Results 11 to 20 of about 58,318 (161)

Transcriptome-wide RNA m6A methylation profiles in an endemic osteoarthropathy, Kashin-Beck disease. [PDF]

J Cell Mol Med
Kashin‐Beck disease (KBD) is a chronic degenerative, disabling disease of the bones and joints and its exact aetiology and pathogenesis remain uncertain. This study is to investigate the role of m6A modification in the pathogenesis of KBD.
Zhang Q, Yang X, Deng X, Niu H, Zhao Y, Wen J, Wang S, Liu H, Guo X, Wu C.   +9 more
europepmc   +3 more sources

Prevalence and Risk Factors of Depression in Patients With Endemic Osteoarthritis Kashin-Beck Disease. [PDF]

Depress Anxiety
Background: Kashin–Beck disease (KBD) is an endemic osteoarthropathy, which occurs in children aged 3–12, with similarity to osteoarthritis (OA). Previous studies have shown significant depression symptoms in OA patients, yet no comparable research has ...
Liu Y, Wen Y, Yang Z, Zhou R, Hui J, Li C, Xu G, Liu C, Liu H, Cheng B, Jia Y, Guo X, Zhang F.   +12 more
europepmc   +3 more sources

A Comparison of Transfer Learning Metaphyseal Sign Diagnostic Models for Kashin-Beck Disease Based on X-rays of Children's Hands. [PDF]

Cureus
Background Kashin-Beck disease (KBD), prevalent in certain regions of the world, primarily affects children and is characterized by joint deformities. Timely screening and accurate diagnosis, heavily reliant on metaphyseal signs in X-rays, are crucial ...
Li G, Zhang H, Chen P, Song Y, Zhang Y, Li C.   +5 more
europepmc   +2 more sources

Untargeted Metabolomics Approach Correlated Enniatin B Mycotoxin Presence in Cereals with Kashin–Beck Disease Endemic Regions of China [PDF]

Toxins, 2023
Kashin–Beck disease (KBD) is a multifactorial endemic disease that only occurs in specific Asian areas. Mycotoxin contamination, especially from the Fusarium spp., has been considered as one of the environmental risk factors that could provoke ...
Danlei Sun, Camille Chasseur, Françoise Mathieu, Jessica Lechanteur, Pierre Van Antwerpen, Joanne Rasschaert, Véronique Fontaine, Cédric Delporte   +7 more
doaj   +2 more sources

Detection of selenoprotein transcriptome in chondrocytes of patients with Kashin–Beck disease [PDF]

Frontiers in Cell and Developmental Biology, 2023
Background: Kashin–Beck disease (KBD) is a deformed osteochondral disease with a chronic progression that is restrictively distributed in eastern Siberia, North Korea, and some areas of China, and selenium deficiency has been identified as an important ...
Yi Gong, Yifan Wu, Yanli Liu, Sijie Chen, Feiyu Zhang, Feihong Chen, Chaowei Wang, Shujin Li, Minhan Hu, Ruitian Huang, Ke Xu, Xi Wang, Lei Yang, Yujie Ning, Cheng Li, Rong Zhou, Xiong Guo, Xiong Guo   +17 more
doaj   +2 more sources

Integrative Proteome and Transcriptome Analyses Reveal the Metabolic Disturbance of the Articular Cartilage in Kashin-Beck Disease, an Endemic Arthritis. [PDF]

Int J Mol Sci
The objective of this study was to elucidate the proteomic and transcriptomic alterations within the cartilage in Kashin–Beck disease (KBD) compared to a normal control. We conducted a comparison of the expression profiles of proteins, mRNAs, and lncRNAs
Han L, Cheng B, Xia J, Cheng S, Yang X, Zhang F.   +5 more
europepmc   +2 more sources

Cold weather and Kashin-Beck disease

Frigid Zone Medicine, 2023
Kashin-Beck disease (KBD) is an endemic osteoarthropathy. Its distribution region covers a long and narrow belt on the Pacific side and belongs to continental climate with short summer, long frost period, and large temperature differences between day and
Wang Kewei, Yu Jun, Sun Dianjun
doaj   +2 more sources

Combined Proximal Tibial Osteotomy for Adult Kashin–Beck Disease with Severe Varus Knee Osteoarthritis: Case Report and Literature Review [PDF]

Orthopaedic Surgery, 2022
Background Kashin–Beck disease (KBD) is an endemic, chronic osteoarthropathy that seriously affects joint function and can lead to severe knee deformity.
Yunfei Liu, Ruiyang Li, Yu Zhan, Xuetao Xie, Congfeng Luo   +4 more
doaj   +2 more sources

Comparison of the major cell populations among osteoarthritis, Kashin-Beck disease and healthy chondrocytes by single-cell RNA-seq analysis. [PDF]

Cell Death Dis, 2021
Chondrocytes are the key target cells of the cartilage degeneration that occurs in Kashin–Beck disease (KBD) and osteoarthritis (OA). However, the heterogeneity of articular cartilage cell types present in KBD and OA patients and healthy controls is ...
Wang X, Ning Y, Zhang P, Poulet B, Huang R, Gong Y, Hu M, Li C, Zhou R, Lammi MJ, Guo X.   +10 more
europepmc   +2 more sources

ATAC-seq reveals the roles of chromatin accessibility in the chondrocytes of Kashin–Beck disease compared with primary osteoarthritis [PDF]

Frontiers in Genetics, 2023
Objective: This study aimed to investigate the roles of accessible chromatin in understanding the different pathogeneses between Kashin–Beck disease (KBD) and primary osteoarthritis (OA).Methods: Articular cartilages of KBD and OA patients were collected,
Sen Wang, Yuanji Wang, Xingyu Li, Linlin Yuan, Xiong Guo, Mikko J. Lammi   +5 more
doaj   +2 more sources