Results 71 to 80 of about 17,410 (180)

Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange, Erica Zhao, Ellie O'Connell, Olivia Gillham, Amy McTague   +4 more
wiley   +1 more source

(R)-[¹¹C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

BMC Medical Imaging, 2011
Background Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy.
Lammertsma Adriaan A, Huisman Marc C, Windhorst Albert D, Molthoff Carla FM, Luurtsema Gert, Syvänen Stina, Voskuyl Rob A, de Lange Elizabeth C   +7 more
doaj   +1 more source

Kainate Reveals Its Targets [PDF]

Neuron, 1997
Peer ...
openaire   +3 more sources

Ethanolic and aqueous extracts of Lantana camara show antiepileptic and anxiolytic effects by inhibiting the ferroptosis pathway in kainate-treated mice

IBRO Neuroscience Reports
In Cameroon, epilepsy is one of the most common neurological diseases. Available anti-epileptic medication, on the other hand, have been associated with pharmacological toxicity and emotional impairment. The identification of a more efficient replacement
Mabou Symphorien Talom, Kandeda Antoine Kavaye, Bilanda Danielle Claude, Nkengne Steve Melton, Soffo Gildas Moffo, Edzoa Xavier Francois   +5 more
doaj   +1 more source

Structure and gating of kainate receptors

Frontiers in Pharmacology
Ionotropic glutamate receptors (iGluRs) are crucial for fast excitatory neurotransmission in the mammalian central nervous system (CNS). Kainate receptors (KARs), a subclass of iGluRs, are tetrameric, ligand-gated ion channels that play key modulatory roles at both pre- and post-synaptic sites within neuronal circuits and in the regulation of synaptic ...
Gangwar, Shanti P., Yelshanskaya, Maria V., Yen, Laura Y., Newton, Thomas P., Sobolevsky, Alexander I.   +4 more
openaire   +3 more sources

Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains

eLife, 2017
Ion conductivity and the gating characteristics of tetrameric glutamate receptor ion channels are determined by their subunit composition. Competitive homo- and hetero-dimerization of their amino-terminal domains (ATDs) is a key step controlling assembly.
Huaying Zhao, Suvendu Lomash, Sagar Chittori, Carla Glasser, Mark L Mayer, Peter Schuck   +5 more
doaj   +1 more source

AMPA receptors are the major mediators of excitotoxic death in mature oligodendrocytes

Neurobiology of Disease, 2003
Myelination of axons is important for central nervous system function, but oligodendrocytes, which constitute CNS myelin, are vulnerable to excitotoxic injury and death.
Elizabeth A Leuchtmann, Andrea E Ratner, Rattanavijit Vijitruth, Yun Qu, John W McDonald   +4 more
doaj   +1 more source

The Anticonvulsant and Antioxidant Effects of Berberine in Kainate-induced Temporal Lobe Epilepsy in Rats

Basic and Clinical Neuroscience, 2014
Introduction: Temporal lobe epilepsy(TLE) is a long lasting neurological disorder in which patients suffer from spontaneous seizures. New treatments with novel mechanisms of action are needed to help those patients whose seizures are resistant to ...
Tourandokht Baluchnejadmojarad, Mehrdad Roghani   +1 more
doaj  

Possible Role of Akt in Mossy Fiber Sprouting: Akt Activity and CA3 Mossy Fiber Sprouting in a Kainate Model of Epilepsy

Journal of Tropical Life Science
The most prevalent pathological phenomenon observed in patients with epilepsy is hippocampal mossy fiber sprouting (MFS), which is thought to be associated with epileptic progression, such as worsening seizure control, cognitive function, and behavior ...
Machlusil husna, Kusworini Handono, Hidayat Sujuti, Aulanni'am Aulanni'am   +3 more
doaj   +1 more source

Mapping the multi-domain allosteric network for CKAMP44 modulation of AMPA receptors. [PDF]

J Biol Chem
Bharti P, Visal S, Vinnakota R, Kumar J.
europepmc   +1 more source