Results 21 to 30 of about 5,024,889 (297)
Epilepsia Open, EarlyView., 2022 Abstract Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events.
Melissa Barker‐Haliski +3 more
wiley +1 more source
Examining the role of astrogliosis and JNK signaling in post-traumatic epilepsy
Egyptian Journal of Neurosurgery, 2022 Objective Post-traumatic epilepsy is a devastating complication of traumatic brain injury that has no targeted pharmacological therapy. Previous literature has explored the role of the c-Jun N-terminal kinase (JNK) pathway in epilepsy and the creation of
Coulter Small +4 more
doaj +1 more source
Laboratory Animal Research, 2020 The kainic acid-induced seizure mouse model is widely used in epilepsy research. In this study, we applied kainic acid to the subcutaneous injections of three different sources of DBA/2 mice to compare and evaluate the seizure response.
Kyung-Ku Kang +10 more
doaj +1 more source
Bangladesh Journal of Pharmacology, 2023 This study aims to evaluate the anticonvulsant effect of the aqueous extract of Rhus pentaphylla and Cuminum cyminum (300 mg/kg), orally, 45 min before intrahippocampal injection of kainic acid (1 µg/µL).
Khadija Oubella +3 more
doaj +1 more source
A Practical Synthesis of (−)-Kainic Acid [PDF]
Organic Letters, 2011 A highly practical stereoselective total synthesis of (-)-kainic acid is described. This synthesis features the stereoselective alkylation of an iodolactone intermediate that was efficiently prepared from (+)-carvone and introduction of carboxylic acid by hydrolysis of a nitrile accompanied by epimerizaion.
Tohru Fukuyama +2 more
openaire +4 more sources
DNA methylation mediates persistent epileptiform activity in vitro and in vivo. [PDF]
PLoS ONE, 2013 Epilepsy is a chronic brain disorder involving recurring seizures often precipitated by an earlier neuronal insult. The mechanisms that link the transient neuronal insult to the lasting state of epilepsy are unknown.
Ziv M Machnes +11 more
doaj +1 more source
Archives of Epilepsy, 2022 Objective: Aquaporin4 is the main water channel in the brain that is associated with neurological disorders. The role and the expressive changes of aquaporin4 in epilepsy are still limited and controversial. The study aims to evaluate the expression of c-
Emine Taşkıran +7 more
doaj +1 more source
Effect of Hydroalcoholic Extract of Rosa damascena on Hippocampal Tissue Changes in Temporal Lobe Epilepsy in Rats [PDF]
مجله دانشگاه علوم پزشکی گرگان, 2023 Background and Objective: Temporal lobe epilepsy is characterized by the degeneration of hippocampal neurons and the sprouting of mossy fibers in the dentate area. This study aimed to investigate the impact of the hydroalcoholic extract of Rosa damascene
Reyhanesadat Hashemi-Golpayegani +3 more
doaj
Kainic Acid and MPP+ Induce Upregulation of GLT-1 in Neuroblastoma and Glia Cells
Bezmiâlem Science, 2021 Objective:Glutamate is the major excitatory transmitter in the brain. The excessive glutamate will lead to excitotoxicity. Glutamate transporter-1 (GLT-1) is the major transporter that performs 95% of the glutamate clearance contributing to normal ...
Rabia UYARICI +2 more
doaj +1 more source
Membranes, 2021 Morphologically and functionally identical to brain synapses, the nerve ending particles synaptosomes are biochemically derived membrane structures responsible for the transmission of neural information.
Virjinia Doltchinkova +2 more
doaj +1 more source