Results 71 to 80 of about 58,318 (161)

LRP1 Mediates Endocytosis Activity and Is a Potential Therapeutic Target in Osteoarthritis

Orthopaedic Surgery, Volume 17, Issue 6, Page 1604-1619, June 2025.
(A) The risk factors associated with OA development. (B) Exosomes derived from TNF‐α stimulate upregulation of LRP1 levels in IPFP‐MSC‐derived exosomes, thereby exerting chondroprotective effects. (C) The regulation of endocytosis by LRP1, which impacts chondrocyte proliferation and apoptosis.
Yuangang Wu, Kaibo Sun, Mingyang Li, Yang Yang, Yuan Liu, Limin Wu, Yang Ding, Yi Zeng, Bin Shen   +8 more
wiley   +1 more source

Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritis

Frontiers in Genetics, 2022
Background and aims: Kashin-Beck disease (KBD) is a unique endemic osteochondropathy with unclear pathogenesis in China. T-2 toxin exposure has been identified as a significant risk factor of KBD.
Yujie Ning, Pan Zhang, Feiyu Zhang, Sijie Chen, Yanli Liu, Feihong Chen, Yifan Wu, Shujin Li, Chaowei Wang, Yi Gong, Minhan Hu, Ruitian Huang, Hongmou Zhao, Xiong Guo, Xiong Guo, Xi Wang, Lei Yang   +16 more
doaj   +1 more source

Geographical Patterns and Determinants of Selenium Deficiency in Tibet: A Cross‐Sectional Study Based on Urinary Selenium Analysis

Earth's Future, Volume 13, Issue 2, February 2025.
Abstract Selenium is an essential micronutrient, yet its deficiency poses severe health risks, including Kashin‐Beck disease, a debilitating disorder endemic to selenium‐deficient regions like Tibet. Despite the known risks, the extent and drivers of selenium deficiency in Tibetan populations remain poorly characterized.
Yi Yang, Ru Zhang, Yangzong Deji, You Li, Yonghua Li   +4 more
wiley   +1 more source

Kashin-Beck's disease

Kazan medical journal, 1927
Endemic arthritis or the so-called "Urovskaya disease" was first discovered by Dr. Kashin 75 years ago among residents of the Ura river valley (in Transbaikalia), hence the name "Urovskaya disease". The author calls this peculiar disease ache disease. With regard to etiology, Dr.
openaire   +1 more source

Iodine Intake Increases IP-10 Expression in the Serum and Thyroids of Rats with Experimental Autoimmune Thyroiditis

International Journal of Endocrinology, 2014
Here, we sought to establish an experimental autoimmune thyroiditis rat model induced by bovine thyroglobulin (bTg) injection and to investigate pathological changes and variations in serum interferon-γ-inducible protein of 10 kDa (IP-10) in thyroid ...
Si-lu Cui, Jun Yu, Liu Shoujun
doaj   +1 more source

Evaluation of Soil Samples Preparation Techniques for Detecting Selenium by Using Atomic Fluorescence Spectroscopy‐Based Detection

Journal of Analytical Methods in Chemistry, Volume 2025, Issue 1, 2025.
Selenium (Se) can cause poisoning in the human body, including dry, brittle, and easy‐to‐fall‐off hair, white spots and longitudinal lines of nails, skin damage, nervous system abnormalities, and even death. In order to optimize the experimental process for the sensitive detection of Se in samples by atomic fluorescence spectrometry (AFS), an excellent
Lin Zhu, Zheng-he Hu, Xiu-long Chen, Surat Hongsibsong, Tulika Banerjee   +4 more
wiley   +1 more source

UEG Week 2023 Poster Presentations

, 2023
United European Gastroenterology Journal, Volume 11, Issue S8, Page 535-1498, October 2023.
wiley   +1 more source

Clinical manifestations of Kashin-Beck disease in Nyemo Valley, Tibet [PDF]

International Orthopaedics, 1997
Clinical manifestations of Kashin-Beck disease have been studied in Central Tibet. Statistical analysis of physical signs allowed a definition of the clinical diagnosis and a scale for the functional severity for the disease to be drawn up. This classification is used for the assessment of patients who received palliative physical treatment. A group of
Mathieu, Françoise, Begaux, Françoise, Lan, Z Y, Suetens, C., Hinsenkamp, Maurice   +4 more
openaire   +2 more sources

Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study

Frontiers in Genetics, 2021
Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is a primary metabolite of T-2 toxin, was regarded as one of the environmental risk factors of KBD.
Yanan Zhang, Yanan Zhang, Huan Liu, Huan Liu, Xialu Lin, Xialu Lin, Feng’e Zhang, Feng’e Zhang, Peilin Meng, Peilin Meng, Sijia Tan, Sijia Tan, Mikko J. Lammi, Mikko J. Lammi, Xiong Guo, Xiong Guo   +15 more
doaj   +1 more source

An experimental animal model of Kashin-Beck disease. [PDF]

Annals of the Rheumatic Diseases, 1989
Twelve young macaque monkeys were fed with grain and water from areas actively endemic or non-endemic for Kashin-Beck disease. Both dietary grain and water from geographical areas endemic for Kashin-Beck disease induced a sequence of pathological changes in the growth plates and articular cartilage and biochemical changes in the serum and urine of ...
G Q, Zhang, J X, Liu
openaire   +2 more sources