Results 91 to 100 of about 71,106 (270)

Alcohol-induced plasticity in the dynorphin / kappa-opioid receptor system

Frontiers in Molecular Neuroscience, 2012
Alcoholism is a chronic relapsing disorder characterized by continued alcohol use despite numerous adverse consequences. Alcohol has been shown to interact with numerous neurotransmitter systems to exert its pharmacological effects. The endogenous opioid
Sunil eSirohi, Georgy eBakalkin, Brendan M. Walker   +2 more
doaj   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Central nicotine induces browning through hypothalamic κ opioid receptor

Nature Communications, 2019
Nicotine reduces food intake and increases energy expenditure in brown adipose tissue. Here the authors show that nicotine also induces white adipose tissue browning via central kappa opioid receptor action.
Patricia Seoane-Collazo, Laura Liñares-Pose, Eva Rial-Pensado, Amparo Romero-Picó, José María Moreno-Navarrete, Noelia Martínez-Sánchez, Pablo Garrido-Gil, Ramón Iglesias-Rey, Donald A. Morgan, Naoki Tomasini, Samuel Andrew Malone, Ana Senra, Cintia Folgueira, Gema Medina-Gomez, Tomás Sobrino, José L. Labandeira-García, Rubén Nogueiras, Ana I. Domingos, José-Manuel Fernández-Real, Kamal Rahmouni, Carlos Diéguez, Miguel López   +21 more
doaj   +1 more source

Effectiveness of Psychosocial Interventions for Adults With Substance Use Disorder That Have a Co‐Occurring Common Mental Health Disorder: An Umbrella Review

Drug and Alcohol Review, Volume 45, Issue 1, January 2026.
ABSTRACT Issues People with substance use disorders can have co‐occurring mental disorders. Approach An umbrella review was conducted to identify evidence of the effectiveness of psychosocial interventions for adults (aged 18+) with substance use disorders and co‐occurring common mental health disorders.
Emma L. Simpson, Munira Essat, Ruth Wong, Sarah Stacey, Edward Day   +4 more
wiley   +1 more source

Diuretic Activity of a Novel Peripherally-Restricted Orally-Active Kappa Opioid Receptor Agonist

Medical Sciences, 2019
Kappa-opioid agonists (KOAs) enhance cardiac performance, as well as reduce infarct size and prevent deleterious cardiac remodeling following myocardial infarction.
Tyler C. Beck, Matthew A. Hapstack, Gautam S. Ghatnekar, Thomas A. Dix   +3 more
doaj   +1 more source

Effect of Dezocine and Dexmedetomidine as Adjuvants in Ropivacaine for Incision Subcutaneous Infiltration Anesthesia on Incision Healing in Diabetic Rats

Brain and Behavior, Volume 15, Issue 12, December 2025.
The adjunctive use of dezocine and dexmedetomidine with ropivacaine in incisional subcutaneous infiltration anesthesia may contribute to improved incision healing in diabetic rats. ABSTRACT Introduction Surgery can induce insulin resistance (IR) in diabetic patients, and severe IR compromises the body's ability to combat infection and shock, impairs ...
Lang Yu, Bin Gao, Lingling Sun, Jing Mu, Piaopiao Zhang, Qin Zhang, Huanzhong He, He Liu   +7 more
wiley   +1 more source

A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists

Frontiers in Pharmacology, 2019
Between 2000 and 2005 several studies revealed that morphine is more potent and exhibits fewer side effects in beta-arrestin 2 knockout mice. These findings spurred efforts to develop opioids that signal primarily via G protein activation and do not, or ...
Kendall L. Mores, Benjamin R. Cummins, Robert J. Cassell, Robert J. Cassell, Richard M. van Rijn, Richard M. van Rijn, Richard M. van Rijn   +6 more
doaj   +1 more source

Structure of the human kappa opioid receptor in complex with JDTic

Nature, 2012
Opioid receptors mediate the actions of endogenous and exogenous opioids on many physiological processes, including the regulation of pain, respiratory drive, mood, and—in the case of κ-opioid receptor (κ-OR)—dysphoria and psychotomimesis. Here we report
Huixian Wu, Daniel Wacker, V. Katritch, Mauro Mileni, Gye Won, Han, Eyal Vardy, Wei Liu, A. Thompson, Xi-Ping Huang, F. Carroll, S. Mascarella, R. Westkaemper, P. Mosier, B. Roth, V. Cherezov, R. Stevens   +16 more
semanticscholar   +1 more source

UPLC–ESI–QToF–MS Profile of Hydroalcoholic Extract of Persea cordata (Meisn.) and its Antioedematogenic and Antinociceptive Effects in Mice

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
Hydroalcoholic crude extract of Persea cordata showed in its composition, the presence of lignans based on LCESIMS data. This crude extract displayed anti‐oedematogenic and antinociceptive activities in vivo. Abstract This study aimed to establish the chemical profile and evaluate the anti‐oedematogenic and analgesic activities of the hydroalcoholic ...
Valfredo Schlemper, Daniela Hemsing, Julia Elisabett K. Bolsonello, Susana R. de Mello Schlemper, Tiago Tizziani, Lutuima A. Capangue Neto, Louis P. Sandjo   +6 more
wiley   +1 more source

Worldwide Research Trends on Substance Use Disorder‐Related Inflammatory Imbalances: A Bibliometric Analysis

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
A bibliometric analysis of worldwide research trends on “substance use disorder‐related inflammation”. “Neuroinflammation” is identified as a key research hotspot. The findings provide a data‐driven overview of the evolving landscape in this field. ABSTRACT Background Substance use disorder (SUD) is a complex, chronic, and relapsing encephalopathy ...
Shirui Cao, Longtao Yang, Ruixin Wang, Jun Liu   +3 more
wiley   +1 more source