Results 181 to 190 of about 15,508 (221)
Some of the next articles are maybe not open access.
Limbic Seizures Induced by Systemically Applied Kainic Acid: How Much Kainic Acid Reaches the Brain?
1986Systemic or intracerebral injection of the neurotoxin kainic acid (KA) in rats induces a limbic seizure and brain damage syndrome, which has been proposed as an experimental animal model for human temporal lobe epilepsy (Nadler, 1981; Ben-Ari, 1985). The electrographic, neurochemical, metabolic and histopathological consequences involve preferentially ...
M L, Berger +3 more
openaire +2 more sources
Kainic Acid Induces Sprouting of Retinal Neurons
Science, 1984The neurotoxin kainic acid caused dose-dependent morphological changes in horizontal cells of the retinas of adult cats and rabbits. High concentrations of kainic acid killed the cells, but when exposed to sublethal doses they contracted their dendritic fields and sent sprouting processes into the inner retina.
L, Peichl, J, Bolz
openaire +2 more sources
Enantioselective Total Synthesis of (−)-α-Kainic Acid
Organic Letters, 2010An enantioselective total synthesis of (-)-alpha-kainic acid is described. Key steps are an Ir-catalyzed allylic amination with a propargylic amine to provide an enyne and a diastereoselective intramolecular Pauson-Khand reaction. Subsequent steps involve a Baeyer-Villiger reaction, reduction of the resulting lactone, and direct Jones oxidation of a ...
Andreas, Farwick, Günter, Helmchen
openaire +2 more sources
Levetiracetam protects against kainic acid-induced toxicity
Life Sciences, 2004We investigated the Levetiracetam (LVT) ability to protect the brain against kainic acid (KA) induced neurotoxicity. Brain injury was induced by intraperitoneal administration of KA (10 mg/kg). Sham brain injury rats were used as controls. Animals were randomized to receive either LVT (50 mg/kg) or its vehicle (1 ml/kg) 30 min. before KA administration.
MARINI, Herbert Ryan +12 more
openaire +3 more sources
Neuronal mapping with kainic acid
Trends in Neurosciences, 1978Abstract Kainic acid, found naturally-occurring in sea-weed, is a substance which is structurally-related to the putative neurotransmitter, glutamate. Kainic acid has now entered the neuroscientists armoury of equipment as a potent and selective neurotoxin which will cause the fast degeneration of neurones with cell bodies in the area of injection ...
openaire +1 more source
Kainic Acid: The Neurotoxic Breakthrough
CRC Critical Reviews in Toxicology, 1982Patrick L. McGeer +2 more
openaire +2 more sources
Biosynthesis of kainic acid uncovered
C&EN Global Enterprise, 2019For centuries, certain red seaweeds were used to treat intestinal worm infections in Japan. And neuroscientists have used the active ingredient from those plants—a molecule known as kainic acid—to ...
openaire +1 more source
Strain differences and kainic acid neurotoxicity
Brain Research, 1979P R, Sanberg, M, Pisa, E G, McGeer
openaire +2 more sources