Results 21 to 30 of about 24,046 (180)

Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor

Cell Reports, 2016
Synaptic communication between neurons requires the precise localization of neurotransmitter receptors to the correct synapse type. Kainate-type glutamate receptors restrict synaptic localization that is determined by the afferent presynaptic connection.
Christoph Straub, Yoav Noam, Toshihiro Nomura, Miwako Yamasaki, Dan Yan, Herman B. Fernandes, Ping Zhang, James R. Howe, Masahiko Watanabe, Anis Contractor, Susumu Tomita   +10 more
doaj   +1 more source

Cortical neurones with Ca2+permeable AMPA/kainate channels display distinct receptor immunoreactivity and are GABAergic

Neurobiology of Disease, 1994
A minority subset of cortical neurones exhibit kainate-activated Co2+uptake, a marker for AMPA/kainate receptor gated Ca2+-permeable channels. Consistent with enhanced Ca2+influx through these channels, Co2+-positive neurones are unusually vulnerable to ...
Hong-zhen Yin, Dorothy Turetsky, Dennis W. Choi, John H. Weiss   +3 more
doaj   +1 more source

Alternative Splicing of AMPA subunits in Prefrontal Cortical Fields of Cynomolgus Monkeys following Chronic Ethanol Self-Administration

Frontiers in Psychiatry, 2012
Functional impairment of the orbital and medial prefrontal cortex underlies deficits in executive control that characterize addictive disorders, including alcohol addiction.
Glen eAcosta, David P. Friedman, Kathleen A. Grant, Scott E Hemby   +3 more
doaj   +1 more source

Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy

eLife, 2017
Mesial temporal lobe epilepsy (mTLE) is the most common focal epilepsy in adults and is often refractory to medication. So far, resection of the epileptogenic focus represents the only curative therapy.
Philipp Janz, Niels Schwaderlapp, Katharina Heining, Ute Häussler, Jan G Korvink, Dominik von Elverfeldt, Jürgen Hennig, Ulrich Egert, Pierre LeVan, Carola A Haas   +9 more
doaj   +1 more source

Systematic evaluation of rationally chosen multitargeted drug combinations: a combination of low doses of levetiracetam, atorvastatin and ceftriaxone exerts antiepileptogenic effects in a mouse model of acquired epilepsy

Neurobiology of Disease, 2021
Epileptogenesis, the gradual process that leads to epilepsy after brain injury or genetic mutations, is a complex network phenomenon, involving a variety of morphological, biochemical and functional brain alterations. Although risk factors for developing
Lisa Welzel, David H. Bergin, Alina Schidlitzki, Friederike Twele, Marie Johne, Pavel Klein, Wolfgang Löscher   +6 more
doaj   +1 more source

Enhanced integration of newborn neurons after neonatal insults

Frontiers in Neuroscience, 2011
The production and integration of adult-generated neurons in the dentate gyrus is dramatically perturbed by a variety of pathological insults, including repetitive seizures and hypoxia/ischemia.
Phyllis C Pugh, Elena W Adlaf, Chaunsheng eZhao, Sean J Markwardt, Cristin F Gavin, Jacques I Wadiche, Linda eOverstreet-Wadiche   +6 more
doaj   +1 more source

Effect of 7-nitroindazoleon superoxide production and MnSOD activity in threat brain following kainate-induced neurotoxicity [PDF]

Archives of Biological Sciences, 2008
We investigated the effect of 7-nitroindazole (7-NI), a selective neuronal nitric oxide synthase inhibitor in vivo, on superoxide concentration as well its influence on mitochondrial MnSOD activity since this activity is associated with the production of
Radenović Lidija
doaj   +1 more source

Kainate induces various domain closures in AMPA and kainate receptors

, 2012
Ionotropic glutamate receptors are key players in fast excitatory synaptic transmission within the central nervous system. These receptors have been divided into three subfamilies: the N-methyl-d-aspartic acid (NMDA), 2-amino-3-(3-hydroxy-5-methyl-4 ...
Rabassa, Anna Ceravalls de, Gajhede, Michael, Ahring, Philip K., Frydenvang, Karla, Kastrup, Jette Sandholm, Venskutonyte, Raminta, Hald, Helle   +6 more
core   +1 more source

Oscillatory Cortical Activity in an Animal Model of Dystonia Caused by Cerebellar Dysfunction

Frontiers in Cellular Neuroscience, 2018
The synchronization of neuronal activity in the sensorimotor cortices is crucial for motor control and learning. This synchrony can be modulated by upstream activity in the cerebello-cortical network.
Elena Laura Georgescu, Elena Laura Georgescu, Ioana Antoaneta Georgescu, Carmen Denise Mihaela Zahiu, Alexandru Răzvan Şteopoaie, Vlad Petru Morozan, Adrian Ştefan Pană, Ana-Maria Zăgrean, Daniela Popa, Daniela Popa   +9 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source