Results 21 to 30 of about 58,318 (161)

Prevalence of T-2 Toxin in the Food and Beverages of Residents Living in a Kashin-Beck-Disease Area of Qamdo, Tibet. [PDF]

Nutrients
It has been strongly suggested that selenium deficiency and T-2 toxin contamination have a strong relationship with the occurrence and development of Kashin–Beck disease (KBD).
Jiang T, Yan J, Tan H, Pu Z, Wang O, Liu T, Chen Z, Gao J, Wang J, Lin J, Huo J, Huang J.   +11 more
europepmc   +2 more sources

Identifying discriminative features for diagnosis of Kashin-Beck disease among adolescents [PDF]

BMC Musculoskeletal Disorders, 2021
Introduction Diagnosing Kashin-Beck disease (KBD) involves damages to multiple joints and carries variable clinical symptoms, posing great challenge to the diagnosis of KBD for clinical practitioners.
Yanan Zhang, Xiaoli Wei, Chunxia Cao, Fangfang Yu, Wenrong Li, Guanghui Zhao, Haiyan Wei, Feng’e Zhang, Peilin Meng, Shiquan Sun, Mikko Juhani Lammi, Xiong Guo   +11 more
doaj   +2 more sources

Alterations in the gut microbiota and metabolite profiles of patients with Kashin-Beck disease, an endemic osteoarthritis in China. [PDF]

Cell Death Dis, 2021
Kashin-Beck disease (KBD) is a severe osteochondral disorder that may be driven by the interaction between genetic and environmental factors. We aimed to improve our understanding of the gut microbiota structure in KBD patients of different grades and ...
Wang X, Ning Y, Li C, Gong Y, Huang R, Hu M, Poulet B, Xu K, Zhao G, Zhou R, Lammi MJ, Guo X.   +11 more
europepmc   +2 more sources

Kashin-Beck Disease: A Risk Factor for Sarcopenia and Its Interaction with Selenium. [PDF]

Nutrients
Objectives: We aimed to explore the possible effects of Kashin–Beck disease (KBD) on the risk of sarcopenia and its possible interaction in the association between the risk of sarcopenia and element concentration.
Wu H, Chen Z, Wang O, Jiang T, Huang J, Wang J, Lin J.   +6 more
europepmc   +2 more sources

Identification of cell-specific epigenetic patterns associated with chondroitin sulfate treatment response in an endemic arthritis, Kashin-Beck disease [PDF]

Bone & Joint Research
Aims: To assess the alterations in cell-specific DNA methylation associated with chondroitin sulphate response using peripheral blood collected from Kashin-Beck disease (KBD) patients before initiation of chondroitin sulphate treatment.
Bolun Cheng, Cuiyan Wu, Wenming Wei, Hui Niu, Yan Wen, Cheng Li, Ping Chen, Hong Chang, Zhengjun Yang, Feng Zhang   +9 more
doaj   +2 more sources

A Metabolomics Study of Feces Revealed That a Disturbance of Selenium-Centered Metabolic Bioprocess Was Involved in Kashin-Beck Disease, an Osteoarthropathy Endemic to China. [PDF]

Nutrients, 2023
Background: Kashin–Beck disease (KBD) is a distinct osteoarthropathy in China with an unclear pathogenesis. This study aims to explore whether perturbations in the intestine metabolome could be linked to KBD individuals.
Wen Y, Wang B, Shi P, Chu X, Shi S, Yao Y, Zhang L, Zhang F.   +7 more
europepmc   +2 more sources

Patients with Kashin-Beck Disease Obtained Lower Functional Activities but Better Satisfaction Than Patients with Osteoarthritis After Total Knee Arthroplasty: A Retrospective Study [PDF]

Clinical Interventions in Aging, 2022
Liangzhi Zhang,1 Hui Li,1,2 Lulu Bai,1,2 NaiChun Ji1 1Department of Sports Health Research Center, Xi ‘an Medical University, Xi’an City, People’s Republic of China; 2Department of Knee Surgery, Hong Hui Hospital, Xi’an Jiaotong University, Xi’an City ...
Zhang L, Li H, Bai L, Ji N
doaj   +2 more sources

Health-related quality of life in patients with Kashin-Beck disease is lower than in those with osteoarthritis: a cross-sectional study. [PDF]

J Orthop Surg Res, 2023
Background Kashin–Beck disease (KBD) is an endemic deformable bone and joint disease, which affects the quality of life (QOL) of patients. We conducted a cross-sectional study of the QOL of KBD patients by a new KBD quality of life (KBDQOL) questionnaire.
Jin Z, Wu X, Sun Z, Chen M, Yang B, Dong X, Liu S, Chang Y, Xu C, Yi Z, Ling M.   +10 more
europepmc   +2 more sources

Whole-Transcriptome Sequencing of Knee Joint Cartilage from Kashin-Beck Disease and Osteoarthritis Patients. [PDF]

Int J Mol Sci
The aim of this study was to provide a comprehensive understanding of similarities and differences in mRNAs, lncRNAs, and circRNAs within cartilage for Kashin–Beck disease (KBD) compared to osteoarthritis (OA). We conducted a comparison of the expression
Han L, Cheng B, Wei W, Liu L, Cheng S, Liu H, Jia Y, Wen Y, Zhang F.   +8 more
europepmc   +2 more sources

Animal models of Kashin-Beck disease exposed to environmental risk factors: Methods and comparisons

Ecotoxicology and Environmental Safety, 2022
The main etiological mechanism for Kashin-Beck disease (KBD) is deep chondrocyte necrosis induced by environmental risk factors (ERFs). The scholars have conducted several epidemiological, cellular, and animal model studies on ERFs.
Fang-fang Yu, Juan Zuo, Lei Sun, Shui-yuan Yu, Xiao-li Lei, Jun-hua Zhu, Guo-yu Zhou, Xiong Guo, Yue Ba   +8 more
doaj   +2 more sources