherapy.
E V, Sorokina +3 more
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Fixed erythema--a kind of clinical and histopathologic reaction, fixed drug eruption. The purpose of the study--the study of characteristics of the cytokine profile in patients with erythema and the dynamics of the basal levels of proinflammatory and antiinflammatory cytokines during immunotherapy.
E V, Sorokina +3 more
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Toxicological Review, 2017
In experimental studies on rats (males, females) at their infantile stage starting from 10 days, a potential delayed toxic effect of the antiviral drug Kagocel on the reproductive system was studied. The drug was administered for 12 days in a therapeutic dose and at a dose 10-fold higher than the therapeutic one. Reproductive safety was estimated after
T. A. Borovskaya +4 more
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In experimental studies on rats (males, females) at their infantile stage starting from 10 days, a potential delayed toxic effect of the antiviral drug Kagocel on the reproductive system was studied. The drug was administered for 12 days in a therapeutic dose and at a dose 10-fold higher than the therapeutic one. Reproductive safety was estimated after
T. A. Borovskaya +4 more
openaire +1 more source
Bulletin of Experimental Biology and Medicine, 2015
The efficiency of cloning of bone marrow multipotent stromal cells (ECF-MSC) from CBA mice and the MSC counts in the femoral bone increased 24 h after a single in vivo (but not in vitro) injection of kagocel (active substance of antiviral drug Kagocel (®) ) 1.4 times (in response to 50-80 μg) and 4.6 times (in response to 250 μg).
Yu F, Gorskaya +4 more
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The efficiency of cloning of bone marrow multipotent stromal cells (ECF-MSC) from CBA mice and the MSC counts in the femoral bone increased 24 h after a single in vivo (but not in vitro) injection of kagocel (active substance of antiviral drug Kagocel (®) ) 1.4 times (in response to 50-80 μg) and 4.6 times (in response to 250 μg).
Yu F, Gorskaya +4 more
openaire +2 more sources
Bulletin of Experimental Biology and Medicine, 2017
Pretreatment with the active substance of antiviral preparation Kagocel, inductor of type I endogenous IFN, in a daily therapeutic dose (30 μg/mouse) 3 h prior to administration of S. typhimurium antigens to CBA mice reduced the number of bone marrow multipotent stromal cell (significantly increased by 3.2 times on the next day after antigen injection)
Yu F, Gorskaya +4 more
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Pretreatment with the active substance of antiviral preparation Kagocel, inductor of type I endogenous IFN, in a daily therapeutic dose (30 μg/mouse) 3 h prior to administration of S. typhimurium antigens to CBA mice reduced the number of bone marrow multipotent stromal cell (significantly increased by 3.2 times on the next day after antigen injection)
Yu F, Gorskaya +4 more
openaire +2 more sources

