Results 81 to 90 of about 8,714,646 (173)

The HIV Protease Inhibitor Nelfinavir Inhibits Kaposi’s Sarcoma-Associated Herpesvirus Replication In Vitro

, 2011
Kaposi’s sarcoma (KS) is the most common HIV-associated cancer worldwide and is associated with high levels of morbidity and mortality in some regions.
Eliora Gachelet, Michael Lagunoff, Adam P. Geballe, Lawrence Corey, Jacquelyn Carlsson, Minako Ikoma, Matthew Gray, Corey Casper, Jeffrey Vieira, Soren Gantt   +9 more
core   +1 more source

Clinical and Diagnostic Insights into Penile Angiolymphoid Hyperplasia with Eosinophilia Based on a Case and Analysis of Previous Literature

Skin Research and Technology, Volume 32, Issue 10, October 2026.
ABSTRACT Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign vascular proliferation of unknown origin. It typically occurs in the head and neck region, but can occasionally manifest in unusual locations, such as the penis. Herein, we report a case of ALHE in a 46‐year‐old HIV‐infected male presenting with multiple pruritic whitish ...
Rievanda Ayu Natasya, Retno Hesty Maharani, Eva Krishna Sutedja, Hermin Aminah Usman, Hanifah Nurul Huda, Pati Aji Achdiat   +5 more
wiley   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Kaposi’s Sarcoma-Associated Herpesvirus and Host Interaction by the Complement System

, 2020
Kaposi’s sarcoma-associated herpesvirus (KSHV) modulates the immune response to allow the virus to establish persistent infection in the host and facilitate the development of KSHV-associated cancer.
Myung-Shin Lee, Seung-Min Yoo
core   +1 more source

Mitochondrial protein, TBRG4, modulates KSHV and EBV reactivation from latency

PLoS Pathogens, 2022
Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr (EBV) are gammaherpesviruses associated with multiple human malignancies. KSHV is the etiological agent of Kaposi’s Sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s ...
Huirong Zhang, Jason P. Wong, Guoxin Ni, Patricio Cano, Dirk P. Dittmer, Blossom Damania   +5 more
doaj  

Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus

Pathogens, 2012
As obligate intracellular pathogens, viruses depend on the host cell machinery to complete their life cycle. Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus causally linked to the development of Kaposi’s sarcoma and several other ...
Wei Zhang, Shou-Jiang Gao
doaj   +1 more source

Kaposi’s Sarcoma Herpesvirus Genome Persistence [PDF]

, 2016
Kaposi’s sarcoma-associated herpesvirus (KSHV) has an etiologic role in Kaposi’s sarcoma, primary effusion lymphoma and multicentric Castleman’s disease. These diseases are most common in immunocompromised individuals, especially those with AIDS. Similar
Kaye, Kenneth, Shijun Li, Kenneth M. Kaye, Franceline Juillard, Li, Shijun, Min Tan, Juillard, Franceline, Tan, Min   +7 more
core   +1 more source

Epidemiology and Transmission of Kaposi’s Sarcoma-Associated Herpesvirus

Viruses, 2014
This review summarizes the current knowledge pertaining to Kaposi sarcoma-associated herpesvirus (KSHV) epidemiology and transmission. Since the identification of KSHV twenty years ago, it is now known to be associated with Kaposi’s sarcoma (KS ...
Veenu Minhas, Charles Wood
doaj   +1 more source

The Kaposi’s Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Contains an Immunoreceptor Tyrosine-Based Inhibitory Motif That Activates Shp2

, 2010
The Kaposi’s sarcoma-associated herpesvirus (KSHV) G protein-coupled receptor (vGPCR) is a constitu-tively active, highly angiogenic homologue of the interleukin-8 (IL-8) receptors that signals in part via the cytoplasmic protein tyrosine phosphatase ...
Liwei Chen, Nicola Philpott, Jie Wu, Thomas Bakken, Mark Cannon, Christopher Pennell   +5 more
core   +1 more source

Suppressing Kaposi’s Sarcoma-Associated Herpesvirus Lytic Gene Expression and Replication by RNase P Ribozyme

, 2023
Kaposi’s sarcoma, an AIDS-defining illness, is caused by Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic virus. In this study, we engineered ribozymes derived from ribonuclease P (RNase P) catalytic RNA with targeting against the mRNA ...
Yujun Liu, Yuan-Chuan Chen, Fenyong Liu, Bin Yan   +3 more
core   +1 more source