Results 61 to 70 of about 1,120 (144)
Targeted Therapies for Slow‐Flow Vascular Malformations
Australasian Journal of Dermatology, Volume 66, Issue 3, Page 142-151, May 2025.ABSTRACT Advances in genetic sequencing technologies have enabled the identification of key activating somatic variants in cellular signalling pathways involved in the pathogenesis of vascular malformations. Given that these genetic variants are also implicated in the pathogenesis of several cancers, the repurposing of targeted therapies developed in ...
Grace X. Li +2 more
wiley +1 more source
Lymphangiomatosis in a 14-year-old female presenting with chylothorax and multiple cystic lesions
, 2018 Lymphangiomatosis is a rare congenital disease; diagnosis is made in the first 2 decades and affects almost all body parts. Imaging findings play an important role in the diagnosis.
Veronica Prada +4 more
core +1 more source
, 2019 Table S1. Clinical Characteristics of patients with KLA or KHE. (DOCX 25 kb)
Ji, Yi +4 more
openaire +1 more source
Pediatric Blood &Cancer, Volume 71, Issue 7, July 2024.Abstract Background Angiopoietin‐2 (Ang‐2) is increased in the blood of patients with kaposiform lymphangiomatosis (KLA) and kaposiform hemangioendothelioma (KHE). While the genetic causes of KHE are not clear, a somatic activating NRASQ61R mutation has been found in the lesions of KLA patients.
Patricia Pastura +7 more
wiley +1 more source
Diffuse Pulmonary Lymphangiomatosis [PDF]
, 2013 Diffuse pulmonary lymphangiomatosis (DPL) is a rare disease characterized by infiltration of the lung, pleura and mediastinum with thin-walled lymphangiomas.
Kunal C Kadakia +3 more
core +1 more source
How we use angiopoietin‐2 in the diagnosis and management of vascular anomalies
Pediatric Blood &Cancer, Volume 71, Issue 5, May 2024.Abstract The diagnosis of vascular anomalies remains challenging due to significant clinical heterogeneity and uncertain etiology. Evaluation using biopsy and/or genetic testing for somatic variants is invasive, expensive, and prone to sampling error. There is great need for noninvasive and easily measured blood laboratory biomarkers that can aid not ...
Elissa R. Engel +2 more
wiley +1 more source
Lymphangiomatosis – A Rare Disease in Pediatrics
, 2015 Lymphangiomatosis is rare in both adults and children. We present an 11 year old boy with right chylothorax. The formation of chylothorax was a result of diffuse lymphangioma in the mediastinum spreading to the pleura.
Tuan DM +5 more
core +1 more source
Video_1_Laparoscopy for evaluating mesenteric lymphangiomatosis: A case report.mov
, 2022 BackgroundLymphangiomatosis is an extremely rare disease with potential soft tissue, bone, and spleen involvement, which can be characterized by lymphangioma. Only a few cases of colon and mesenteric lymphangiomatosis have been reported. We report a case
Xishan Wang (282956) +2 more
core +1 more source
Kaposiform lymphangiomatosis with Kasabach–Merritt phenomenon
Pediatric Hematology/Oncology and ImmunopathologyKaposiform lymphangiomatosis (KLA) is an aggressive lymphatic anomaly associated with bone involvement, serositis occurring at various sites, the development of Kasabach–Merritt phenomenon, and frequent infectious complications. The International Society for the Study of Vascular Anomalies classifies KLA as a subtype of generalized lymphatic anomaly.
L. A. Khachatryan +5 more
openaire +1 more source
Complex lymphatic anomalies: Challenging diagnostic considerations
Clinical Case Reports, Volume 12, Issue 1, January 2024.This is a CT scan demonstrating an infiltrative mass that is invading the anterior mediastinum. This image is representative of a complex lymphatic anomaly, which can be difficult to diagnose and can have potentially life‐threatening complications with biopsies.
Venkatraman Kothandaraman +2 more
wiley +1 more source