Results 11 to 20 of about 5,024,889 (297)

Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid. [PDF]

Angewandte Chemie, 2019
Kainic acid, the flagship member of the kainoid family of natural neurochemicals, is a widely used neuropharmacological agent that helped unravel the key role of ionotropic glutamate receptors, including the kainate receptor, in the central nervous ...
J. R. Chekan, Shaun M. K. McKinnie, Malia L Moore, Shane G. Poplawski, T. Michael, B. Moore   +5 more
semanticscholar   +5 more sources

Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice. [PDF]

, 2008
Mesial temporal lobe epilepsy is the most common, intractable seizure disorder in adults. It is associated with an asymmetric pattern of hippocampal neuron loss within the endfolium (hilus and CA3) and CA1, with limited pathology in extra-hippocampal ...
Dunleavy, Mark, Engel, Tobias, Hatazaki, Seiji, Henshall, David C, Jimenez-Mateos, Eva, Matsushima, Satoshi, Mouri, Genshin, Paucard, Alexia, Taki, Waro   +8 more
core   +3 more sources

Structure and Syntheses of Kainic Acid

Journal of Synthetic Organic Chemistry, Japan, 1957
Sueo Tatsuoka
openalex   +4 more sources

Efficient synthesis of kainic acid analogues [PDF]

ARKIVOC, 2013
The present paper deals with an improved synthesis of two molecular hybrids of AMPA and KA, compounds CIP-A and CIP-B, and their transformation into CIOP-A and CIOP-B, the corresponding amido derivatives. Exploiting the continuous-flow technology, a significant improvement in the synthesis of the glutamate agonists CIP-A and CIP-B was accomplished, in ...
Lucia Tamborini, Federica Mastronardi, Gregorio Cullia, Roberta Ettari, Carlo De Micheli   +4 more
doaj   +5 more sources

EFFECTS OF KAINIC ACID ON GLUTATIONE AND NITRITE IN RAT HIPPOCAMPUS [PDF]

Journal of IMAB, 2011
Epileptiformic activity could result in apoptotic neuronal death, in which oxidative stress could play an important role. In case of decreased antioxidant brain status cellular death could be facilitated.
Nadka I. Boyadjieva, Pavlina Andreeva-Gateva   +1 more
doaj   +1 more source

The role of rosemary extract in degeneration of hippocampal neurons induced by kainic acid in the rat: A behavioral and histochemical approach [PDF]

Journal of Integrative Neuroscience, 2018
Systemic kainic acid administration has been used to induce experimental temporal lobe epilepsy in rats. The aim was to evaluate the neuroprotective effect of rosemary extract (40% Carnosic acid) against kainic acid-induced neurotoxicity in hippocampus ...
Elahe Naderali, Farnaz Nikbakht, Sattar Norouzi Ofogh, Homa Rasoolijazi
doaj   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

A companion to the preclinical common data elements for rodent models of pediatric acquired epilepsy: A report of the TASK3‐WG1B, Pediatric and Genetic Models Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract Epilepsy syndromes during the early years of life may be attributed to an acquired insult, such as hypoxic–ischemic injury, infection, status epilepticus, or brain trauma. These conditions are frequently modeled in experimental rodents to delineate mechanisms of epileptogenesis and investigate novel therapeutic strategies.
Anna‐Maria Katsarou, Hana Kubova, Stéphane Auvin, Massimo Mantegazza, Melissa Barker‐Haliski, Aristea S. Galanopoulou, Christopher A. Reid, Bridgette D. Semple   +7 more
wiley   +1 more source

Excitatory amino acids, possible causative agents of nodding syndrome in eastern Africa

Tropical Medicine and Health, 2023
Background Nodding syndrome (NS) is one type of epilepsy and a progressive disease characterized by nodding symptoms with children in sub-Saharan Africa.
Yasushi Miyauchi, Ayaka Shiraishi, Konami Abe, Yasuaki Sato, Kiyoshi Kita   +4 more
doaj   +1 more source

A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3‐WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Erwin A. van Vliet, Riikka Immonen, Ofer Prager, Alon Friedman, Jens P. Bankstahl, David K. Wright, Terence J. O'Brien, Heidrun Potschka, Olli Gröhn, Neil G. Harris   +9 more
wiley   +1 more source