Results 101 to 110 of about 71,106 (270)

Effects of Kappa Opioid Receptor Agonists on Fentanyl vs. Food Choice in Male and Female Rats: Contingent vs. Non-Contingent Administration [PDF]

, 2020
E. Andrew Townsend
openalex   +1 more source

Unlocking the Antioxidant, Enzyme Inhibitory and Acaricidal Potential of Azadirachta indica Phytoconstituents Using In Vitro and In Silico Approaches

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
The study evaluated the acaricidal potential of bioactive components of Azadirachta indica against scabies mortality using both in vitro and in silico methodologies. Sarcoptes scabiei were stimulated with Azadirachta indica at four concentrations (25–100 mg/mL) at different intervals.
Tehreem Fatima, Mazhar Abbas, Kinza Zafar, Maha Gul Zafar, Waqas Haider, Muhammad Haseeb Zafar, Muhammad Riaz, Munawar Iqbal, Andrew G. Mtewa   +8 more
wiley   +1 more source

Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile

Frontiers in Psychiatry, 2018
A series of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydronoroxymorphinone compounds has been synthesized and evaluated for affinity and efficacy for mu (MOP), kappa (KOP), and delta (DOP) opioid receptors and nociceptin/orphanin FQ peptide (NOP ...
Vinod Kumar, Willma E. Polgar, Gerta Cami-Kobeci, Mark P. Thomas, Taline V. Khroyan, Lawrence Toll, Stephen M. Husbands   +6 more
doaj   +1 more source

Possible Involvement of Hallucinogenic Effects in the Aversive Effects Induced by Kappa‐Opioid and 5‐HT2A/2C Receptor Agonists in Mice

Neuropsychopharmacology Reports, Volume 45, Issue 4, December 2025.
This study developed a simple way to test new psychoactive substances (NPS) in mice. Two drugs, U50,488H and DOI caused aversive and abnormal behaviors in mice, likely linked to their hallucinogenic properties. These results suggest such behavioral tests could help quickly identify and regulate harmful psychoactive drugs. ABSTRACT Aim The regulation of
Hideaki Kato, Yoshimi Ichimaru, Masaaki Kurihara, Koushirou Sogawa, Masahiko Funada, Tsutomu Suzuki   +5 more
wiley   +1 more source

Nalfurafine is Aversive at Antinociceptive Doses in Mice

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
ABSTRACT Nalfurafine is the only clinically approved kappa opioid receptor (KOPr) agonist that can cross the blood–brain barrier and exert CNS effects. Because its clinical use is not associated with dysphoria, it is widely believed to have an atypical pharmacological profile.
E. J. Kuijer, L. H. Marinelli, S. J. Bailey, D. J. Heal, S. Smith, S. Wonnacott, C. P. Bailey   +6 more
wiley   +1 more source

Dynorphin-dependent reduction of excitability and attenuation of inhibitory afferents of NPS neurons in the pericoerulear region of mice

Frontiers in Cellular Neuroscience, 2016
The Neuropeptide S system, consisting of the 20-amino acid peptide neuropeptide S (NPS) and its G-protein coupled receptor (NPSR), modulates arousal, wakefulness, anxiety, and fear-extinction in mice.
Kay eJuengling, Peter eBlaesse, Lena eGoedecke, Hans-Christian ePape   +3 more
doaj   +1 more source

Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor

Cell Death and Disease, 2014
Methamphetamine (METH) is a psychostimulant with high abuse potential and severe neurotoxicity. Recent studies in animal models have indicated that METH can impair the blood–brain barrier (BBB), suggesting that some of the neurotoxic effects resulting ...
Jing Ma, Jing Wan, Jingjing Meng, Santanu Banerjee, S. Ramakrishnan, Sabita Roy   +5 more
semanticscholar   +1 more source

The use of low‐dose dexmedetomidine constant rate infusion to stabilise blood glucose in a domestic ferret (Mustela putorius furo) with insulinoma undergoing sevoflurane anaesthesia

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract A 5.5‐year‐old, male domestic ferret (Mustela putorius furo) diagnosed with insulinoma was presented for a dental procedure under general anaesthesia. In insulinoma patients, it is essential to avoid hypoglycaemia. In other species, constant rate infusion of dexmedetomidine has been reported to sustain adequate blood glucose by inhibiting ...
Anika R. Schiele, Patricia E. Kunze, Manuela L. Wieser, Annette P. N. Kutter   +3 more
wiley   +1 more source

A Review of Exercise Interventions for Rehabilitation in Drug‐Dependent Individuals

Addiction Biology, Volume 30, Issue 12, December 2025.
The analysis of 39 core studies indicates that diverse exercise interventions have varying positive effects across different dimensions for various addiction populations. Exercise can exert beneficial impacts on the neurobiological mechanisms, as well as physiological and psychological aspects, of individuals with drug addiction.
Qinghua He, Li Zhu, Zhaosong Wang, Hao Wang, Yiyi Jiang, Xin Wang, Fuxuan Luo, Chaoyi Zhu, Changlong Zhan   +8 more
wiley   +1 more source

Cannabinoid and Kappa Opioid Receptors Reduce Potassium K Current via Activation of G_sProteins in Cultured Hippocampal Neurons [PDF]

, 2000
Robert E. Hampson, Jian Mu, Sam A. Deadwyler   +2 more
openalex   +1 more source