Results 81 to 90 of about 71,106 (270)

Effects of Selective and Mixed-Action Kappa and Delta Opioid Receptor Agonists on Pain-Related Behavioral Depression in Mice

Molecules
We recently developed a series of nalfurafine analogs (TK10, TK33, and TK35) that may serve as non-addictive candidate analgesics. These compounds are mixed-action agonists at the kappa and delta opioid receptors (KOR and DOR, respectively) and produce ...
S. Stevens Negus, Celsey M. St. Onge, Young K. Lee, Mengchu Li, Kenner C. Rice, Yan Zhang   +5 more
doaj   +1 more source

Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons

Journal of Neuroscience, 2015
The endogenous dynorphin-κ opioid receptor (KOR) system encodes the dysphoric component of the stress response and controls the risk of depression-like and addiction behaviors; however, the molecular and neural circuit mechanisms are not understood.
Jonathan M. Ehrich, Daniel I. Messinger, Cerise R Knakal, J. Kuhar, Selena S. Schattauer, M. Bruchas, L. Zweifel, B. Kieffer, P. Phillips, C. Chavkin   +9 more
semanticscholar   +1 more source

Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management

Journal of Internal Medicine, EarlyView.
Abstract Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composition. Type I, a rare form, involves monoclonal IgM or IgG and is linked to lymphoproliferative disorders.
Anna Linda Zignego, Laura Gragnani, Marcella Visentini, Riccardo Bomben, Luca Arcaini, Clodoveo Ferri, Valter Gattei, Cesare Mazzaro   +7 more
wiley   +1 more source

The distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence in mice

British Journal of Pharmacy, 2018
A Combination of 0.3mg/kg buprenorphine and 1.0 mg/kg naltrexone treatment shows a promising result due to its ability to attenuate reinstatement (relapse) in morphine/methamphetamine (polydrug)-dependent mice in a conditioned place preference (CPP ...
Irna Elina Ridzwan, Maryam Saadah Suhaimi, Nur Syafinaz Wasli, Abdul Razak Kasmuri, Marwan Saad Azzubaidi, Ridzwan Hashim, Qamar Uddin Ahmed, Long Chiau Ming, Nornisah Mohamed, Syed Mohd Syhami   +9 more
doaj   +1 more source

Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula

Neurobiology of Stress, 2020
The lateral habenula (LHb) is an epithalamic brain region associated with value-based decision making and stress evasion through its modulation of dopamine (DA)-mediated reward circuitry.
Sarah C. Simmons, Ryan D. Shepard, Shawn Gouty, Ludovic D. Langlois, William J. Flerlage, Brian M. Cox, Fereshteh S. Nugent   +6 more
doaj   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Evaluation of buprenorphine as optimisation of postoperative analgesia in feral cats undergoing ovariohysterectomy under field conditions

Journal of Small Animal Practice, EarlyView.
Objectives The objective of this prospective, randomised, blinded, observational clinical study was to investigate the effect of subcutaneously administered buprenorphine on postoperative pain in female feral cats undergoing ovariohysterectomy as part of a trap‐neuter‐return programme.
V. Heitzmann, A. Diggelmann, E. Goldinger, A. Schiele   +3 more
wiley   +1 more source

Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction

Frontiers in Neuroscience, 2015
Behavioral, biological, and social sequelae that lead to drug addiction differ between men and women. Our efforts to understand addiction on a mechanistic level must include studies in both males and females.
E. Chartoff, M. Mavrikaki
semanticscholar   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

How to treat addicted patient with concomitant psychiatric diagnosis?

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2018
Alcohol use disorders often co-occur with affective disorders, anxiety disorders and schizophrenia. The presence of dual diagnosis worsens the prognosis in patients.
A. Y. Egorov, F. Sh. Shagiahmetov
doaj