Results 121 to 130 of about 1,463,708 (228)

Molecular evidence of kappa opioid receptor (KOR) in rat heart.

, 2015
After rat hearts were harvested from the animals, total RNA was isolated and tissue specimen prepared for real-time PCR (A) and immunofluorecent staining (B) as described in Methods.
Hsiao-Ting Wang (16727), Hsin-Ju Tsai (306049), Jen-Hwey Chiu (526532), Meng-Ting Tsou (802843), Shiang-Suo Huang (534200)   +4 more
core   +1 more source

Enhanced humoral response in kappa-opioid receptor knockout mice

, 2003
Opiates are major analgesics and addictive drugs described also as immunomodulators. Here, we investigated the contribution of kappa-opioid receptor (KOR) activity in immunity in vivo by studying immune responses in KOR knockout mice.
Simonin, Frédéric, Kieffer, Brigitte, Gaveriaux-Ruff, Claire, Filliol, Dominique   +3 more
core   +1 more source

Differential time course of the effects of kappa-opioid agonist treatment on dynorphin A and on k-opioid receptor density

, 2004
The effects of kappa-opioid agonist treatment on kappa-opioid receptor density and on dynorphin A levels in the rat brain were studied. Rats were treated with the selective kappa-opioid agonist U-69593 or vehicle for 5 d.
ROMUALDI P., CANDELETTI, SANZIO, IZENWASSER S., DADDARIO C., DI BENEDETTO M., CANDELETTI S., ROMUALDI, PATRIZIA, D'ADDARIO, Claudio, DI BENEDETTO, MANUELA, Izenwasser, Sari   +9 more
core   +1 more source

Brief Prenatal Ethanol Exposure Alters Behavioral Sensitivity to the Kappa Opioid Receptor Agonist (U62,066E) and Antagonist (Nor-BNI) and Reduces Kappa Opioid Receptor Expression [PDF]

, 2014
Approximately 10 to 15% of women consume alcohol (ethanol [EtOH]) during pregnancy in the United States. Even low amounts of EtOH consumption during pregnancy can elicit long-term consequences.
Landin, Justine, Varlinskaya, Elena, Werner, David F., Carter, Jenna M., Nizhnikov, Michael E., Spear, Norman E., Pautassi, Ricardo M., Bordner, Kelly   +7 more
core  

RGS6 regulates Kappa opioid receptor-mediated antinociceptive behaviors. [PDF]

Neuropharmacology
Blount AP, Sutton LP.
europepmc   +1 more source

Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor. [PDF]

Nat Commun, 2023
Muratspahić E, Deibler K, Han J, Tomašević N, Jadhav KB, Olivé-Marti AL, Hochrainer N, Hellinger R, Koehbach J, Fay JF, Rahman MH, Hegazy L, Craven TW, Varga BR, Bhardwaj G, Appourchaux K, Majumdar S, Muttenthaler M, Hosseinzadeh P, Craik DJ, Spetea M, Che T, Baker D, Gruber CW.   +23 more
europepmc   +1 more source

Structural characterization of kappa-opioid receptor dimer in complex with two G proteins. [PDF]

Nat Commun
Zhao Y, Xu C, Wang Y, Shan H, Wang J, Liu Y, Luo X, Li J, Li M, Liu Y, Wu K, Roth BL, Huang XP, Xu HE, Liu J, Zhuang Y.   +15 more
europepmc   +1 more source

Nalmefene Hydrochloride: Potential Implications for Treating Alcohol and Opioid Use Disorder

Substance Abuse and Rehabilitation
MeShell Green,1 Charles A Veltri,1 Oliver Grundmann1,2 1College of Pharmacy, Department of Pharmaceutical Sciences, Midwestern University, Glendale, AZ, USA; 2College of Pharmacy, Department of Medicinal Chemistry, University of Florida, Gainesville, FL,
Green M, Veltri CA, Grundmann O
doaj  

Kappa opioid receptor availability correlates with depressive symptom burden in chronic migraine: a preliminary investigation. [PDF]

J Headache Pain
Kim DJ, Saberi M, Kaur T, Shao X, Koeppe RA, Scott PJH, Porreca F, DaSilva AF.   +7 more
europepmc   +1 more source

A kappa opioid receptor agonist, difelikefalin, improves acute kidney injury in experimental sepsis models. [PDF]

PLoS One
Sawanobori Y, Nakano D, Kitamura H, Kitada K, Asaga T, Suzuki N, Yamamoto M, Ogino Y, Shirakami G, Nishiyama A.   +9 more
europepmc   +1 more source