Results 181 to 190 of about 5,815 (206)

Cloning and characterization of Plasmodium falciparum homologs of nuclear import factors, karyopherin α and karyopherin β

Molecular and Biochemical Parasitology, 2003
Asif Mohmmed, Shivendra Kishore, Pawan Malhotra   +2 more
exaly   +3 more sources

Karyopherins and nuclear import

Current Opinion in Structural Biology, 2001
Proteins of the karyopherin alpha and karyopherin beta families play a central role in nucleocytoplasmic transport. Recently, crystal structures of karyopherin alpha and its complexes with nuclear localization signal peptides, a karyopherin beta2-Ran complex and complexes of full-length and fragments of karyopherin beta1 with import substrates, Ran and
Y M, Chook, G, Blobel
openaire   +2 more sources

Karyopherins and kissing cousins

Trends in Cell Biology, 1998
In eukaryotic cells, a regulated flux of molecules between the cytoplasm and the nucleus maintains two very different environments while allowing the controlled exchange of macromolecules necessary for their individual functions. Molecules entering or leaving the nucleus use nuclear localization signals or nuclear export signals to pass through ...
R W, Wozniak, M P, Rout, J D, Aitchison
openaire   +2 more sources

Karyopherin flexibility in nucleocytoplasmic transport

Current Opinion in Structural Biology, 2006
Recent structural work on nuclear transport factors of the importin-beta superfamily of karyopherins has shown that these proteins are superhelices of HEAT repeats that are able to assume different conformations in different functional states. The inherent flexibility of these helicoids facilitates the accommodation of different binding partners by an ...
Elena, Conti, Christoph W, Müller, Murray, Stewart   +2 more
openaire   +2 more sources

Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α

Cell, 1998
Selective nuclear import is mediated by nuclear localization signals (NLSs) and cognate transport factors known as karyopherins or importins. Karyopherin α recognizes “classical” monopartite and bipartite NLSs. We report the crystal structure of a 50 kDa
Elena Conti, G Blobel, John Kuriyan
exaly   +2 more sources

Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas

Journal of Neuro-Oncology, 2012
The karyopherin (KPNA) protein family is involved in nucleocytoplasmic trafficking. Increased KPNA levels have been found to predict poor prognosis for a variety of solid tumors, including breast, ovarian, cervical, and prostate cancer, and melanoma. The purpose of this study was to evaluate karyopherin a2 as novel biomarker for astrocytic gliomas of ...
Albert J Becker
exaly   +3 more sources

Identification of karyopherin-alpha 2 as an Oct4 associated protein

Journal of Genetics and Genomics, 2008
The POU domain transcription factor Oct4 is a master regulator in maintaining self-renewal and pluripotency of embryonic stem (ES) cells. To further explore the functional network of Oct4, the yeast two-hybrid system was used to search for Oct4 interacting proteins.
Xiangqun, Li, Lei, Sun, Ying, Jin
openaire   +2 more sources

A photoregulated ligand for the nuclear import receptor karyopherin α

Bioorganic & Medicinal Chemistry, 2001
The ability to orchestrate the transport of proteins between nucleus and cytoplasm provides cells with a powerful regulatory mechanism. Selective translocation between these compartments is often used to propagate cellular signals, and it is an intimate part of the processes that control cell division, viral replication, and other cellular events ...
S B, Park, R F, Standaert
openaire   +2 more sources

Karyopherin-mediated import of integral inner nuclear membrane proteins

Nature, 2006
Targeting of newly synthesized integral membrane proteins to the appropriate cellular compartment is specified by discrete sequence elements, many of which have been well characterized. An understanding of the signals required to direct integral membrane proteins to the inner nuclear membrane (INM) remains a notable exception.
Megan C, King, C Patrick, Lusk, Günter, Blobel   +2 more
openaire   +2 more sources

The vaccinia virus N2 protein associates with karyopherins α2 and α4 and reduces the turnover rate of karyopherin α2

2014
Due to their large genomes, poxviruses encode a number of enzymes, including a DNA polymerase and a DNA-dependent RNA polymerase, and therefore require few host gene factors for their replication. Several studies have shown several host nuclear factors are in fact recruited to viral sites of replication.
openaire   +1 more source