Results 31 to 40 of about 48,573 (291)
Frontiers in Cellular Neuroscience, 2016 Granule cell dispersion (GCD) represents a pathological widening of the granule cell layer (GCL) in the dentate gyrus and it is frequently observed in patients with mesial temporal lobe epilepsy (MTLE).
Catarina Orcinha +20 more
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Cells, 2023 In the last 30 years, over 20 new anti-seizure medicines (ASMs) have been introduced into the market for the treatment of epilepsy using well-established preclinical seizure and epilepsy models. Despite this success, approximately 20–30% of patients with
Wolfgang Löscher, H. Steve White
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A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro [PDF]
, 2004 Basic cellular and network mechanisms underlying gamma frequency oscillations (30–80 Hz) have been well characterized in the hippocampus and associated structures.
A. Bibbig +33 more
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Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses [PDF]
, 2011 Adaptive forms of synaptic plasticity that reduce excitatory synaptic transmission in response to prolonged increases in neuronal activity may prevent runaway positive feedback in neuronal circuits.
Chang, Chun Yun +3 more
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Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations [PDF]
, 2003 Electrical coupling between pyramidal cell axons, and between interneuron dendrites, have both been described in the hippocampus. What are the functional roles of the two types of coupling?
Bibbig, A. +7 more
core +2 more sources
Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease. [PDF]
, 2019 The maintenance of genomic integrity is essential for normal cellular functions. However, it is difficult to maintain over a lifetime in postmitotic cells such as neurons, in which DNA damage increases with age and is exacerbated by multiple neurological
Adame, Anthony +8 more
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Structural basis of kainate subtype glutamate receptor desensitization
Nature, 2016 Glutamate receptors are ligand-gated tetrameric ion channels that mediate synaptic transmission in the central nervous system. They are instrumental in vertebrate cognition and their dysfunction underlies diverse diseases.
J. Meyerson +7 more
semanticscholar +1 more source
Neurobiology of Disease, 1994 A minority subset of cortical neurones exhibit kainate-activated Co2+uptake, a marker for AMPA/kainate receptor gated Ca2+-permeable channels. Consistent with enhanced Ca2+influx through these channels, Co2+-positive neurones are unusually vulnerable to ...
Hong-zhen Yin +3 more
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Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures [PDF]
, 2019 The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites.
Andrews, Peter M. +11 more
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Kainate receptor trafficking [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2011 AbstractKainate receptors (KARs) are ligand‐gated ion channels that can regulate neuronal network activity and are involved in processes ranging from neuronal development and differentiation to neurodegeneration and neuronal cell death. They are tetrameric assemblies which can comprise different subunit combinations and are differentially targeted to ...
Inmaculada M. González‐González +6 more
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