Results 11 to 20 of about 24,046 (180)

Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons. [PDF]

, 2002
International audienceThe relative contribution of kainate receptors to ongoing glutamatergic activity is at present unknown. We report the presence of spontaneous, miniature, and minimal stimulation-evoked excitatory postsynaptic currents (EPSCs) that ...
Crépel, Valérie, Tyzio, Roman, Cossart, Rosa, Epsztein, Jérôme, Hirsch, June, C., Becq, Hélène, Ben-Ari, Yehezkel   +6 more
core   +2 more sources

Cortical neurones exhibiting kainate-activated Co2+uptake are selectively vulnerable to AMPA/kainate receptor-mediated toxicity

Neurobiology of Disease, 1994
Kainate-activated Co2+uptake, a histochemical method that identifies cells bearing Ca2+-permeable AMPA/kainate receptors, labels approximately 15% of murine cortical neurones in cell culture.
Dorothy M. Turetsky, Lorella M.T. Canzoniero, Stefano L. Sensi, John H. Weiss, Mark P. Goldberg, Dennis W. Choi   +5 more
doaj   +1 more source

Simvastatin, edaravone and dexamethasone protect against kainate-induced brain endothelial cell damage

Fluids and Barriers of the CNS, 2020
Background Excitotoxicity is a central pathological pathway in many neurological diseases with blood–brain barrier (BBB) dysfunction. Kainate, an exogenous excitotoxin, induces epilepsy and BBB damage in animal models, but the direct effect of kainate on
Lilla Barna, Fruzsina R. Walter, András Harazin, Alexandra Bocsik, András Kincses, Vilmos Tubak, Katalin Jósvay, Ágnes Zvara, Patricia Campos-Bedolla, Mária A. Deli   +9 more
doaj   +1 more source

7-nitroindazole, a selective neuronal nitric oxide synthase inhibitore in vivo, prevents kainate-induced intrahippocampal neurotoxicity [PDF]

Archives of Biological Sciences, 2005
We investigated the effects of 7-nitroindazole (7-NI), a selective neuronal nitric oxide synthase inhibitor in vivo, on nitrite concentration after kainic acid injection unilaterally into the CA3 region of the rat hippocampus. The accumulation of nitrite,
Radenović Lidija Lj., Selaković Vesna, Božić Biljana   +2 more
doaj   +1 more source

Reduced Interhemispheric Coherence after Cerebellar Vermis Output Perturbation

Brain Sciences, 2020
Motor coordination and motor learning are well-known roles of the cerebellum. Recent evidence also supports the contribution of the cerebellum to the oscillatory activity of brain networks involved in a wide range of disorders.
Elena Laura Georgescu Margarint, Ioana Antoaneta Georgescu, Carmen-Denise-Mihaela Zahiu, Alexandru Răzvan Șteopoaie, Stefan-Alexandru Tirlea, Daniela Popa, Ana-Maria Zagrean, Leon Zagrean   +7 more
doaj   +1 more source

Role of brain glycogen in the response to hypoxia and in susceptibility to epilepsy

Frontiers in Cellular Neuroscience, 2015
Although glycogen is the only carbohydrate reserve of the brain, its overall contribution to brain functions remains unclear. It has been proposed that glycogen participates in the preservation of such functions during hypoxia.
Juan Carlos eLópez Ramos, Jordi eDuran, Agnes eGruart, Joan J Guinovart, Joan J Guinovart, José M Delgado-García   +5 more
doaj   +1 more source

Mediation of Sinusoidal Network Oscillations in the Locus Coeruleus of Newborn Rat Slices by Pharmacologically Distinct AMPA and KA Receptors

Brain Sciences, 2022
Brain control by locus coeruleus (LC) neurons involves afferent glutamate (Glu) inputs. In newborns, LC Glu receptors and responses may be sparse due to immaturity of the brain circuits providing such input.
Bijal Rawal, Klaus Ballanyi
doaj   +1 more source

Animal Models of Drug-Resistant Epilepsy as Tools for Deciphering the Cellular and Molecular Mechanisms of Pharmacoresistance and Discovering More Effective Treatments

Cells, 2023
In the last 30 years, over 20 new anti-seizure medicines (ASMs) have been introduced into the market for the treatment of epilepsy using well-established preclinical seizure and epilepsy models. Despite this success, approximately 20–30% of patients with
Wolfgang Löscher, H. Steve White
doaj   +1 more source

Effects of glutamate receptor activation on NG2-glia in the rat optic nerve [PDF]

, 2009
NG2-glia are a substantial population of cells in the central nervous system (CNS) that can be identified by their specific expression of the NG2 chondroitin sulphate (CSPG).
Hubbard, Paul S., Hamilton, Nicola; id_orcid, Hamilton, N., Butt, Arthur, Hubbard, Paul, Butt, Arthur M., Hamilton, N, Hubbard, P., Butt, AM   +8 more
core   +1 more source

Seizure-induced motility of differentiated dentate granule cells is prevented by the central Reelin fragment

Frontiers in Cellular Neuroscience, 2016
Granule cell dispersion (GCD) represents a pathological widening of the granule cell layer (GCL) in the dentate gyrus and it is frequently observed in patients with mesial temporal lobe epilepsy (MTLE).
Catarina Orcinha, Catarina Orcinha, Catarina Orcinha, Catarina Orcinha, Gert Münzner, Gert Münzner, Gert Münzner, Johannes Gerlach, Johannes Gerlach, Johannes Gerlach, Antje Kilias, Antje Kilias, Antje Kilias, Marie Follo, Marie Follo, Ulrich Egert, Ulrich Egert, Carola A Haas, Carola A Haas, Carola A Haas, Carola A Haas   +20 more
doaj   +1 more source