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Karyopherin flexibility in nucleocytoplasmic transport
Current Opinion in Structural Biology, 2006Recent structural work on nuclear transport factors of the importin-beta superfamily of karyopherins has shown that these proteins are superhelices of HEAT repeats that are able to assume different conformations in different functional states. The inherent flexibility of these helicoids facilitates the accommodation of different binding partners by an ...
Elena, Conti +2 more
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The dynamics of karyopherin-mediated nuclear transport
Biochemistry and Cell Biology, 2001The regulated exchange of proteins and nucleic acids between the nucleus and cytoplasm demands a complex interplay between nuclear pore complexes (NPCs), which provide conduits in the nuclear envelope, and mobile transport receptors (or karyopherins, also known as importins/exportins) that bind and mediate the translocation of cargoes through the NPCs.
M, Marelli +3 more
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The binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequence. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1996 By using proteolysis, recombinant mutant proteins, or synthetic peptides and by testing these reagents in liquid phase binding or nuclear import assays, we have mapped binding regions of karyopherin alpha. We found that the C-terminal region of karyopherin alpha recognizes the nuclear localization sequence (NLS), whereas its N-terminal region binds ...
J, Moroianu, G, Blobel, A, Radu
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Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas
Journal of Neuro-Oncology, 2012The karyopherin (KPNA) protein family is involved in nucleocytoplasmic trafficking. Increased KPNA levels have been found to predict poor prognosis for a variety of solid tumors, including breast, ovarian, cervical, and prostate cancer, and melanoma. The purpose of this study was to evaluate karyopherin a2 as novel biomarker for astrocytic gliomas of ...
K, Gousias +3 more
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Karyopherins: from nuclear-transport mediators to nuclear-function regulators
Trends in Cell Biology, 2004The karyopherin beta (or importin beta) family comprises soluble transport factors that mediate the movement of proteins and RNAs between the nucleus and cytoplasm. Recent studies have extended the role of karyopherins to regulating assembly of the nuclear pore complex (NPC), assembly of the nuclear envelope, mitosis and replication.
Nima, Mosammaparast, Lucy F, Pemberton
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Identification of karyopherin-alpha 2 as an Oct4 associated protein
Journal of Genetics and Genomics, 2008The POU domain transcription factor Oct4 is a master regulator in maintaining self-renewal and pluripotency of embryonic stem (ES) cells. To further explore the functional network of Oct4, the yeast two-hybrid system was used to search for Oct4 interacting proteins.
Xiangqun, Li, Lei, Sun, Ying, Jin
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2014
Due to their large genomes, poxviruses encode a number of enzymes, including a DNA polymerase and a DNA-dependent RNA polymerase, and therefore require few host gene factors for their replication. Several studies have shown several host nuclear factors are in fact recruited to viral sites of replication.
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Due to their large genomes, poxviruses encode a number of enzymes, including a DNA polymerase and a DNA-dependent RNA polymerase, and therefore require few host gene factors for their replication. Several studies have shown several host nuclear factors are in fact recruited to viral sites of replication.
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Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp
Nature, 1999Yuh Min Chook, Günter Blobel
exaly