Results 181 to 190 of about 9,891 (213)

Multi-omics profiling highlights karyopherin subunit alpha 2 as a promising biomarker for prognosis and immunotherapy respond in pediatric and adult adrenocortical carcinoma. [PDF]

Ann Med
Chen Y, Fang S, Zhong C, Mo S, Shi Y, Ling X, Liu F, Zhong W, Deng J, Dong Z, Chen J, Lu J.   +11 more
europepmc   +1 more source

Foot-and-mouth disease virus VP4 interferes with host interferon response by targeting the nuclear translocation of interferon regulatory factor 3 (IRF3). [PDF]

Vet Res
Subasinghe A, Nethmini NAN, Weerawardhana A, Gamage N, Haluwana DK, Lee JS.   +5 more
europepmc   +1 more source

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Karyopherin-mediated nucleocytoplasmic transport

Nature Reviews Molecular Cell Biology, 2022
Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of the macromolecular traffic across the nuclear pores is mediated by the Karyopherin-β (or Kap) family of nuclear transport receptors.
Casey E Wing, Ho Yee Joyce Fung, Yuh Min Chook   +2 more
exaly   +3 more sources

Karyopherin abnormalities in neurodegenerative proteinopathies [PDF]

Brain, 2021
Abstract Neurodegenerative proteinopathies are characterized by progressive cell loss that is preceded by the mislocalization and aberrant accumulation of proteins prone to aggregation. Despite their different physiological functions, disease-related proteins like tau, α-synuclein, TAR DNA binding protein-43, fused in sarcoma and mutant ...
Terouz Pasha, Anna Zatorska, Daulet Sharipov   +2 more
exaly   +4 more sources

Nuclear import by karyopherin-βs: Recognition and inhibition

Biochimica Et Biophysica Acta - Molecular Cell Research, 2011
Proteins in the karyopherin-β family mediate the majority of macromolecular transport between the nucleus and the cytoplasm. Eleven of the 19 known human karyopherin-βs and 10 of the 14S. cerevisiae karyopherin-βs mediate nuclear import through recognition of nuclear localization signals or NLSs in their cargos.
Yuh Min Chook
exaly   +3 more sources

The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation [PDF]

International Journal of Cancer, 2009
AbstractThe Karyopherin proteins are involved in nucleo‐cytoplasmic trafficking and are critical for protein and RNA subcellular localization. Recent studies suggest they are important in nuclear envelope component assembly, mitosis and replication. Since these are all critical cellular functions, alterations in the expression of the Karyopherins may ...
Pauline J Van Der Watt, Dhirendra Govender, Virna D Leaner   +2 more
exaly   +3 more sources

Karyopherins and nuclear import

Current Opinion in Structural Biology, 2001
Proteins of the karyopherin alpha and karyopherin beta families play a central role in nucleocytoplasmic transport. Recently, crystal structures of karyopherin alpha and its complexes with nuclear localization signal peptides, a karyopherin beta2-Ran complex and complexes of full-length and fragments of karyopherin beta1 with import substrates, Ran and
Y M, Chook, G, Blobel
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Karyopherins and kissing cousins

Trends in Cell Biology, 1998
In eukaryotic cells, a regulated flux of molecules between the cytoplasm and the nucleus maintains two very different environments while allowing the controlled exchange of macromolecules necessary for their individual functions. Molecules entering or leaving the nucleus use nuclear localization signals or nuclear export signals to pass through ...
R W, Wozniak, M P, Rout, J D, Aitchison
openaire   +2 more sources

Karyopherin-mediated import of integral inner nuclear membrane proteins

Nature, 2006
Targeting of newly synthesized integral membrane proteins to the appropriate cellular compartment is specified by discrete sequence elements, many of which have been well characterized. An understanding of the signals required to direct integral membrane proteins to the inner nuclear membrane (INM) remains a notable exception.
Megan C King, C Patrick Lusk, Günter Blobel   +2 more
exaly   +3 more sources

Recognition of nuclear targeting signals by Karyopherin-β proteins [PDF]

Current Opinion in Structural Biology, 2010
The Karyopherin-β family of nuclear transport factors mediates the majority of nucleocytoplasmic transport. Although each of the 19 Karyopherin-βs transports unique sets of cargos, only three classes of nuclear localization and export signals, or NLSs and NESs, have been characterized. The short basic classical-NLS was first discovered in the 1980s and
Darui Xu, Yuh Min Chook
exaly   +3 more sources