Results 51 to 60 of about 24,046 (180)
Kainate Receptors in Health and Disease [PDF]
, 2013 Our understanding of the molecular properties of kainate receptors and their involvement in synaptic physiology has progressed significantly over the last 30 years. A plethora of studies indicate that kainate receptors are important mediators of the pre-
Marques, Joana M. +2 more
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Cell Reports, 2017 Kainate receptors are members of the glutamate receptor family that regulate synaptic function in the brain. They modulate synaptic transmission and the excitability of neurons; however, their contributions to neural circuits that underlie behavior are ...
Jian Xu +10 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley +1 more source
Synaptic plasticity of kainate receptors
, 2006 Synaptic plasticity of ionotropic glutamate receptors has been extensively studied with a particular focus on the role played by NMDA (N-methyl-D-aspartate) receptors in the induction of synaptic plasticity and the subsequent movement of AMPA (alpha ...
Mellor, JR
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EBioMedicine, 2021 Background: In the setting of drug-resistant epilepsy (DRE), the success of surgery depends on the ability to accurately locate the epileptic foci to be resected or disconnected.
Cong Wang +15 more
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British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley +1 more source
Activation and Desensitization of Hippocampal Kainate Receptors
, 1997 We have used whole-cell recordings and rapid agonist applications to characterize the physiological properties of kainate receptors expressed by rat hippocampal neurons in dissociated cell culture.
Timothy J. Wilding, James E. Huettner
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Molecular Physiology of Kainate Receptors [PDF]
, 2001 28 páginas, 15 figuras, 3 tablas.A decade ago, our understanding of the molecular properties of kainate receptors and their involvement in synaptic physiology was essentially null.
Paternain, Ana V. +7 more
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Frontiers in Cellular Neuroscience, 2018 In mesial temporal lobe epilepsy (mTLE) an initial precipitating injury can trigger aberrant wiring of neuronal circuits causing seizure activity. While circuit reorganization is known to be largely activity-dependent, the interactions between neuronal ...
Philipp Janz +18 more
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Galanin receptor 1 deletion exacerbates hippocampal neuronal loss after systemic kainate administration in mice. [PDF]
PLoS ONE, 2010 Galanin is a neuropeptide with a wide distribution in the central and peripheral nervous systems and whose physiological effects are mediated through three G protein-coupled receptor subtypes, GalR1, GalR2, and GalR3.
P Elyse Schauwecker
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