Results 81 to 90 of about 22,259 (219)
Kainate receptor function in rodent subcortical visual processing.
, 2007 Glutamate is found throughout the central nervous system and has been shown to be an important excitatory neurotransmitter in the visual system. There are two subdivisions of receptor on which this ubiquitous neurotransmitter acts, metabotropic (mGluR ...
Pothecary, C.A.
core
Kainate promotes alterations in neuronal RNA splicing machinery
, 2011 Kainate, a glutamate analogue, activates kainate and AMPA receptors inducing strong synaptic activation. Systemic kainate application to rodents results in seizures, neurodegeneration, and neuronal remodeling in the brain.
Rohe, M. +13 more
core +1 more source
Augmentation of Ca2+ signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy
Frontiers in Cellular Neuroscience, 2015 Astrocytic endfeet are specialized cell compartments whose important homeostatic roles depend on their enrichment of water and ion channels anchored by the dystrophin associated protein complex.
Karolina eSzokol +19 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 19, 22 May 2026.This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti +27 more
wiley +1 more source
Therapeutic Potential of Kainate Receptors [PDF]
CNS Neuroscience & Therapeutics, 2010 SUMMARYGlutamate receptors are key mediators of brain communication. Among ionotropic glutamate receptors, kainate receptors (KARs) have been least explored and their relevance to pathophysiology is relatively obscure. This is in part due to the relatively low abundance of KARs, the regulatory function in network activity they play, the lack of ...
openaire +2 more sources
Kainate-Induced Cerebrovascular Dilation Is Resistant to Ischemia in Piglets
, 1997 Background and Purpose Cerebral arteriolar dilation to N -methyl- d -aspartate (NMDA) is drastically reduced by anoxic stress.
David W. Busija +2 more
core +1 more source
AMPA Receptor-Mediated Ca2+ Transients in Mouse Olfactory Ensheathing Cells
Frontiers in Cellular Neuroscience, 2019 Ca2+ signaling in glial cells is primarily triggered by metabotropic pathways and the subsequent Ca2+ release from internal Ca2+ stores. However, there is upcoming evidence that various ion channels might also initiate Ca2+ rises in glial cells by Ca2 ...
Antonia Beiersdorfer, Christian Lohr
doaj +1 more source
Advanced Science, Volume 13, Issue 28, 18 May 2026.Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat +6 more
wiley +1 more source
Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate
, 1993 In whole-cell recordings from mammalian CNS neurons, AMPA-preferring glutamate receptors exhibit strong desensitization in response to AMPA, glutamate, and quisqualate, but not to kainate or domoate.
DK Patneau, ML Mayer, L Vyklicky
core +1 more source
Neonatal hypoxic preconditioning involves vascular endothelial growth factor
Neurobiology of Disease, 2007 We studied hypoxic preconditioning (HxP) in the murine developing brain, focusing on the role for vascular endothelial growth factor (VEGF). Newborn mice were used as follows: (1) HxP (or normoxia) then intracerebral (i.c.) NMDA or AMPA-kainate agonist; (
Vincent Laudenbach +8 more
doaj +1 more source