Results 101 to 110 of about 1,463,708 (228)

The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat

open access: yes, 2013
Placebo analgesia is one of the most robust and best-studied placebo effects. Recent researches suggest that placebo analgesia activated the m-opioid receptor signalling in the human brain.
Zhang, Wen-Cai   +3 more
core   +1 more source

A Systematic Review of Hypnosis for Clinical Pain Relief

open access: yesEuropean Journal of Pain, Volume 30, Issue 8, September 2026.
ABSTRACT Background Previous reviews report moderate reductions in clinical pain with hypnotic suggestion but provide only partial views by comparing hypnosis with inactive controls alone or including few studies or mixed control groups. This review comprehensively evaluated the efficacy of hypnosis in reducing clinical pain intensity compared with non‐
Titus H. Yim, Stuart W. G. Derbyshire
wiley   +1 more source

Comportamento de coçar e nocicepção evidenciados após a aplicação facial de endotelina-1: um novo teste, uma nova oportunidade farmacológica [PDF]

open access: yes, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011O presente trabalho reproduziu o modelo experimental descrito por Shimada e Lamotte, (2008), e o
Gomes, Lenyta Oliveira
core  

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

open access: yesFood Biomacromolecules, Volume 3, Issue 3, Page 444-465, September 2026.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Methods of Assessing Postoperative Pain in Infants (0–12 Months): A Scoping Review

open access: yesPaediatric and Neonatal Pain, Volume 8, Issue 3, September 2026.
ABSTRACT Infants undergoing surgery experience postoperative pain beyond acute short‐lasting procedural pain and have variable analgesic needs. Assessing pain in this nonverbal population presents challenges for clinicians and parents. Given the short‐ and long‐term effects of pain and its treatment, timely and accurate assessment of pain is vital. The
Jeewan Jyoti   +5 more
wiley   +1 more source

Kappa Opioid Receptor Expression by Macrophages

open access: yes
The endogenous opioid system includes three primary opioid receptors: the mu, delta, and kappa opioid receptors. Each is a G-protein-coupled receptor expressed on the exterior membrane of diverse cell types, with neuronal cells having been the most ...
Reed, Brian
core   +1 more source

Patient‐reported outcomes for monitoring substance use treatment: A systematic review of single‐item measures

open access: yesAddiction, Volume 121, Issue 9, Page 2292-2316, September 2026.
Abstract Background and aims Measurement‐based care (MBC) is a structured approach using standardized, repeated assessments to monitor treatment progress and guide clinical decision‐making. MBC improves outcomes for substance use treatment but can be time consuming due in part to lengthy assessment tools. Single‐item, patient‐reported outcome measures (
Thomas J. Reese   +13 more
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

open access: yesAllergy, Volume 81, Issue 9, Page 3039-3070, September 2026.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
Franziska Roth‐Walter   +20 more
wiley   +1 more source

Prevalence and Burden of Fatigue Across Disorders of Gut–Brain Interaction: Results From the Rome Foundation Global Epidemiology Study

open access: yesAlimentary Pharmacology &Therapeutics, Volume 64, Issue 5, Page 659-674, September 2026.
Fatigue is common and burdensome in disorders of gut‐brain interaction and increases with diagnostic overlap. In this global population‐based study, fatigue was associated with female sex, age, BMI, sleep disturbance, higher anxiety and depression scores, greater somatic symptom burden, lower psychological well‐being, antidepressant use, and greater ...
Fleur Veldman   +7 more
wiley   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan   +3 more
wiley   +1 more source

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