Results 11 to 20 of about 15,508 (221)

Subthreshold Cannabidiol Potentiates Levetiracetam in the Kainic Acid Model of Temporal Lobe Epilepsy: A Pilot Study [PDF]

Pharmaceuticals
Refractoriness to antiseizure medications is still a major concern in the pharmacotherapy of epilepsy. For this reason, we decided to evaluate the combination of levetiracetam and cannabidiol, administered at a subthreshold dose, to limit the possible ...
Chiara Lucchi, Mattia Marcucci, Kawther Ameen Muhammed Saeed Aledresi, Anna-Maria Costa, Giuseppe Cannazza, Giuseppe Biagini   +5 more
doaj   +2 more sources

The Upregulation of L1CAM by SVHRSP Mitigates Neuron Damage, Spontaneous Seizures, and Cognitive Dysfunction in a Kainic Acid-Induced Rat Model of Epilepsy. [PDF]

Biomolecules
Li Z, Ge B, Li H, Huang C, Ji Y, Schachner M, Yin S, Li S, Zhao J.   +8 more
europepmc   +2 more sources

Cx47 Phosphorylation Exacerbates White Matter Damage and Kainic Acid Induced Epilepsy. [PDF]

CNS Neurosci Ther
Li Y, Lin H, Liu J, Chen J, Shen K, Chen N, Xiang S, Wang D, Xiao N, Li T.   +9 more
europepmc   +2 more sources

Preventive effects of transcranial photobiomodulation on epileptogenesis in a kainic acid-induced rat epilepsy model. [PDF]

Exp Neurol
You J, Fuchs J, Wang M, Hu Q, Tao X, Krolczyk E, Tirumala T, Bragin A, Liu H, Engel J, Li L.   +10 more
europepmc   +3 more sources

Characterization of the intrahippocampal kainic acid model in female mice with a special focus on seizure suppression by antiseizure medications. [PDF]

Exp Neurol
Widmann M, Lieb A, Fogli B, Steck A, Mutti A, Schwarzer C.   +5 more
europepmc   +2 more sources

Compound 4f, a novel brain-penetrant reversible monoacylglycerol inhibitor, ameliorates neuroinflammation, neuronal cell loss, and cognitive impairment in mice with kainic acid-induced neurodegeneration. [PDF]

PLoS One
Arimura N, Maeda C, Aoyama K, Yamaguchi N, Sugiura A, Takahashi Y, Maeda R, Ando T, Kamata M, Matsui H, Tanaka M.   +10 more
europepmc   +2 more sources

EFFECTS OF KAINIC ACID ON GLUTATIONE AND NITRITE IN RAT HIPPOCAMPUS [PDF]

Journal of IMAB, 2011
Epileptiformic activity could result in apoptotic neuronal death, in which oxidative stress could play an important role. In case of decreased antioxidant brain status cellular death could be facilitated.
Nadka I. Boyadjieva, Pavlina Andreeva-Gateva   +1 more
doaj   +1 more source

The role of rosemary extract in degeneration of hippocampal neurons induced by kainic acid in the rat: A behavioral and histochemical approach [PDF]

Journal of Integrative Neuroscience, 2018
Systemic kainic acid administration has been used to induce experimental temporal lobe epilepsy in rats. The aim was to evaluate the neuroprotective effect of rosemary extract (40% Carnosic acid) against kainic acid-induced neurotoxicity in hippocampus ...
Elahe Naderali, Farnaz Nikbakht, Sattar Norouzi Ofogh, Homa Rasoolijazi
doaj   +1 more source

Excitatory amino acids, possible causative agents of nodding syndrome in eastern Africa

Tropical Medicine and Health, 2023
Background Nodding syndrome (NS) is one type of epilepsy and a progressive disease characterized by nodding symptoms with children in sub-Saharan Africa.
Yasushi Miyauchi, Ayaka Shiraishi, Konami Abe, Yasuaki Sato, Kiyoshi Kita   +4 more
doaj   +1 more source

Examining the role of astrogliosis and JNK signaling in post-traumatic epilepsy

Egyptian Journal of Neurosurgery, 2022
Objective Post-traumatic epilepsy is a devastating complication of traumatic brain injury that has no targeted pharmacological therapy. Previous literature has explored the role of the c-Jun N-terminal kinase (JNK) pathway in epilepsy and the creation of
Coulter Small, Abeer Dagra, Melanie Martinez, Eric Williams, Brandon Lucke-Wold   +4 more
doaj   +1 more source