Results 21 to 30 of about 15,508 (221)
Bangladesh Journal of Pharmacology, 2023 This study aims to evaluate the anticonvulsant effect of the aqueous extract of Rhus pentaphylla and Cuminum cyminum (300 mg/kg), orally, 45 min before intrahippocampal injection of kainic acid (1 µg/µL).
Khadija Oubella +3 more
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A Practical Synthesis of (−)-Kainic Acid [PDF]
Organic Letters, 2011 A highly practical stereoselective total synthesis of (-)-kainic acid is described. This synthesis features the stereoselective alkylation of an iodolactone intermediate that was efficiently prepared from (+)-carvone and introduction of carboxylic acid by hydrolysis of a nitrile accompanied by epimerizaion.
Satoshi, Takita +2 more
openaire +2 more sources
Laboratory Animal Research, 2020 The kainic acid-induced seizure mouse model is widely used in epilepsy research. In this study, we applied kainic acid to the subcutaneous injections of three different sources of DBA/2 mice to compare and evaluate the seizure response.
Kyung-Ku Kang +10 more
doaj +1 more source
DNA methylation mediates persistent epileptiform activity in vitro and in vivo. [PDF]
PLoS ONE, 2013 Epilepsy is a chronic brain disorder involving recurring seizures often precipitated by an earlier neuronal insult. The mechanisms that link the transient neuronal insult to the lasting state of epilepsy are unknown.
Ziv M Machnes +11 more
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Archives of Epilepsy, 2022 Objective: Aquaporin4 is the main water channel in the brain that is associated with neurological disorders. The role and the expressive changes of aquaporin4 in epilepsy are still limited and controversial. The study aims to evaluate the expression of c-
Emine Taşkıran +7 more
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Effect of Hydroalcoholic Extract of Rosa damascena on Hippocampal Tissue Changes in Temporal Lobe Epilepsy in Rats [PDF]
مجله دانشگاه علوم پزشکی گرگان, 2023 Background and Objective: Temporal lobe epilepsy is characterized by the degeneration of hippocampal neurons and the sprouting of mossy fibers in the dentate area. This study aimed to investigate the impact of the hydroalcoholic extract of Rosa damascene
Reyhanesadat Hashemi-Golpayegani +3 more
doaj
Kainic Acid and MPP+ Induce Upregulation of GLT-1 in Neuroblastoma and Glia Cells
Bezmiâlem Science, 2021 Objective:Glutamate is the major excitatory transmitter in the brain. The excessive glutamate will lead to excitotoxicity. Glutamate transporter-1 (GLT-1) is the major transporter that performs 95% of the glutamate clearance contributing to normal ...
Rabia UYARICI +2 more
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Systemic injection of kainic acid differently affects LTP magnitude depending on its epileptogenic efficiency. [PDF]
PLoS ONE, 2012 Seizures have profound impact on synaptic function and plasticity. While kainic acid is a popular method to induce seizures and to potentially affect synaptic plasticity, it can also produce physiological-like oscillations and trigger some forms of long ...
Luz M Suárez +7 more
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Membranes, 2021 Morphologically and functionally identical to brain synapses, the nerve ending particles synaptosomes are biochemically derived membrane structures responsible for the transmission of neural information.
Virjinia Doltchinkova +2 more
doaj +1 more source