Results 61 to 70 of about 22,259 (219)
Neurobiology of Disease, 2022 Background: Epilepsy is one of the most common brain disorder and, despite the possible use of several therapeutic options, many patients continue to have seizures for their entire lifespan and they need new therapeutic approaches.
Elisa Landucci +6 more
doaj +1 more source
Epilepsia Open, EarlyView.Abstract Objective High‐grade astrocytomas, including glioblastomas, are aggressive brain tumors with poor prognosis and a 5‐year survival below 7%. Seizures affect up to 75% of glioma patients, especially in low‐grade tumors but also in high‐grade cases.
Matteo Impellizzeri +7 more
wiley +1 more source
Activation and Desensitization of Hippocampal Kainate Receptors
, 1997 We have used whole-cell recordings and rapid agonist applications to characterize the physiological properties of kainate receptors expressed by rat hippocampal neurons in dissociated cell culture.
Timothy J. Wilding, James E. Huettner
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Frontiers in Cellular Neuroscience, 2018 In mesial temporal lobe epilepsy (mTLE) an initial precipitating injury can trigger aberrant wiring of neuronal circuits causing seizure activity. While circuit reorganization is known to be largely activity-dependent, the interactions between neuronal ...
Philipp Janz +18 more
doaj +1 more source
PROTEOMICS, EarlyView.ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz +6 more
wiley +1 more source
Selective agonists and antagonists for kainate receptors.
, 2002 Kainate receptors have only recently been characterized both from the pharmacological and biological point of view. Due to the limited number of truly kainate selective ligands, most of the known agonists and antagonists are generally classified as AMPA ...
M. De Amici, C. De Micheli, P. Conti
core +1 more source
Galanin receptor 1 deletion exacerbates hippocampal neuronal loss after systemic kainate administration in mice. [PDF]
PLoS ONE, 2010 Galanin is a neuropeptide with a wide distribution in the central and peripheral nervous systems and whose physiological effects are mediated through three G protein-coupled receptor subtypes, GalR1, GalR2, and GalR3.
P Elyse Schauwecker
doaj +1 more source
The FEBS Journal, EarlyView.Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester +11 more
wiley +1 more source
Kainate receptors: on the dark side [PDF]
The Journal of Physiology, 2014 Synaptic glutamate receptors can be divided into metabotropic receptors, an eight-member GPCR family, and ionotropic glutamate receptors, a three-member family of NMDA, kainate, and AMPA tetrameric receptors. The most neglected are the five subunit (GluK1–5) kainate receptors, often either lumped with the AMPA receptors because of pharmacological ...
openaire +2 more sources
Responses of cerebral arterioles to kainate.
, 1994 Neurons release nitric oxide in response to glutamate. Glutamate acts via activation of different receptor subtypes, including N-methyl-D-aspartate and kainate receptors.
D D Heistad, F M Faraci, K R Breese
core +1 more source