Results 91 to 100 of about 47,334 (259)
Frontiers in Cellular Neuroscience, 2018 In mesial temporal lobe epilepsy (mTLE) an initial precipitating injury can trigger aberrant wiring of neuronal circuits causing seizure activity. While circuit reorganization is known to be largely activity-dependent, the interactions between neuronal ...
Philipp Janz +18 more
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Galanin receptor 1 deletion exacerbates hippocampal neuronal loss after systemic kainate administration in mice. [PDF]
PLoS ONE, 2010 Galanin is a neuropeptide with a wide distribution in the central and peripheral nervous systems and whose physiological effects are mediated through three G protein-coupled receptor subtypes, GalR1, GalR2, and GalR3.
P Elyse Schauwecker
doaj +1 more source
Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]
, 2017 The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
core +3 more sources
Advanced Science, Volume 13, Issue 28, 18 May 2026.Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat +6 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.ABSTRACT Medically intractable temporal lobe epilepsy is associated with potential neuronal and glial damage in key brain structures, including the hippocampus and amygdala. This study aimed to examine apoptosis, caspase expression, and glial activation markers in these regions, and to evaluate their associations with clinical variables.
Fatemeh Alipour +9 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 1998 In the present study, we report that low concentrations of the glutamate ionotropic agonist kainate decreased the turnover of [3H]-phosphoinositides ([3H]-InsPs) induced by muscarinic receptors in the chick embryonic retina.
G. Sanches, A.L.M. Ventura
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A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury. [PDF]
, 2016 The p75 neurotrophin receptor is important in multiple physiological actions including neuronal survival and neurite outgrowth during development, and after central nervous system injury.
Alam, Antoine +20 more
core +1 more source
GLP‐1 at the Metabolic–Cognitive Interface: Reward, Affect, and Memory
Comprehensive Physiology, Volume 16, Issue 2, April 2026.GLP‐1R signaling integrates metabolic state with neural circuits controlling reward, mood, and memory, acting as a metabolic‐cognitive interface. In reward pathways, it suppresses hedonic feeding and drug seeking; in affective circuits, sustained signaling promotes anxiolytic and antidepressant effects; and in the hippocampus, it enhances synaptic ...
Serena X. Gao +5 more
wiley +1 more source
Therapeutic Potential of Kainate Receptors [PDF]
CNS Neuroscience & Therapeutics, 2010 SUMMARYGlutamate receptors are key mediators of brain communication. Among ionotropic glutamate receptors, kainate receptors (KARs) have been least explored and their relevance to pathophysiology is relatively obscure. This is in part due to the relatively low abundance of KARs, the regulatory function in network activity they play, the lack of ...
openaire +2 more sources
Venom and toxins from Argiope lobata: electrophysiological studies
Біологічні студії, 2020 The purpose of this study was to present experimental data on the action of venom and toxins from Argiope lobata spiders on the glutamate channel-receptor complex.
O. M. Klyuchko
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