Results 231 to 240 of about 6,766 (259)

The Potential of Nuclear Pore Complexes in Cancer Therapy. [PDF]

Molecules
Zaitsava H, Gachowska M, Bartoszewska E, Kmiecik A, Kulbacka J.   +4 more
europepmc   +1 more source

Autophagy modulates glioblastoma cell sensitivity to Selinexor-mediated XPO1 inhibition. [PDF]

Neuro Oncol
Tang Y, Sprinzen L, Terada Y, Kiang KM, Li C, Zeng Y, Liu F, Zhou H, Liang X, Zhang J, Pieper RO, Chen B, Zhang L.   +12 more
europepmc   +1 more source

Combined XPO1 Inhibition and Parthenolide Treatment Can Be Efficacious in Treating Triple-Negative Breast Cancer. [PDF]

Int J Mol Sci
Paulson AL, Elmorsi RM, Lee AM, Huang RS.   +3 more
europepmc   +1 more source

Importin α2 participates in RNA interference against bamboo mosaic virus accumulation in Nicotiana benthamiana via NbAGO10a-mediated small RNA clearance. [PDF]

Mol Plant Pathol
Wang JD, Hsu YH, Lee YS, Lin NS.
europepmc   +1 more source

miR-7-5p and Importin-7 Regulate the p53 Dynamics and Stability in Malignant and Benign Thyroid Cells. [PDF]

Int J Mol Sci
Al-Abdallah A, Jahanbani I, Al-Shammari B.   +2 more
europepmc   +1 more source

Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase. [PDF]

Nat Commun
Baytshtok V, DiMattia MA, Lima CD.
europepmc   +1 more source

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Karyopherins and nuclear import.

Current Opinion in Structural Biology, 2001
Proteins of the karyopherin alpha and karyopherin beta families play a central role in nucleocytoplasmic transport. Recently, crystal structures of karyopherin alpha and its complexes with nuclear localization signal peptides, a karyopherin beta2-Ran complex and complexes of full-length and fragments of karyopherin beta1 with import substrates, Ran and
Y. Chook, G. Blobel
semanticscholar   +3 more sources

Karyopherins and kissing cousins.

Trends in Cell Biology, 1998
In eukaryotic cells, a regulated flux of molecules between the cytoplasm and the nucleus maintains two very different environments while allowing the controlled exchange of macromolecules necessary for their individual functions. Molecules entering or leaving the nucleus use nuclear localization signals or nuclear export signals to pass through ...
R. Wozniak, M. Rout, J. Aitchison
semanticscholar   +3 more sources

Karyopherins: from nuclear-transport mediators to nuclear-function regulators.

Trends in Cell Biology, 2004
The karyopherin beta (or importin beta) family comprises soluble transport factors that mediate the movement of proteins and RNAs between the nucleus and cytoplasm. Recent studies have extended the role of karyopherins to regulating assembly of the nuclear pore complex (NPC), assembly of the nuclear envelope, mitosis and replication.
N. Mosammaparast, L. Pemberton
semanticscholar   +3 more sources

Karyopherin-mediated nucleocytoplasmic transport

Nature Reviews Molecular Cell Biology, 2022
Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of the macromolecular traffic across the nuclear pores is mediated by the Karyopherin-β (or Kap) family of nuclear transport receptors.
Casey E. Wing, Ho Yee Joyce Fung, Yuh Min Chook   +2 more
openaire   +2 more sources