Results 21 to 30 of about 22,259 (219)
Fluids and Barriers of the CNS, 2020 Background Excitotoxicity is a central pathological pathway in many neurological diseases with blood–brain barrier (BBB) dysfunction. Kainate, an exogenous excitotoxin, induces epilepsy and BBB damage in animal models, but the direct effect of kainate on
Lilla Barna +9 more
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7-nitroindazole, a selective neuronal nitric oxide synthase inhibitore in vivo, prevents kainate-induced intrahippocampal neurotoxicity [PDF]
Archives of Biological Sciences, 2005 We investigated the effects of 7-nitroindazole (7-NI), a selective neuronal nitric oxide synthase inhibitor in vivo, on nitrite concentration after kainic acid injection unilaterally into the CA3 region of the rat hippocampus. The accumulation of nitrite,
Radenović Lidija Lj. +2 more
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Reduced Interhemispheric Coherence after Cerebellar Vermis Output Perturbation
Brain Sciences, 2020 Motor coordination and motor learning are well-known roles of the cerebellum. Recent evidence also supports the contribution of the cerebellum to the oscillatory activity of brain networks involved in a wide range of disorders.
Elena Laura Georgescu Margarint +7 more
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Role of brain glycogen in the response to hypoxia and in susceptibility to epilepsy
Frontiers in Cellular Neuroscience, 2015 Although glycogen is the only carbohydrate reserve of the brain, its overall contribution to brain functions remains unclear. It has been proposed that glycogen participates in the preservation of such functions during hypoxia.
Juan Carlos eLópez Ramos +5 more
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Brain Sciences, 2022 Brain control by locus coeruleus (LC) neurons involves afferent glutamate (Glu) inputs. In newborns, LC Glu receptors and responses may be sparse due to immaturity of the brain circuits providing such input.
Bijal Rawal, Klaus Ballanyi
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Synaptic Targeting of Kainate Receptors [PDF]
Cerebral Cortex, 2014 When native and recombinant kainate receptors (KARs) are compared, there is a mismatch in several of their functional properties. While both generate currents, synaptic responses mediated by KARs have rarely observed in cultured hippocampal neurons.
Palacios-Filardo, Jon +2 more
openaire +3 more sources
Cells, 2023 In the last 30 years, over 20 new anti-seizure medicines (ASMs) have been introduced into the market for the treatment of epilepsy using well-established preclinical seizure and epilepsy models. Despite this success, approximately 20–30% of patients with
Wolfgang Löscher, H. Steve White
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Effects of glutamate receptor activation on NG2-glia in the rat optic nerve [PDF]
, 2009 NG2-glia are a substantial population of cells in the central nervous system (CNS) that can be identified by their specific expression of the NG2 chondroitin sulphate (CSPG).
Hubbard, Paul S. +8 more
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Frontiers in Cellular Neuroscience, 2016 Granule cell dispersion (GCD) represents a pathological widening of the granule cell layer (GCL) in the dentate gyrus and it is frequently observed in patients with mesial temporal lobe epilepsy (MTLE).
Catarina Orcinha +20 more
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Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor
Cell Reports, 2016 Synaptic communication between neurons requires the precise localization of neurotransmitter receptors to the correct synapse type. Kainate-type glutamate receptors restrict synaptic localization that is determined by the afferent presynaptic connection.
Christoph Straub +10 more
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