Results 51 to 60 of about 48,573 (291)

Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG Telemetry

PLoS ONE, 2015
The C57BL/6J mouse as a model of seizure/epilepsy is challenging due to high mortality and huge variability in response to kainate. We have recently demonstrated that repeated administration of a low dose of kainate by intraperitoneal route can induce ...
Sreekanth Puttachary, Shaunik Sharma, K. Tse, Edward Beamer, Abby Sexton, Joseph Crutison, T. Thippeswamy   +6 more
semanticscholar   +1 more source

The spectrum of Ischemia-induced white matter injury varies with age [PDF]

, 2013
Stroke is a neurological condition that targets the whole range of the human population, from the pre-term infant to the elderly and is a major cause of death worldwide (Ingall 2004).
Muscat, Richard, Valentino, Mario, Zammit, Christian   +2 more
core   +1 more source

Kainate receptor channel opening and gating mechanism

Nature
Kainate receptors, a subclass of ionotropic glutamate receptors, are tetrameric ligand-gated ion channels that mediate excitatory neurotransmission1–4.
S. P. Gangwar, M. Yelshanskaya, K. Nadezhdin, L. Yen, Thomas P Newton, Muhammed Aktolun, M. Kurnikova, A. Sobolevsky   +7 more
semanticscholar   +1 more source

Neurotransmitter modulation of extracellular H+ fluxes from isolated retinal horizontal cells of the skate

, 2004
Self-referencing H+-selective microelectrodes were used to measure extracellular H+ fluxes from horizontal cells isolated from the skate retina. A standing H+ flux was detected from quiescent cells, indicating a higher concentration of free hydrogen ions
Birnbaum, Andrea D., Hammar, Katherine, Malchow, Robert Paul, Molina, Anthony J.A, Smith, Peter J.S., Verzi, Michael P., Yamoah, Ebenezer N.   +6 more
core   +2 more sources

Presynaptic adenosine receptor-mediated regulation of diverse thalamocortical short-term plasticity in the mouse whisker pathway [PDF]

, 2016
Short-term synaptic plasticity (STP) sets the sensitivity of a synapse to incoming activity and determines the temporal patterns that it best transmits.
Abbott, Agmon, Ariel, Armbruster, Baden, Bale, Beck, Beierlein, Blackman, Borgdorff, Boudreau, Branco, Branco, Bruno, Buonomano, Calloway, Carvalho, Castro-Alamancos, Castro-Alamancos, Chabrol, Cheetham, Chung, Covic, Crair, Cruikshank, Crunelli, David, Daw, de Jong, Dudek, Dunwiddie, Díaz-Quesada, Díaz-Quesada, Elmslie, Ermolyuk, Fioravante, Fioravante, Fontanez, Fortune, Francisco J. Martini, Gabernet, Gil, Gil, Giovanni Ferrati, Heiss, Hennig, Higley, Jouhanneau, Kandaswamy, Kerr, Kidd, Körber, Leal, Lee, Lee, Lerma, Lupica, McCormick, McCormick, Miguel Maravall, Mochida, Moore, Mulle, Mulle, Müller, Nicoll, Ollerenshaw, Pfister, Pologruto, Porter, Poulet, Reig, Ribrault, Rose, Scanziani, Shen, Sherman, Sippy, Slézia, Stratford, Sun, Sylwestrak, Urbain, Urbano, Viaene, Welzel, Wilent, Wu, Yang, Zhao, Zucker   +90 more
core   +2 more sources

A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury. [PDF]

, 2016
The p75 neurotrophin receptor is important in multiple physiological actions including neuronal survival and neurite outgrowth during development, and after central nervous system injury.
Alam, Antoine, Arnone, Michele, Baroni, Marco, Beattie, Michael S, Bono, Françoise, Bresnahan, Jacqueline C, Canolle, Benoit, Castel, Marie-Noelle, Delbary-Gossart, Sandrine, Delesque-Touchard, Nathalie, Ferguson, Adam R, Ferzaz, Badia, Herbert, Jean-Marc, Laboudie, Patricia, Lamarche, Isabelle, Lee, Sangmi, Lin, Amity, Manley, Geoffrey T, Sacramento, Jeffrey, Salegio, Ernesto A, Savi, Pierre   +20 more
core   +1 more source

GABA-enhanced collective behavior in neuronal axons underlies persistent gamma-frequency oscillations [PDF]

, 2003
Gamma (30–80 Hz) oscillations occur in mammalian electroencephalogram in a manner that indicates cognitive relevance. In vitro models of gamma oscillations demonstrate two forms of oscillation: one occurring transiently and driven by discrete afferent ...
A. Bibbig, Alford, Avoli, Csicsvari, Deuchars, Draguhn, E. H. Buhl, F. E. N. LeBeau, Fisahn, Guly  s, M. A. Whittington, M. O. Cunningham, Miles, Miltner, Morris, Pinault, R. D. Traub, Rodriguez, Schmitz, Semyanov, Stasheff, T. Gloveli, Traub, Traub, Traub, Whittington   +25 more
core   +2 more sources

Kainate Receptors Mediate Signaling in Both Transient and Sustained OFF Bipolar Cell Pathways in Mouse Retina

Journal of Neuroscience, 2014
A fundamental question in sensory neuroscience is how parallel processing is implemented at the level of molecular and circuit mechanisms. In the retina, it has been proposed that distinct OFF cone bipolar cell types generate fast/transient and slow ...
B. Borghuis, L. Looger, S. Tomita, J. Demb   +3 more
semanticscholar   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Effects of glutamate receptor agonists on the P13 auditory evoked potential and startle response in the rat

Frontiers in Neurology, 2011
The P13 potential is the rodent equivalent of the P50 potential, which is an evoked response recorded at the vertex (Vx) 50 msec following an auditory stimulus in humans.
Christen eSimon, Tiffany eWallace-Huitt, Priyenka eThapa, Robert D Skinner, Edgar eGarcia-Rill   +4 more
doaj   +1 more source