Results 31 to 40 of about 12,565 (224)

Restricted Kaposi’s Sarcoma (KS) Herpesvirus Transcription in KS Lesions from Patients on Successful Antiretroviral Therapy

mBio, 2011
Kaposi’s sarcoma (KS) is caused by Kaposi’s sarcoma-associated herpesvirus (KSHV; human herpesvirus 8). KS is an AIDS-defining cancer, and it is changing in the post-antiretroviral therapy (post-ART) era.
Dirk P. Dittmer
doaj   +1 more source

Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections

Nature Communications, 2020
Disease prognosis after infection with Kaposi’s sarcoma-associated herpesvirus and Epstein-Barr Virus is highly variable. Here the authors carry out epidemiological and genetic analysis of a Ugandan cohort and suggest complex interactions may influence ...
Neneh Sallah, Wendell Miley, Nazzarena Labo, Tommy Carstensen, Segun Fatumo, Deepti Gurdasani, Martin O. Pollard, Alexander T. Dilthey, Alexander J. Mentzer, Vickie Marshall, Elena M. Cornejo Castro, Cristina Pomilla, Elizabeth H. Young, Gershim Asiki, Martin L. Hibberd, Manjinder Sandhu, Paul Kellam, Robert Newton, Denise Whitby, Inês Barroso   +19 more
doaj   +1 more source

Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues. [PDF]

PLoS Pathogens, 2017
Kaposi's sarcoma-associated herpesvirus (KSHV) is etiologically related to Kaposi's sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD).
Rui Sun, Xiaohua Tan, Xing Wang, Xiaodong Wang, Lei Yang, Erle S Robertson, Ke Lan   +6 more
doaj   +1 more source

NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target. [PDF]

, 2015
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL), which are aggressive malignancies associated with immunocompromised patients.
A Sarikas, A Yaron, Adrian Whitehouse, AF Kisselev, AS Turnell, B Romani, Belinda Baquero-Pérez, BR Jackson, BR Jackson, Brian R. Jackson, C Grossmann, C Simonelli, CC Rossetto, David J. Hughes, DE de Oliveira, DF Lee, DJ Goodwin, DJ Stanley, DP Dittmer, E Boulanger, EA Mesri, EJ Bennett, F Gould, G Jubelin, G Rabut, H Karttunen, H Matta, H Nakamura, HC Jha, HJ Brown, J Hannah, J Jin, Jennifer J. Wood, JM O'Dowd, JR Boyne, KA Sarosiek, Klaus Früh, KR Alkharsah, KT Hall, L La Ferla, M Karin, M Pearce, MA Milhollen, MA Milhollen, O Vieira J, P Wimmer, QL Cai, R Sun, RD Everett, S Bhatt, S Gantt, S Gastaldello, SP Jackson, T Ma, T Nakagawa, TA Soucy, TA Soucy, V Majerciak, W Bu, W Chen, X Lei, X Yu, Y Izumiya, Y Wang, Y Wang   +64 more
core   +3 more sources

Epigenetic diversity of Kaposi’s sarcoma–associated herpesvirus [PDF]

Nucleic Acids Research, 2013
Spontaneous lytic reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) occurs at a low rate in latently infected cells in disease and culture. This suggests imperfect epigenetic maintenance of viral transcription programs, perhaps due to variability in chromatin structure at specific loci across the population of KSHV episomal genomes.
Darst, Russell P., Haecker, Irina, Pardo, Carolina E., Renne, Rolf, Kladde, Michael P.   +4 more
openaire   +2 more sources

Modulation of immune system by Kaposi’s sarcoma-associated herpesvirus:Lessons from viral evasion strategies

Frontiers in Microbiology, 2012
Kaposi’s sarcoma-associated herpesvirus (KSHV), a member of the herpesvirus family, has evolved to establish a long-term, latent infection of cells such that while they carry the viral genome gene expression is highly restricted.
Hye-Ra eLee, Kevin eBrulois, LaiYee eWong, Jae U. eJung   +3 more
doaj   +1 more source

Productively infected murine Kaposi's sarcoma-like tumors define new animal models for studying and targeting KSHV oncogenesis and replication. [PDF]

PLoS ONE, 2014
Kaposi's sarcoma (KS) is an AIDS-defining cancer caused by the KS-associated herpesvirus (KSHV). KS tumors are composed of KSHV-infected spindle cells of vascular origin with aberrant neovascularization and erythrocyte extravasation. KSHV genes expressed
Brittany M Ashlock, Qi Ma, Biju Issac, Enrique A Mesri   +3 more
doaj   +1 more source

Constitutive activation of T cells by γ2-herpesviral GPCR through the interaction with cellular CXCR4 [PDF]

, 2017
Members of the herpesviral family use multiple strategies to hijack infected host cells and exploit cellular signaling for their pathogenesis and latent infection.
Aigerim, A, Cha, J.S, Cho, H.-S, Cho, N.-H., Choi, M.-S, Han, S.K, Kim, H, Kim, K, Kim, S, Kim, Y, Kwon, E.-K, Lee, J.-W, Min, C.-K, Nam, H.-J, Schmidt, S   +14 more
core   +1 more source

Regulation of the retinoblastoma proteins by the human herpesviruses [PDF]

, 2009
Viruses are obligate intracellular parasites that alter the environment of infected cells in order to replicate more efficiently. One way viruses achieve this is by modulating cell cycle progression.
Kalejta Robert F, Hume Adam J
core   +2 more sources

The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus

Advances in Virology, 2010
Kaposi's sarcoma-associated herpesvirus (KSHV) is the aetiological agent of Kaposi's sarcoma (KS), the most frequently arising malignancy in individuals with untreated HIV/AIDS.
Rebecca C. Robey, Salvinia Mletzko, Frances M. Gotch   +2 more
doaj   +1 more source