Results 121 to 130 of about 71,106 (270)

Kappa Opioid Receptors in Mesolimbic Terminals Mediate Escalation of Cocaine Consumption [PDF]

, 2023
Lydia Gordon-Fennell, Ryan D. Farero, Lauren M. Burgeno, Nancy L. Murray, Anupam Abraham, Marta E. Soden, Garret D. Stuber, Charles Chavkin, Larry S. Zweifel, Paul E. M. Phillips   +9 more
openalex   +1 more source

Mapping Kappa Opioid Receptor Binding in Titi Monkeys with [C]GR103545 PET

Molecular Imaging
Purpose The kappa opioid receptor (KOR) plays a pivotal role in stress- and anxiety-related behaviors, with growing evidence linking it to stress induced by social isolation and separation.
Alita Jesal D Almeida BEng, Brad A. Hobson PhD, Logan E. Savidge PhD, Claudia Manca BS, John P. Paulus BS, Karen L. Bales PhD, Abhijit J. Chaudhari PhD   +6 more
doaj   +1 more source

CJ-15,208, a Novel Kappa Opioid Receptor Antagonist from a Fungus, Ctenomyces serratus ATCC15502.

, 2002
Toshiyuki Saito, Hideo Hirai, Yoon-Jeong Kim, Yasuhiro Kojima, YASUE MATSUNAGA, Hiroyuki Nishida, TATSUO SAKAKIBARA, Osamu Suga, Tetsujo Sujaku, Nakao Kojima   +9 more
openalex   +2 more sources

The kappa-opioid receptor system : a role in ethanol withdrawal severity?

, 2004
Amy S. Beadles-Bohling
openalex   +1 more source

Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models

Nature Communications
Ibogaine and its main metabolite noribogaine provide important molecular prototypes for markedly different treatment of substance use disorders and co-morbid mental health illnesses.
Václav Havel, Andrew C. Kruegel, Benjamin Bechand, Scot McIntosh, Leia Stallings, Alana Hodges, Madalee G. Wulf, Mel Nelson, Amanda Hunkele, Michael Ansonoff, John E. Pintar, Christopher Hwu, Rohini S. Ople, Najah Abi-Gerges, Saheem A. Zaidi, Vsevolod Katritch, Mu Yang, Jonathan A. Javitch, Susruta Majumdar, Scott E. Hemby, Dalibor Sames   +20 more
doaj   +1 more source

Construction and characterization of a kappa opioid receptor devoid of all free cysteines [PDF]

, 2004
David E. Ott, Renato Frischknecht, Andreas Plückthun   +2 more
openalex   +1 more source

kappa-opioid receptor agonists modulate excitatory transmission in substantia gelatinosa neurons of the rat spinal cord [PDF]

, 1995
Mirjana Randić, Gong Cheng, Ljiljana D. Kojic   +2 more
openalex   +1 more source

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

Cell, 2018
T. Che, S. Majumdar, S. Zaidi, P. Ondachi, J. McCorvy, Sheng Wang, P. Mosier, R. Uprety, Eyal Vardy, B. Krumm, G. Han, Ming-Yue Lee, Ming-Yue Lee, Ming-Yue Lee, E. Pardon, J. Steyaert, Xi Ping Huang, Ryan T. Strachan, A. Tribo, G. Pasternak, F. Carroll, R. Stevens, V. Cherezov, V. Katritch, Daniel Wacker, B. Roth   +25 more
semanticscholar   +1 more source

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

Science Signaling, 2016
Tarsis F. Brust, J. Morgenweck, Susy Kim, J. Rose, Jason L. Locke, Cullen L. Schmid, Lei Zhou, Edward L Stahl, M. Cameron, Sarah M. Scarry, J. Aubé, S. Jones, T. J. Martin, L. Bohn   +13 more
semanticscholar   +1 more source

Novel dual kappa/mu opioid ligands based on a tetrahydroisoquinoline-valine hybrid nucleus

Scientific Reports
Opioid addiction constitutes a significant global health challenge. Kappa opioid receptor (KOP) modulators have demonstrated efficacy in treating resistant drug abuse cases.
Ahmad Abdelwaly, Hesham Safwan, Shamba Chatterjee, Mohamed Elsayed, Khaled M. Darwish, Amar Chittiboyina, Mohamed A. Helal   +6 more
doaj   +1 more source