Results 21 to 30 of about 17,410 (180)
Frontiers in Cellular Neuroscience, 2016 Granule cell dispersion (GCD) represents a pathological widening of the granule cell layer (GCL) in the dentate gyrus and it is frequently observed in patients with mesial temporal lobe epilepsy (MTLE).
Catarina Orcinha +20 more
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Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor
Cell Reports, 2016 Synaptic communication between neurons requires the precise localization of neurotransmitter receptors to the correct synapse type. Kainate-type glutamate receptors restrict synaptic localization that is determined by the afferent presynaptic connection.
Christoph Straub +10 more
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Neurobiology of Disease, 1994 A minority subset of cortical neurones exhibit kainate-activated Co2+uptake, a marker for AMPA/kainate receptor gated Ca2+-permeable channels. Consistent with enhanced Ca2+influx through these channels, Co2+-positive neurones are unusually vulnerable to ...
Hong-zhen Yin +3 more
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Frontiers in Psychiatry, 2012 Functional impairment of the orbital and medial prefrontal cortex underlies deficits in executive control that characterize addictive disorders, including alcohol addiction.
Glen eAcosta +3 more
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eLife, 2017 Mesial temporal lobe epilepsy (mTLE) is the most common focal epilepsy in adults and is often refractory to medication. So far, resection of the epileptogenic focus represents the only curative therapy.
Philipp Janz +9 more
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Kainate receptor modulation by NETO2
Nature, 2021 Glutamate-gated kainate receptors (KARs) are ubiquitous in the central nervous system of vertebrates, mediate synaptic transmission on post-synapse, and modulate transmitter release on pre-synapse. In the brain, the trafficking, gating kinetics, and pharmacology of KARs are tightly regulated by Neuropilin and tolloid-like proteins (Netos).
Lingli He +12 more
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Neurobiology of Disease, 2021 Epileptogenesis, the gradual process that leads to epilepsy after brain injury or genetic mutations, is a complex network phenomenon, involving a variety of morphological, biochemical and functional brain alterations. Although risk factors for developing
Lisa Welzel +6 more
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Enhanced integration of newborn neurons after neonatal insults
Frontiers in Neuroscience, 2011 The production and integration of adult-generated neurons in the dentate gyrus is dramatically perturbed by a variety of pathological insults, including repetitive seizures and hypoxia/ischemia.
Phyllis C Pugh +6 more
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Effect of 7-nitroindazoleon superoxide production and MnSOD activity in threat brain following kainate-induced neurotoxicity [PDF]
Archives of Biological Sciences, 2008 We investigated the effect of 7-nitroindazole (7-NI), a selective neuronal nitric oxide synthase inhibitor in vivo, on superoxide concentration as well its influence on mitochondrial MnSOD activity since this activity is associated with the production of
Radenović Lidija
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Oscillatory Cortical Activity in an Animal Model of Dystonia Caused by Cerebellar Dysfunction
Frontiers in Cellular Neuroscience, 2018 The synchronization of neuronal activity in the sensorimotor cortices is crucial for motor control and learning. This synchrony can be modulated by upstream activity in the cerebello-cortical network.
Elena Laura Georgescu +9 more
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