Results 61 to 70 of about 24,046 (180)

Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

British Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu, Victoria Gizzi, Ugo Pasco, Fatiha Sebih, Yattou Zitouni, Pablo Jimenez, Valérie Rolland, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Thierry Cens, Guillaume Cazals, Pierre Charnet, Janique Guiramand, Catherine Cohen‐Solal, Claudine Ménard, Marie‐Céleste de Jésus Ferreira, Nathalie Chevallier, Sonia Cantel, Michel Vignes, Julien Roussel   +20 more
wiley   +1 more source

Selective agonists and antagonists for kainate receptors.

, 2002
Kainate receptors have only recently been characterized both from the pharmacological and biological point of view. Due to the limited number of truly kainate selective ligands, most of the known agonists and antagonists are generally classified as AMPA ...
M. De Amici, C. De Micheli, P. Conti
core   +1 more source

Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury

The FEBS Journal, EarlyView.
Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester, Owen Leitzel, Samantha Golf, Chelsea M. Phillips, Michael J. Zeitz, Rahul Pandit, Elizabeth Wash, Jenna V. Donohue, Elizabeth A. Istre, James W. Smyth, Samy Lamouille, Stefanie Robel   +11 more
wiley   +1 more source

Synaptic localization of striatal NMDA, quisqualate and kainate receptors [PDF]

, 1989
Striatal binding of labeled glutamate to (NMDA) receptors, -[alpha]-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) to quisqualate receptors and kainate to kainate receptors was examined in rats which had received unilateral decortications or
Young, Anne B., Greenamyre, J. Timothy
core   +1 more source

Inhibition of carbachol-induced inositol phosphate accumulation in the embryonic retina promoted by kainate and veratridine

Brazilian Journal of Medical and Biological Research, 1998
In the present study, we report that low concentrations of the glutamate ionotropic agonist kainate decreased the turnover of [3H]-phosphoinositides ([3H]-InsPs) induced by muscarinic receptors in the chick embryonic retina.
G. Sanches, A.L.M. Ventura
doaj   +1 more source

Ion binding sites and intermediate domain closure induced by D‐serine in the GluD1 ligand‐binding domain

The FEBS Journal, EarlyView.
GluD1 belongs to the ionotropic glutamate receptors and has important functions in the brain and brain diseases. We report the crystal structure of the GluD1 ligand‐binding domain with D‐serine and zinc ions. MD simulations supported promiscuous binding of cations and that chloride ions play a stabilizing role. Pro725 seems to hinder interlobe closure,
Flemming Steen Jørgensen, Emma Grosvald Pedersen, Dilip Narayanan, Karla A. Frydenvang, Jette Sandholm Kastrup   +4 more
wiley   +1 more source

In the developing hippocampus kainate receptors control the release of GABA from mossy fiber terminals via a metabotropic type of action

, 2011
Machine generated contents note: Metabotropic actions of kainate receptors in the control of GABA release -- In the developing hippocampus kainate receptors control the Release of GABA from mossy fiber terminals via a metabotropic type of action ...
Sivakumaran, S., CAIATI MD, Enrico Cherubini, Caiati, Md, Cherubini, Enrico, Sudhir Sivakumaran, SIVAKUMARAN S., Maddalena D. Caiati   +7 more
core   +1 more source

Modulation of Kainate-Induced Excitotoxicity in Rats [PDF]

, 1998
Kainic acid has been used widely as an effective model of excitotoxic neurodegeneration. Using both the intraperitoneal and intrahippocampal routes of injection, we have shown that kainate selectively damages discrete populations of cells in the ...
Jones, Paul A
core   +4 more sources

N‐methyl‐D‐aspartate receptor antagonists for controlling pain in dogs

Journal of Small Animal Practice, EarlyView.
This is a mini review published by the World Small Animal Veterinary Association's Pain Committee. This article provides an assessment of the scientific evidence of N‐methyl‐d‐aspartate receptor antagonists for controlling pain in dogs while identifying current knowledge gaps.
P. W. Kronen, B. D. X. Lascelles, B. P. Monteiro, J. C. Murrell, S. A. Robertson, P. V. Steagall, B. Wright   +6 more
wiley   +1 more source

Responses of cerebral arterioles to kainate.

, 1994
Neurons release nitric oxide in response to glutamate. Glutamate acts via activation of different receptor subtypes, including N-methyl-D-aspartate and kainate receptors.
D D Heistad, F M Faraci, K R Breese
core   +1 more source