Results 71 to 80 of about 2,137,840 (268)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Long-term incidence and outcomes of skin cancer in kidney transplant recipients under reduced-dose immunosuppression: A retrospective cohort study

Transplantation Reports
Introduction: Skin cancer is the most common malignancy in kidney transplant recipients (KTRs), with a higher aggressiveness due to prolonged immunosuppression. Optimizing immunosuppressive regimens may reduce risk while preserving graft function.
Gabriela Orozco, Julia Andrea Gómez-Montero, Isabella Monsalve, Santiago Cabas, Andrea Garcia-Lopez, Fernando Giron-Luque   +5 more
doaj   +1 more source

Comparison of nonparametric estimators versus parametric for reliability function

Ingeniería Investigación y Desarrollo, 2015
One of the main objectives of the area of realiability is to estimate the function of reliability, where traditionally are used non parametric estimators, being more efficient in sample of big sizes.
Javier Ramírez-Montoya
doaj   +1 more source

Kaplan-Meier seroprotection diagram.

, 2021
Kaplan-Meier seroprotection diagram.
Samsuridjal Djauzi (3840121), Alisa Nurul Muthia (11846344), Cissy Kartasasmita (5094791), Nuning Masjkuri (11846338), Mardiati Nadjib (4033538), Ummu Habibah (11846350), Rini Mulia Sari (6331079), Sukamto Koesnoe (11846335), Mondastri Korib (11846341), Novilia Sjafri Bachtiar (6331082), Julitasari Sundoro (10035770), Saskia Aziza Nursyirwan (11846353), Kristoforus Hendra Djaya (11846356), Asri Adisasmita (10924813), Virly Nanda Muzellina (11846347)   +14 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Association between homocysteine levels and hyperlipidemia prevalence as well as all-cause mortality of hyperlipidemia patients in the US population: results from NHANES database

Frontiers in Cardiovascular Medicine
ObjectiveSeveral studies have investigated the correlation between blood lipids and homocysteine, but no clear conclusions have been defined yet. Therefore, we utilized data from National Health and Nutrition Examination Survey (NHANES) to explore the ...
Jia Wei, Qiang Yang, Xiaofang Wang, Xin He, Wenjing Zhu, Lin Lin, Chang Liu, Canzhan Zhu, Mingjuan Zhang   +8 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Kaplan-Meier estimate of probability of attending for first episode of unscheduled asthma care by days since intervention

, 2016
Kaplan-Meier estimate of probability of attending for first episode of unscheduled asthma care by days since ...
Geoff Packe (3604976), Kamrul Islam (430894), Gene Feder (80748), Chris Griffiths (119288), Aklak Choudhury (3605003), Jean Ramsay (3604994), Ratna Sohanpal (3604979), Stephanie Taylor (95318), Stephen Bremner (119242), Debi-Lee Vidal (3604973), Duncan Trathen (3604991), Viv Cook (3604982), Sandra Eldridge (80747), Anna Eleri Livingstone (3604988), Gillian Foster (3605006), Neil Barnes (3604997), Elizabeth Bayliss (3466778), Philip Moss (3604985), Carolyn Dawson (3605000)   +18 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Kaplan-Meier estimate of percentage of recurrent stroke.

, 2014
Kaplan-Meier estimate of percentage of recurrent stroke.
Yuen-Kwun Wong (521825), Kay-Cheong Teo (521826), Richard Shek-Kwan Chang (521827), Sonny Fong-Kwong Hon (521828), Shu-Leong Ho (101984), Raymond Tak-Fai Cheung (521829), Koon-Ho Chan (291734), Hung-Fat Tse (351982), Kui-Kai Lau (521824), Leonard Sheung-Wai Li (521830), Chung-Wah Siu (351983)   +10 more
core   +1 more source