Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics [PDF]
, 2018 Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available ...
Anderton, Ryan S +4 more
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The in vivo proconvulsant effects of corticotropin releasing hormone in the developing rat are independent of ionotropic glutamate receptor activation. [PDF]
, 1998 Corticotropin releasing hormone (CRH) produces age-dependent limbic seizures in the infant rat. Both the phenotype and the neuroanatomic matrix of CRH-induced seizures resemble the seizures induced by the rigid glutamate analogue, kainic acid (KA), and ...
Baram, TZ, Brunson, KL, Schultz, L
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Section of the corpus callosum in kainic acid induced seizures in rats: behavioral, electroencephalographic and neuropathological study. [PDF]
, 1992 Clinical and experimental data suggest that the role of corpus callosum in epilepsy includes synchronization, spread, excitation and inhibition. Section of the corpus callosum (SCC) is known to be a useful therapy in selected types of generalized ...
Baram, TZ +4 more
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Pharmaceutical Biology, 2019 Context: Epilepsy is a common life-threatening neurological disorder that is often drug-resistant and associated with cognitive impairment. The traditional Chinese patent medicine Songling Xuemaikang capsules (SXC) is clinically used for epilepsy therapy
Haiyan Yang +6 more
doaj +1 more source
Topographic plasticity in primary visual cortex is mediated by local corticocortical connections [PDF]
, 2003 The placement of monocular laser lesions in the adult cat retina produces a lesion projection zone (LPZ) in primary visual cortex (V1) in which the majority of neurons have a normally located receptive field (RF) for stimulation of the intact eye and an ...
Calford, M. B. +3 more
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Journal of Neuroscience, 2012 The neurotrophin nerve growth factor (NGF) regulates neuronal growth, differentiation, and survival during development. However, the precursor of NGF, proNGF, is a potent apoptotic ligand for the p75 neurotrophin receptor (p75NTR)–sortilin complex.
A. Le, W. Friedman
semanticscholar +1 more source
Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. [PDF]
, 2007 Elevated brain glutamate with activation of neuronal glutamate receptors accompanies neurological disorders, such as epilepsy and brain trauma. However, the mechanisms by which excitotoxicity triggers neuronal injury are not fully understood.
A. L. SOKKA +8 more
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Status epilepticus results in reversible neuronal injury in infant rat hippocampus: novel use of a marker. [PDF]
, 1994 Despite ready induction of severe limbic status epilepticus by systemic kainic acid (KA) in infant rats, excitotoxic neuronal injury has not been observed. The mechanisms of this resistance of the immature hippocampus to excitotoxicity are unknown.
Baram, TZ, Chang, D
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Excitotoxicity induced by kainic acid provokes glycogen synthase kinase-3 truncation in the hippocampus [PDF]
, 2015 © 2015 Elsevier B.V. In neuronal cultures, glycogen synthase kinase 3(GSK3) is truncated at the N-terminal end by calpain downstream of activated glutamate receptors.
Engel, Tobías +6 more
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The effects of glycemic control on seizures and seizure-induced excitotoxic cell death
BMC Neuroscience, 2012 Background Epilepsy is the most common neurological disorder after stroke, affecting more than 50 million persons worldwide. Metabolic disturbances are often associated with epileptic seizures, but the pathogenesis of this relationship is poorly ...
Schauwecker Paula
doaj +1 more source