Results 101 to 110 of about 22,259 (219)
Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains
eLife, 2017 Ion conductivity and the gating characteristics of tetrameric glutamate receptor ion channels are determined by their subunit composition. Competitive homo- and hetero-dimerization of their amino-terminal domains (ATDs) is a key step controlling assembly.
Huaying Zhao +5 more
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Differential Activation of Individual Subunits in Heteromeric Kainate Receptors
, 2002 Neuronal kainate receptors are assembled from subunits with dissimilar specificities for agonists and antagonists. The composite biophysical behavior of heteromeric kainate receptors is determined by intersubunit interactions whose nature is unclear ...
Swanson, Geoffrey T +6 more
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AMPA receptors are the major mediators of excitotoxic death in mature oligodendrocytes
Neurobiology of Disease, 2003 Myelination of axons is important for central nervous system function, but oligodendrocytes, which constitute CNS myelin, are vulnerable to excitotoxic injury and death.
Elizabeth A Leuchtmann +4 more
doaj +1 more source
Kainate Receptor Modulation of GABA Release Involves a Metabotropic Function
, 1998 8 páginas, 7 figuras.The mechanism through which kainate receptors downregulate the release of GABA in the hippocampus is not known. We have found that the action of kainate on the hippocampal inhibitory postsynaptic current (IPSC) is mediated by a ...
Rodríguez-Moreno, Antonio +2 more
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The effects of antidepressant drugs on kainate receptor mRNA levels
, 1991 We have measured the levels of kainate receptor mRNA in rat brains following the injection of antidepressant drugs over a time course up to 32 days. Over this period imipramine and fluvoxamine elicited a rise in kainate receptor mRNA levels to a maximum ...
Buckland, Paul Robert +3 more
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Structure and gating of kainate receptors
Frontiers in PharmacologyIonotropic glutamate receptors (iGluRs) are crucial for fast excitatory neurotransmission in the mammalian central nervous system (CNS). Kainate receptors (KARs), a subclass of iGluRs, are tetrameric, ligand-gated ion channels that play key modulatory roles at both pre- and post-synaptic sites within neuronal circuits and in the regulation of synaptic ...
Gangwar, Shanti P. +4 more
openaire +3 more sources
Basic and Clinical Neuroscience, 2014 Introduction: Temporal lobe epilepsy(TLE) is a long lasting neurological disorder in which patients suffer from spontaneous seizures. New treatments with novel mechanisms of action are needed to help those patients whose seizures are resistant to ...
Tourandokht Baluchnejadmojarad +1 more
doaj
Presynaptic Kainate Receptors in the Hippocampus Slowly Emerging from Obscurity
, 2001 Kainate receptor agonists depress transmitter release at several synapses in the hippocampus. Distinct mechanisms appear to underlie this phenomenon at different synapses.
Kullmann, Dimitri M
core +1 more source
, 2008 It is widely accepted that hippocampal neurogenesis persists throughout life and is altered by acute seizures. Kainate is often used to model temporal lobe epilepsy and hippocampal damage.
Gray, W.P., Pringle, A., Shtaya, A.
core