Results 101 to 110 of about 5,024,889 (297)

Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease

Advanced Science, Volume 12, Issue 22, June 12, 2025.
This study has unveiled significant new insights into the role of MS4A4A in Alzheimer's disease‐related epilepsy, highlighting its impact on microglial phagocytosis, mitochondrial metabolism, and cytoskeleton, and demonstrating its therapeutic potential in epilepsy management.
Meng Jiang, Qingqing Li, Jianhui Chen, Ruochong Li, Jun Yao, Yong Hu, Haizheng Zhang, Lixin Cai, Maoguo Luo, Yu Sun, Wenwen Zeng   +10 more
wiley   +1 more source

Application of multielectrode array (MEA) chips for studying the neurotoxicity of mixtures [PDF]

, 2011
In vitro neuronal networks are a simplified and accessible model of the central nervous system. Moreover, they exhibit morphological and physiological properties and activity-dependent path-specific synaptic modification similar to the in vivo tissue ...
POLITI MATTEO, RENIERO Fabiano, SCELFO BIBIANA, ZALDIVAR COMENGES Jose'   +3 more
core   +1 more source

An interview with Thomas Foutz, 2025 Epilepsia open prize winner for basic science research

Epilepsia Open, EarlyView.
Merab Kokaia, Piero Perucca
wiley   +1 more source

Exploring biomarkers of neurodegeneration in epilepsy: Critical insights

Epileptic Disorders, Volume 27, Issue 3, Page 341-357, June 2025.
Abstract The advent of biofluid biomarkers for neurodegenerative disorders has precipitated a surge in recent evidence regarding their role in epilepsy. In this literature review, we examine the diagnostic, prognostic, and therapeutic potential of several biomarkers, including amyloid‐beta (Aβ) protein, total (t‐tau), phosphorylated tau (p‐tau) protein,
Rida Farhan, Syeda Amrah Hashmi, Jaideep Kapur, Anelyssa D'Abreu, Vineet Punia, Carol Manning, Vanessa L. Smith, Ifrah Zawar   +7 more
wiley   +1 more source

Protein tyrosine kinase inhibitors modify kainic acid-induced epileptiform activity and mossy fiber sprouting but do not protect against limbic cell death [PDF]

, 2008
Intrahippocampal administration of kainic acid (KA) induces synaptic release of neurotrophins, mainly brain-derived neurotrophic factor, which contributes to the acute neuronal excitation produced by the toxin.
Mello, Luiz Eugenio Araujo de Moraes, Queiroz, Claudio Marcos   +1 more
core   +2 more sources

Polypharmacy with tiagabine, levetiracetam, and perampanel in status epilepticus: Insights from EEG, biochemical, and histopathological studies in rats

Epilepsia Open, Volume 10, Issue 3, Page 669-681, June 2025.
Abstract Objective Status epilepticus (SE) is a condition of neurological emergency, which precipitates various functional and morphological changes in the brain. Due to the risk of drug resistance associated with SE, this study aimed to evaluate a multitargeted approach to treat SE by combining clinically used antiseizure drugs. Methods In this study,
Sana Javaid, Faleh Alqahtani, Abida Parveen, Waseem Ashraf, Zohabia Rehman, Syed Muhammad Muneeb Anjum, Tanveer Ahmad, Imran Imran   +7 more
wiley   +1 more source

Immunomorphologic assessment of changes in functional astroglial proteins in a kainate-induced hippocampal sclerosis model [PDF]

Анналы клинической и экспериментальной неврологии
Introduction. Astrocytes are involved in mediator metabolism, neuroplasticity, energy support of neurons and neuroinflammation, and this determines their pathogenetic role in epilepsy. Aim. This study aimed at evaluating region-specific changes in the
Dmitry N. Voronkov, Anna V. Egorova, Evgenia N. Fedorova, Alla V. Stavrovskaya, Ivan A. Potapov, Anastasiya K. Pavlova, Vladimir S. Sukhorukov   +6 more
doaj   +1 more source

Modulation of the Expression of the GABAA Receptor β1 and β3 Subunits by Pretreatment with Quercetin in the KA Model of Epilepsy in Mice -The Effect of Quercetin on GABAA Receptor Beta Subunits- [PDF]

, 2016
Objectives: Quercetin is a flavonoid and an important dietary constituent of fruits and vegetables. In recent years, several pharmacological activities of quercetin, such as its neuroprotective activity and, more specifically, its anti-convulsant effects
Khodabandehloo, Fatemeh, Moghbelinejad, Sahar, Mohammadi, Ghazaleh, Nassiri-Asl, Marjan, Rashvand, Zahra   +4 more
core   +2 more sources

Cardiac structural and molecular alterations in rodent models of temporal lobe epilepsy

Epilepsia Open, Volume 10, Issue 3, Page 809-821, June 2025.
Abstract Objective Cardiac structural and molecular changes are prevalent in people with chronic epilepsy, possibly contributing to an increased risk of premature mortality. However, understanding of the underlying pathophysiological mechanisms is limited.
Zining Liu, Shobi Sivathamboo, Peravina Thergarajan, Flavia M. Gomes, Idrish Ali, Kim L. Powell, Piero Perucca, Nigel C. Jones, Terence J. O'Brien, Pablo Casillas‐Espinosa   +9 more
wiley   +1 more source

The Effect of Alpha-Lipoic Acid on Learning and Memory Deficit in a Rat Model of Temporal Lobe Epilepsy

Basic and Clinical Neuroscience, 2012
Introduction: Epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures and deficiency in learning and memory.
Tourandokht Baluchnejadmojarad, Mehrdad Roghani, Mitra Kamran, Narges Karimi   +3 more
doaj   +2 more sources