Results 11 to 20 of about 47,334 (259)
Kainate receptors in health and disease. [PDF]
Neuron, 2013 Our understanding of the molecular properties of kainate receptors and their involvement in synaptic physiology has progressed significantly over the last 30 years. A plethora of studies indicate that kainate receptors are important mediators of the pre- and postsynaptic actions of glutamate, although the mechanisms underlying such effects are still ...
J. Lerma, Joana M Marques
semanticscholar +4 more sources
Kainate Receptors: Role in Epilepsy [PDF]
Frontiers in Molecular Neuroscience, 2018 Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain seizures and, after repetitive treatments, as a chronic model of temporal lobe epilepsy (TLE), with similar features to those observed in human patients ...
Rafael Falcón-Moya1 +2 more
semanticscholar +5 more sources
Neurobiology of Disease, 2022 Background: Epilepsy is one of the most common brain disorder and, despite the possible use of several therapeutic options, many patients continue to have seizures for their entire lifespan and they need new therapeutic approaches.
Elisa Landucci +6 more
doaj +2 more sources
Cell Reports, 2017 Kainate receptors are members of the glutamate receptor family that regulate synaptic function in the brain. They modulate synaptic transmission and the excitability of neurons; however, their contributions to neural circuits that underlie behavior are ...
Jian Xu +10 more
doaj +2 more sources
Neurobiology of Disease, 2014 Prostaglandin E2 (PGE2) regulates membrane excitability, synaptic transmission, plasticity, and neuronal survival. The consequences of PGE2 release following seizures has been the subject of much study.
Asheebo Rojas +5 more
doaj +2 more sources
The synaptic activation of kainate receptors
Nature, 1997 L-Glutamate, the principal excitatory neurotransmitter in the vertebrate central nervous system, acts on three classes of ionotropic glutamate receptors, named after the agonists AMPA, NMDA and kainate. AMPA receptors are known to mediate fast synaptic responses and NMDA receptors to mediate slow synaptic responses at most excitatory synapses in the ...
M. Vignes, G. Collingridge
semanticscholar +3 more sources
Trafficking of Kainate Receptors [PDF]
Membranes, 2014 Ionotropic glutamate receptors (iGluRs) mediate the vast majority of excitatory neurotransmission in the central nervous system of vertebrates. In the protein family of iGluRs, kainate receptors (KARs) comprise the probably least well understood receptor class.
Pahl, Steffen +3 more
openaire +4 more sources
Cochlear Kainate Receptors [PDF]
Journal of the Association for Research in Otolaryngology, 2012 Synaptic transmission between the cochlear hair cell and its afferent fiber is mediated by glutamate receptors. While kainate receptors are known to be present in the spiral ganglion, little is known of their distribution or functional role. We have detected all five kainate receptor subunits in the mouse cochlea with quantitative RT-PCR and with ...
Marcello, Peppi +2 more
openaire +2 more sources
A predictive epilepsy index based on probabilistic classification of interictal spike waveforms. [PDF]
PLoS ONE, 2018 Quantification of interictal spikes in EEG may provide insight on epilepsy disease burden, but manual quantification of spikes is time-consuming and subject to bias.
Jesse A Pfammatter +4 more
doaj +1 more source
The Perils of Navigating Activity-Dependent Alternative Splicing of Neurexins
Frontiers in Molecular Neuroscience, 2021 Neurexins are presynaptic cell-adhesion molecules essential for synaptic function that are expressed in thousands of alternatively spliced isoforms. Recent studies suggested that alternative splicing at splice site 4 (SS4) of Nrxn1 is tightly regulated ...
Kif Liakath-Ali +3 more
doaj +1 more source