Results 201 to 210 of about 118,679 (261)

Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases

Advanced Science, EarlyView.
ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti, Libor Vítek, Silvia Gazzin, Claudio Tiribelli   +3 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Detection of social frailty in older adults: validation and reliability of the Makizako Social Frailty Index for Turkish older adults, a cross-sectional study. [PDF]

BMC Geriatr
Atbas C, Sayin H, Karaduman D, Sahiner Z, Hafizoglu M, Pehlivan M, Balci C, Dogu BB, Halil M, Cankurtaran M.   +9 more
europepmc   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Isolated Pulmonary Light Chain Deposition Disease. [PDF]

Eur J Case Rep Intern Med
Pendyala M, Bandarupalli P, Kaur P, Khatri V, Khatri K.   +4 more
europepmc   +1 more source

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, EarlyView.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source

Spatiotemporal analysis of plague risk in Tibet: Multi-source data-driven ensemble model development and validation. [PDF]

One Health
Guo L, Zhang X, Lin Z, Cui Z, Li C, Wu S.   +5 more
europepmc   +1 more source

Classification of angioedema types using decision tree modeling. [PDF]

Front Immunol
Aulenbacher F, Gutsche A, Farkas H, Kőhalmi KV, Kocatürk E, Aygören-Pürsün E, Martin L, Longhurst H, Staubach P, Zanichelli A, Aberer W, Bygum A, van den Elzen M, Buttgereit T, Magerl M.   +14 more
europepmc   +1 more source

Prognostic value of kappa free light chain index in patients with primary progressive multiple sclerosis. [PDF]

Front Immunol
Schmidauer M, Berek K, Auer M, Bsteh G, Cavalla P, Di Pauli F, Di Filippo M, Deisenhammer F, Emeršič A, Föttinger F, Gaetani L, Hassler M, Krajnc N, Milosavljevic D, Ponleitner M, Petersen T, Presslauer S, Rosenstein I, Rot U, Tørring CW, Vecchio D, Vercellino M, Zrzavy T, Zinganell A, Walde J, Hegen H.   +25 more
europepmc   +1 more source