Results 71 to 80 of about 238,231 (259)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Serum iron is associated with the prognosis in sepsis based on a large-scale database

BMC Infectious Diseases
Background Studies on serum iron levels and prognosis in sepsis are limited. We conducted retrospective research based on a public database to investigate the relationships between the serum iron levels and clinical outcomes in sepsis.
Ju Luo, Ning Ding
doaj   +1 more source

Statistical properties of extragalactic sources in the New Extragalactic WMAP Point Source (NEWPS) catalogue

, 2007
We present results on spectral index distributions, number counts, redshift distribution and other general statistical properties of extragalactic point sources in the NEWPS5 sample L\'opez-Caniego et al. (2007).
Bennett, Bertin, Cantor, Cleary, Condon, Condon, D. Herranz, Danese, De Zotti, De Zotti, Eddington, Ekers, F. Argüeso, G. De Zotti, González-Nuevo, Gregory, Griffith, Griffith, Herranz, Hinshaw, Hogg, J. González-Nuevo, J. L. Sanz, Kaplan, L. Toffolatti, Lucy, López-Caniego, López-Caniego, M. López-Caniego, M. Massardi, Massardi, Mauch, Planck Collaboration, Ricci, Ricci, Sadler, Taylor, Toffolatti, Toffolatti, Waldram, Waldram, Wright, Wright   +42 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

An Online Updating Approach for Testing the Proportional Hazards Assumption with Streams of Big Survival Data

, 2018
The Cox model, which remains as the first choice in analyzing time-to-event data even for large datasets, relies on the proportional hazards assumption. When the data size exceeds the computer memory, the standard statistics for testing the proportional ...
Schifano, Elizabeth D., Wang, HaiYing, Xue, Yishu, Yan, Jun   +3 more
core   +1 more source

Cost-effectiveness analysis in R using a multi-state modelling survival analysis framework: a tutorial [PDF]

, 2016
This tutorial provides a step-by-step guide to performing cost-effectiveness analysis using a multi-state modelling approach. Alongside the tutorial we provide easy-to-use functions in the statistics package R.
Briggs, Andrew H., Lewsey, James D., Mackay, Daniel F., Williams, Claire   +3 more
core   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Prognostic Significance of Lactate Dehydrogenase in Patients Undergoing Surgical Resection for Laryngeal Squamous Cell Carcinoma

Cancer Control, 2020
The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in patients undergoing surgical resection for laryngeal squamous cell carcinoma (LSCC). A total of 640 resected LSCC patients were included.
Erliang Guo MD, Lunhua Guo MD, Changming An MD, Cong Zhang MD, Kaibin Song MD, Guohui Wang MD, Chunbin Duan MD, Xiwei Zhang MD, Xianguang Yang MD, Zhennan Yuan MD, Junnan Guo MD, Ji Sun MD, Hongxue Meng MD, Rui Chang MD, Xiaomei Li MD, Cheng Xiu MD, Xionghui Mao MD, Susheng Miao MD   +17 more
doaj   +1 more source

Application of a simple nonparametric conditional quantile function estimator in unemployment duration analysis [PDF]

We consider an extension of conventional univariate Kaplan-Meier type estimators for the hazard rate and the survivor function to multivariate censored data with a censored random regressor.
Wichert, Laura, Wilke, Ralf A.
core  

The Unintended Consequences of Flexicurity : The Health Consequences of Flexible Employment [PDF]

, 2015
Publisher ...
Bender, Keith Allen, Theodossiou, Ioannis   +1 more
core